{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:44:45Z","timestamp":1779371085199,"version":"3.53.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100018488","name":"UF Clinical and Translational Science Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018488","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001427"],"award-info":[{"award-number":["UL1TR001427"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK104721"],"award-info":[{"award-number":["T32 DK104721"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2 TR001429"],"award-info":[{"award-number":["KL2 TR001429"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Specific combinations of two drug classes are recommended in a variety of clinical situations in the management of hypertension. These preferred combinations are based on complimentary blood pressure (BP) lowering mechanisms or benefit for a concomitant disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Using electronic health records (EHRs) data from 27,579 ambulatory hypertensive patients, we investigated antihypertensive therapy prescribing patterns and associations of preferred two drug classes with BP control.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Overall, BP control, defined as BP &amp;lt;140\/90 mm Hg, was 65% among treated patients. Preferred dual antihypertensive therapy was prescribed in 55% of patients with uncomplicated hypertension, 49% of patients with diabetes, and 47% of patients with a history of myocardial infarction (MI); these prescribing frequencies of preferred combinations were not explained by worse BP control on those combinations. In fact, we found suggestive evidence of association between prescribing of preferred two drug classes and improved BP control among post-MI (OR: 1.21, 95% CI: 0.99\u20131.48, P = 0.061) and uncomplicated hypertensive (OR: 1.11, 95% CI: 0.98\u20131.26, P = 0.089) patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Prescribing of guideline-recommended antihypertensive drug classes for concomitant diseases is suboptimal and prescribing of preferred\/optimized drug class combinations was moderate. We did not find a clear association between the use of optimized drug class combinations and greater BP control. Overall, using EHR data, we identified potential opportunities for re-examining prescribing practices with implications for clinical decision support and healthcare improvement at the community and health system-wide levels.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpz196","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T12:11:02Z","timestamp":1576584662000},"page":"316-324","source":"Crossref","is-referenced-by-count":10,"title":["Combination Antihypertensive Therapy Prescribing and Blood Pressure Control in a Real-World Setting"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2426-9157","authenticated-orcid":false,"given":"Oyunbileg","family":"Magvanjav","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy , Gainesville, Florida, USA"},{"name":"Department of Medicine, University of Florida College of Medicine , Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda M","family":"Cooper-Dehoff","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy , Gainesville, Florida, USA"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine , Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitrin W","family":"McDonough","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy , Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy , Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Hogan","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine , Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy , Gainesville, Florida, USA"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine , Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,19]]},"reference":[{"key":"2022100620371640800_CIT0001","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(15)01225-8","article-title":"Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis","volume":"387","author":"Ettehad","year":"2016","journal-title":"Lancet"},{"key":"2022100620371640800_CIT0002","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jacc.2017.10.073","article-title":"Potential U.S. population impact of the 2017 ACC\/AHA high blood pressure guideline","volume":"71","author":"Muntner","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2022100620371640800_CIT0003","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jash.2013.07.009","article-title":"Review of blood pressure control rates and outcomes","volume":"8","author":"Bakris","year":"2014","journal-title":"J Am Soc Hypertens"},{"key":"2022100620371640800_CIT0004","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/HYPERTENSIONAHA.111.177592","article-title":"Cardiovascular protection by initial and subsequent combination of antihypertensive drugs in daily life practice","volume":"58","author":"Corrao","year":"2011","journal-title":"Hypertension"},{"key":"2022100620371640800_CIT0005","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1097\/HJH.0b013e328339f9fa","article-title":"Reduced discontinuation of antihypertensive treatment by two-drug combination as first step. 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