{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:39:11Z","timestamp":1788691151694,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100018488","name":"University of Florida Clinical and Translational Science Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001427"],"award-info":[{"award-number":["UL1TR001427"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>To identify the incidence of continuation of newly initiated loop diuretics upon intensive care unit (ICU) and hospital discharge and identify factors associated with continuation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a single-center retrospective study using electronic health records in the setting of adult ICUs at a quaternary care academic medical center. It involved patients with sepsis admitted to the ICU from January 1, 2014, to June 30, 2019, who received intravenous fluid resuscitation. The endpoints of interest were (1) the incidence of loop diuretic use during an ICU stay following fluid resuscitation, (2) continuation of loop diuretics following transition of care, and (3) potential factors associated with loop diuretic continuation after transition from the ICU.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 3,591 patients who received intravenous fluid resuscitation for sepsis, 39.4% (n = 1,415) were newly started on loop diuretics during their ICU stay. Among patients who transitioned to the hospital ward from the ICU, loop diuretics were continued in 33% (388\/1,193) of patients. At hospital discharge, 13.4% (52\/388) of these patients were prescribed a loop diuretic to be used in the outpatient setting. History of liver disease, development of acute kidney injury, being on vasopressors while in the ICU, receiving blood products, and receiving greater than 90 mL\/kg of bolus fluids were significant potential factors associated with loop diuretic continuation after transition from the ICU.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>New initiation of loop diuretics following intravenous fluid resuscitation in patients with sepsis during an ICU stay is a common occurrence. Studies are needed to assess the effect of this practice on patient outcomes and resource utilization.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajhp\/zxab372","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T12:21:32Z","timestamp":1632399692000},"page":"165-172","source":"Crossref","is-referenced-by-count":11,"title":["Loop diuretic use following fluid resuscitation in the critically ill"],"prefix":"10.1093","volume":"79","author":[{"given":"Mashael A","family":"Alaskar","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy, Center for Drug Evaluation & Safety, University of Florida, College of Pharmacy , Gainesville, FL, USA"},{"name":"King Faisal Specialist Hospital and Research Centre, Riyadh,Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy, Center for Drug Evaluation & Safety, University of Florida, College of Pharmacy , Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy A","family":"Voils","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, Gainesville, FL,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M","family":"Vouri","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy, Center for Drug Evaluation & Safety, University of Florida, College of Pharmacy , Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"issue":"3","key":"2022012512171000800_CIT0001","first-page":"304","article-title":"Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 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