{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:59:11Z","timestamp":1773338351337,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Carotid artery diameter responses to sympathetic stimulation, i.e., carotid artery reactivity (CAR), represent a novel test of vascular health and relates to cardiovascular disease (CVD)\/risk. This study aims to understand the relationship between the increase in blood pressure and carotid artery diameter response during the CAR-test in healthy, middle-aged men.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sample consisted of 40 normotensive men (aged 31\u201359 years) with no history of CVD of currently taking medication. Noninvasive ultrasound was used to measure carotid artery diameter during the cold pressor test (CPT), with CAR% being calculated as the relative change from baseline (%). Mean arterial pressure (MAP) was measured with beat-to-beat blood pressure recording.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>CAR% was 4.4 \u00b1 5.4%, peaking at 92 \u00b1 43 seconds. MAP increased from 88 \u00b1 9 mmHg to 110 \u00b1 15 mmHg, peaked at 112 \u00b1 38 seconds, which was significantly later than the diameter peak (P = 0.04). The correlation between resting MAP and CAR% was weak (r = 0.209 P = 0.197). Tertiles based on resting MAP or MAP-increase revealed no significant differences between groups in subject characteristics including age, body mass index, or CAR% (all P &amp;gt; 0.05). Subgroup analysis of individuals with carotid constriction (n = 6) vs. dilation (n = 34), revealed no significant difference in resting MAP or increase in MAP (P = 0.209 and 0.272, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our data suggest that the characteristic increase in MAP during the CPT does not mediate carotid artery vasomotion.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpz159","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T19:29:15Z","timestamp":1569007755000},"page":"146-153","source":"Crossref","is-referenced-by-count":9,"title":["Role of Blood Pressure in Mediating Carotid Artery Dilation in Response to Sympathetic Stimulation in Healthy, Middle-Aged Individuals"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7224-750X","authenticated-orcid":false,"given":"Arron","family":"Peace","sequence":"first","affiliation":[{"name":"Faculty of Education, Health and Community, Liverpool John Moores University , Liverpool, UK"},{"name":"Research Institute for Sport and Exercise Sciences, Liverpool John Moores University , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Pinna","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences, Liverpool John Moores University , Liverpool, UK"},{"name":"Department of Physiology, Radboudumc , Nijmegen, The Netherlands"},{"name":"Department of Medical Sciences and Public Health, Sports Physiology Lab, University of Cagliari , Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friso","family":"Timmen","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences, Liverpool John Moores University , Liverpool, UK"},{"name":"Department of Physiology, Radboudumc , Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillherme","family":"Speretta","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences, Liverpool John Moores University , Liverpool, UK"},{"name":"Department of Physiological Sciences, Biological Sciences Centre, Federal University of Santa Catarina (UFSC) , Florian\u00f3polis, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Jones","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences, Liverpool John Moores University , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn","family":"Lotto","sequence":"additional","affiliation":[{"name":"Faculty of Education, Health and Community, Liverpool John Moores University , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Jones","sequence":"additional","affiliation":[{"name":"Faculty of Education, Health and Community, Liverpool John Moores University , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"Thijssen","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences, Liverpool John Moores University , Liverpool, UK"},{"name":"Department of Physiology, Radboudumc , Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,9,27]]},"reference":[{"key":"2022100708274887200_CIT0001","unstructured":"World Health Organization. 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