{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:15:45Z","timestamp":1790727345155,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81500224 and 81670419"],"award-info":[{"award-number":["81500224 and 81670419"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M593044"],"award-info":[{"award-number":["2016M593044"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Transient receptor potential melastatin subtype 8 (TRPM8) is a cold-sensing cation channel, mainly localized in the sensory neurons, which can be activated by menthol, a compound with a naturally cold sensation in mint. However, the effect of TRPM8 activation in inflammation and cardiac remodeling after myocardial infarction (MI) is not well defined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>TRPM8 knockout (KO) mice (TRPM8\u2212\/\u2212) and their wild-type littermates, aged 8 weeks, were randomly divided into sham and MI groups and were fed with chow or chow plus menthol.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Dietary menthol significantly attenuated MI injury, evidenced by decreased survival rates and plasma cardiac troponion I levels, reduced infarct size and cardiomyocytes, declined collagen deposition, and rescued cardiac function and hemodynamics. However, these effects of menthol disappeared when mice were lacking TRPM8. Furthermore, feeding of menthol ameliorated elevated expression of inflammatory cytokines and chemokines, and aggravated inflammation infiltration in the MI mice but not in TRPM8\u2212\/\u2212 mice. In addition, menthol treatment increased the release of calcitonin gene-related peptide (CGRP), which were absent in TRPM8\u2212\/\u2212 mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In conclusion, our results suggest that dietary menthol can protect against inflammation and cardiac remodeling after MI through activation of TRPM8.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpz162","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T11:07:57Z","timestamp":1571310477000},"page":"223-233","source":"Crossref","is-referenced-by-count":20,"title":["Dietary Menthol Attenuates Inflammation and Cardiac Remodeling After Myocardial Infarction via the Transient Receptor Potential Melastatin 8"],"prefix":"10.1093","volume":"33","author":[{"given":"Qiang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command , Chengdu, Sichuan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Chengdu Medical College , Chengdu, Sichuan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command , Chengdu, Sichuan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command , Chengdu, Sichuan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command , Chengdu, Sichuan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command , Chengdu, Sichuan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command , Chengdu, Sichuan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command , Chengdu, Sichuan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dachun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command , Chengdu, Sichuan, PR 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