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Monocrotaline (MCT)-induced and hypoxia-induced pulmonary hypertension (PH) rodent models are the most widely used preclinical models, however, whether or not these preclinical models recapitulate metabolomic profiles of PAH patients remain unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In this study, a targeted metabolomics panel of 126 small molecule metabolites was conducted. We applied it to the plasma of the 2 preclinical rodent models of PH and 30 idiopathic pulmonary arterial hypertension (IPAH) patients as well as 30 healthy controls to comparatively assess the metabolomic profiles of PAH patients and rodent models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Significantly different metabolomics profiling and pathways were shown among the 2 classical rodent models and IPAH patients. Pathway analysis demonstrated that methionine metabolism and urea cycle metabolism were the most significant pathway involved in the pathogenesis of hypoxia-induced PH model and MCT-induced model, respectively, and both of them were also observed in the dysregulated pathways in IPAH patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>These 2 models may develop PAH through different metabolomic pathways and each of the 2 classical PH model resembles IPAH patients in certain aspects.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpz121","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T11:23:00Z","timestamp":1563967380000},"page":"1109-1117","source":"Crossref","is-referenced-by-count":20,"title":["Circulating Plasma Metabolomic Profiles Differentiate Rodent Models of Pulmonary Hypertension and Idiopathic Pulmonary Arterial Hypertension Patients"],"prefix":"10.1093","volume":"32","author":[{"given":"Jun-Han","family":"Zhao","sequence":"first","affiliation":[{"name":"Key Laboratory of Pulmonary Vascular Medicine and FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang-Yang","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pulmonary Vascular Medicine and FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-Shan","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pulmonary Vascular Medicine and FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China"},{"name":"Department of Biochemistry, Pharmaceutical College, Henan University , Kaifeng, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pulmonary Vascular Medicine and FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jue","family":"Ye","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pulmonary Vascular Medicine and FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Lan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiration, Beijing Shijitan Hospital, Capital Medical University , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Bin","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Pharmaceutical College, Henan University , Kaifeng, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Mei","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Pharmaceutical College, Henan University , Kaifeng, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Hui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield , Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2815-6993","authenticated-orcid":false,"given":"Zhi-Cheng","family":"Jing","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pulmonary Vascular Medicine and FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,27]]},"reference":[{"key":"2022101216053546000_CIT0001","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrcardio.2017.84","article-title":"Epidemiology and treatment of pulmonary arterial hypertension","volume":"14","author":"Lau","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"2022101216053546000_CIT0002","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 ESC\/ERS 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