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It is used in the synthesis of the thyroid hormones thyroxine and triiodothyroxine. Patients who report having adverse reactions to iodine-containing substances are often labelled as having an \u201ciodine allergy,\u201d which can result in delays in care or patients being denied essential iodinated contrast media (ICM) or other iodine-containing drugs. A literature review was conducted to evaluate the evidence regarding iodine allergy and iodine-containing drugs. Of 435 articles considered potentially appropriate for full review (plus 12 additional articles included on the basis of references from the eligible articles), 113 could not be obtained. After exclusion of 353 articles that did not meet all inclusion criteria, the remaining 81 articles were included in the review. The results of the literature review indicated that iodine has not been shown to be the allergen responsible for allergic reactions to iodinated contrast media, amiodarone, povidone-iodine, and other iodine-containing compounds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a lack of evidence to support cross-reactivity between iodine-containing compounds in so called iodine-allergic individuals.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ajhp\/zxab033","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T12:49:07Z","timestamp":1612615747000},"page":"781-793","source":"Crossref","is-referenced-by-count":37,"title":["Iodine allergy: Common misperceptions"],"prefix":"10.1093","volume":"78","author":[{"given":"Nicole R","family":"Wulf","sequence":"first","affiliation":[{"name":"First Databank, South San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Choi","sequence":"additional","affiliation":[{"name":"Stanson Health, Charlotte, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Kapusnik-Uner","sequence":"additional","affiliation":[{"name":"First Databank, South San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,6]]},"reference":[{"key":"2021042211440089100_CIT0001","doi-asserted-by":"crossref","first-page":"158.e1","DOI":"10.1016\/j.amjmed.2007.08.025","article-title":"Seafood allergy and radiocontrast media: are physicians propagating a myth?","volume":"121","author":"Beaty","year":"2008","journal-title":"Am J 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