{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:06:41Z","timestamp":1772600801236,"version":"3.50.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"Supplement_4","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,23]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n The impact of pharmacist-led culture follow-up programs for positive cultures is well established. The benefits and feasibility of evaluating negative cultures and deprescribing unnecessary antibiotics after emergency department (ED) and urgent care (UC) visits are unknown; therefore, this evaluation characterized the burden of negative urine cultures and chlamydia tests and estimated how many potential antibiotic days could be saved with deprescribing.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective, descriptive study evaluated patients discharged from an ED or UC location with a pharmacist-led culture follow-up program. The primary objective was to characterize the proportion of patients with a negative urine culture or chlamydia test where an opportunity would exist to deprescribe antibiotics at follow-up. Secondary endpoints included estimating the number of potential antibiotic days that could be saved, postvisit healthcare utilization, and documented adverse drug reactions (ADRs).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n For a 1-month period, pharmacists reviewed 398 cultures, of which 208 (52%) were urine cultures or chlamydia tests with negative results. Fifty patients (24%) with negative results had been prescribed empiric antibiotics. The median duration of antibiotic treatment was 7 days (interquartile range [IQR], 5-7 days), while the median time to culture finalization was 2 days (IQR, 1-2 days). There was an opportunity to save a median of 5 antibiotic days per patient. Thirty-two patients (15.3%) followed up with their primary care physician within 7 days; of these patients, 1 (0.05%) had their antibiotic prescription discontinued by the primary care physician. There were no documented ADRs.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Expansion of pharmacist-led culture follow-up programs to deprescribe antibiotics for patients with negative cultures has the potential to save significant antibiotic exposure.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ajhp\/zxad063","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T16:37:58Z","timestamp":1680021478000},"page":"S151-S156","source":"Crossref","is-referenced-by-count":5,"title":["Feasibility evaluation to expand a collaborative practice agreement and discontinue antibiotics after an emergency department or urgent care visit"],"prefix":"10.1093","volume":"80","author":[{"given":"Abigail C","family":"Geyer","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Trinity Health Grand Rapids , Grand Rapids, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather M","family":"Draper","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Trinity Health Grand Rapids , Grand Rapids, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren M","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Trinity Health Grand Rapids , Grand Rapids, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige M","family":"Buss","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Trinity Health Grand Rapids , Grand Rapids, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa E","family":"Dumkow","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Trinity Health Grand Rapids , Grand Rapids, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"2023112820373183500_CIT0001","volume-title":"Antibiotic Resistance 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Pharm"},{"issue":"3","key":"2023112820373183500_CIT0009","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s40121-017-0168-8","article-title":"Expanding antimicrobial stewardship to urgent care centers through a pharmacist-led culture follow-up program","volume":"6","author":"Dumkow","year":"2017","journal-title":"Infect Dis Ther"}],"container-title":["American Journal of Health-System 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