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We aimed to determine the role of monocyte miR-27a in EVs on arterial Mas receptor expression, and its involvement in the pathogenesis of hypertension.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>THP-1 cells were transfected with miR-27a mimic and miR-27a inhibitor, and EVs were collected. Mas receptor expression and endothelial nitric oxide synthase (eNOS) phosphorylation were determined by immunoblotting. Sprague\u2013Dawley (SD) rats received EVs via tail-vein injection. Blood pressure (BP) was measured with the tail-cuff method. The vasodilatory response of mesenteric arteries was measured using a small vessel myograph.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>EVs from THP-1 cells increased rat BP by impairing Ang-(1\u20137)-mediated vasodilation in mesenteric arteries, which was further exaggerated by EVs from lipopolysaccharides-treated THP-1 cells. As the receptor and key signaling of Ang-(1\u20137), next experiments found that Mas receptor expression and eNOS phosphorylation were decreased in mesenteric arteries from EVs-treated SD rats. Screening studies found miR-27a in EVs may be involved in this process. Through transfection with miR-27a inhibitor or miR-27a mimic, we found that miR-27a downregulates Mas receptor expression in endothelial cells. Injection of EVs from miR-27a-transfected HEK-293 cells decreased Mas receptor and eNOS phosphorylation in mesenteric arteries, impaired Ang-(1\u20137)-mediated vasodilation and increased BP. Earlier effects were reversed using cells with downregulation of miR-27 in EVs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Monocyte miR-27a in EVs decreases Mas receptor expression and eNOS phosphorylation in endothelium, impairs Ang-(1\u20137)-mediated vasodilation, and causes hypertension. Understanding the contributions of EVs in the pathogenesis of hypertension may facilitate their use as a diagnostic biomarker.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpz112","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T11:13:20Z","timestamp":1562930000000},"page":"31-42","source":"Crossref","is-referenced-by-count":34,"title":["Secreted Monocyte miR-27a, via Mesenteric Arterial Mas Receptor-eNOS Pathway, Causes Hypertension"],"prefix":"10.1093","volume":"33","author":[{"given":"Xue","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Cardiology, Daping Hospital, The Third Military Medical University , Chongqing, P.R. China"},{"name":"Chongqing Institute of Cardiology and Chongqing Key Laboratory for Hypertension Research , Chongqing, P.R. 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China"},{"name":"Chongqing Institute of Cardiology and Chongqing Key Laboratory for Hypertension Research , Chongqing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong , Hong Kong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A","family":"Jose","sequence":"additional","affiliation":[{"name":"Division of Renal Disease and Hypertension, The George Washington University School of Medicine and Health Sciences , Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2954-758X","authenticated-orcid":false,"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University , Chongqing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Daping Hospital, The Third Military Medical University , Chongqing, P.R. China"},{"name":"Chongqing Institute of Cardiology and Chongqing Key Laboratory for Hypertension Research , Chongqing, P.R. 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