{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:58:11Z","timestamp":1790114291752,"version":"4.0.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>Emergency department (ED) pharmacists commonly perform positive culture follow-ups that result in optimized antibiotic prescribing. The purpose of this study was to evaluate the potential positive impact on the outcome of antibiotic-free days through an ED pharmacist\u2013driven protocol to contact patients with negative urine cultures and sexually transmitted infection (STI) test results who were discharged with antibiotics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a single-center, prospective, observational, pre-post intervention study to determine antibiotic use in patients with negative urine cultures who were discharged from the Loyola Medical University Center ED with antibiotics prescribed. Patients were identified through daily positive culture reports. The primary outcome was days free of antibiotics, defined as the number of calendar days within 28 days after urine culture or STI test collection on which the patient did not receive any antibiotic treatments.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>One hundred ninety-two patients were screened. Sixty-three and twenty-six patients met the inclusion criteria in the pre- and postintervention groups, respectively. The study identified 163\/465 (35.1%) antibiotic free days for the preintervention group, compared to 150.5\/187 (80.5%) antibiotic-free days for the postintervention group. A majority of the patients did not have urinary tract infection as the chief complaint. The most common urinary and STI symptoms upon ED admission in the pre- and postintervention groups were dysuria (19.2% vs 28.1%) and unusual discharge (30.8% vs 28.6%), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study showed that a pharmacist-driven protocol increased the number of antibiotic-free days for patients prescribed empiric antibiotic therapy and discharged from the ED with subsequent negative urine cultures and STI results. We propose taking a novel approach in discontinuation of antibiotics by implementing an expansion of ED culture programs to include negative cultures that promote antimicrobial stewardship.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajhp\/zxad255","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T16:52:45Z","timestamp":1698252765000},"page":"e83-e89","source":"Crossref","is-referenced-by-count":9,"title":["A pharmacist-driven deprescribing protocol for negative urine and sexually transmitted infection cultures in the emergency department increases antibiotic-free days"],"prefix":"10.1093","volume":"81","author":[{"given":"Yifan","family":"Wang","sequence":"first","affiliation":[{"name":"College of Medicine, University of Illinois at Chicago , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlie","family":"Knobloch","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Michigan Hospital , Ann Arbor, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Lovett","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Stritch School of Medicine, Loyola University Chicago , Maywood, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Loyola University Medical Center , Maywood, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan A","family":"Rech","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs, Center of Innovation for Complex Chronic Healthcare, Edward Hines, Jr. VA Hospital , Hines, IL , USA"},{"name":"Department of Emergency Medicine, Stritch School of Medicine, Loyola University Chicago , Maywood, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"2024012419563423600_CIT0001","author":"Centers for Disease Control and Prevention","year":"2020"},{"key":"2024012419563423600_CIT0002","author":"Centers for Disease Control and Prevention","year":"2022"},{"issue":"12","key":"2024012419563423600_CIT0003","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1345\/aph.1H448","article-title":"The state of US emergency care: a call to action for hospital pharmacists","volume":"40","author":"Idrees","year":"2006","journal-title":"Ann Pharmacother"},{"issue":"5","key":"2024012419563423600_CIT0004","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.2146\/sp150036","article-title":"Laine GA. 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