{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:06:23Z","timestamp":1789517183363,"version":"build-2803163510"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>Short bowel syndrome is a malabsorptive condition that occurs due to surgical removal or a congenital absence of a significant portion of the small intestine. Patients with short bowel syndrome often rely on parenteral support for extended periods or even their entire lives. Teduglutide, a glucagon-like peptide-2 analog, has shown promising results in reducing dependency on parenteral support in these patients by promoting intestinal adaptation and enhancing nutrient absorption. However, the long-term safety of teduglutide remains a concern, particularly with respect to its potential for the development of hyperamylasemia and hyperlipasemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study involved patients who received teduglutide from December 2012 to December 2022 at Boston Medical Center. We evaluated outcomes and adverse events, focusing on hyperamylasemia and hyperlipasemia, through chart review.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thirteen eligible patients were identified who had used teduglutide. Of these, the majority (84.6%) experienced a reduction in parenteral support. A high incidence (72.7%) of nonpathological pancreatic enzyme elevation was observed in patients treated with teduglutide. These elevations were often dose dependent and were not associated with any clinical signs of acute pancreatitis or abnormal imaging findings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study highlights the need for further investigations into the long-term safety of teduglutide and the importance of closely monitoring amylase and lipase levels in patients undergoing treatment with teduglutide.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajhp\/zxad274","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T11:44:07Z","timestamp":1699530247000},"page":"146-152","source":"Crossref","is-referenced-by-count":4,"title":["Long-term outcomes and adverse effects of teduglutide in patients with short bowel syndrome: Highlighting hyperamylasemia and hyperlipasemia"],"prefix":"10.1093","volume":"81","author":[{"given":"Dong Wook","family":"Kim","sequence":"first","affiliation":[{"name":"Section of Endocrinology, Diabetes, Nutrition, and Weight Management, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine , Boston, MA"},{"name":"Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunju","family":"Kim","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, Nutrition, and Weight Management, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Bertram","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, Nutrition, and Weight Management, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Sungku","family":"Rim","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, Nutrition, and Weight Management, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Nolen-Doerr","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, Nutrition, and Weight Management, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Hun","family":"Shin","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, Nutrition, and Weight Management, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, and Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Hanyang University Guri Hospital , Guri , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"key":"2024020820294060300_CIT0001"},{"issue":"7","key":"2024020820294060300_CIT0002","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1136\/gut.2010.218271","article-title":"Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and\/or intravenous fluid requirements in patients with short bowel syndrome","volume":"60","author":"Jeppesen","year":"2011","journal-title":"Gut"},{"issue":"6","key":"2024020820294060300_CIT0003","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1177\/0148607116680791","article-title":"Independence from parenteral nutrition and intravenous fluid support during treatment with teduglutide among patients with intestinal failure associated with short bowel syndrome","volume":"41","author":"Iyer","year":"2017","journal-title":"J Parenter Enteral Nutr"},{"issue":"7","key":"2024020820294060300_CIT0004","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.cgh.2012.12.029","article-title":"Safety and efficacy of teduglutide after 52 weeks of treatment in patients with short bowel intestinal failure","volume":"11","author":"O\u2019Keefe","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"8","key":"2024020820294060300_CIT0005","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.3390\/nu14081634","article-title":"Changes in parenteral nutrition requirements and BMI in patients with parenteral nutrition-dependent short bowel syndrome after stopping teduglutide\u20149 years of follow-up","volume":"14","author":"Zaczek","year":"2022","journal-title":"Nutrients"},{"issue":"6","key":"2024020820294060300_CIT0006","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/MCG.0000000000000604","article-title":"Safety and efficacy of teduglutide (Gattex) in patients with Crohn\u2019s disease and need for parenteral support due to short bowel syndrome-associated intestinal failure","volume":"51","author":"Kochar","year":"2017","journal-title":"J Clin Gastroenterol"},{"issue":"5","key":"2024020820294060300_CIT0007","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/ccr3.2127","article-title":"Dose-dependent elevation in amylase and lipase in response to teduglutide administration","volume":"7","author":"Lee","year":"2019","journal-title":"Clin Case Rep"},{"issue":"2","key":"2024020820294060300_CIT0008","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.1038\/ctg.2015.69","article-title":"Long-term teduglutide for the treatment of patients with intestinal failure associated with short bowel syndrome","volume":"7","author":"Schwartz","year":"2016","journal-title":"Clin Transl Gastroenterol"},{"issue":"6","key":"2024020820294060300_CIT0009","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1097\/MPG.0000000000002899","article-title":"Experience with teduglutide in pediatric short bowel syndrome: first real-life data","volume":"71","author":"Ramos Boluda","year":"2020","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"2024020820294060300_CIT0010","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1053\/j.gastro.2012.09.007","article-title":"Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure","volume":"143","author":"Jeppesen","year":"2012","journal-title":"Gastroenterology"},{"issue":"12","key":"2024020820294060300_CIT0011","doi-asserted-by":"crossref","first-page":"e00257","DOI":"10.14309\/ctg.0000000000000257","article-title":"Glucagon-like peptide 2 inhibits postprandial gallbladder emptying in man: a randomized, double-blinded, crossover study","volume":"11","author":"Hansen","year":"2020","journal-title":"Clin Transl Gastroenterol"},{"key":"2024020820294060300_CIT0012","doi-asserted-by":"crossref","first-page":"1756284820905766","DOI":"10.1177\/1756284820905766","article-title":"Teduglutide for the treatment of adults with intestinal failure associated with short bowel syndrome: pooled safety data from four clinical trials","volume":"13","author":"Pape","year":"2020","journal-title":"Therap Adv Gastroenterol"},{"issue":"3","key":"2024020820294060300_CIT0013","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1053\/gast.2000.16489","article-title":"Enteroendocrine localization of GLP-2 receptor expression in humans and rodents","volume":"119","author":"Yusta","year":"2000","journal-title":"Gastroenterology"},{"issue":"1","key":"2024020820294060300_CIT0014","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00006676-199801000-00008","article-title":"A comparison of lipase and amylase in the diagnosis of acute pancreatitis in patients with abdominal pain","volume":"16","author":"Keim","year":"1998","journal-title":"Pancreas"},{"issue":"8","key":"2024020820294060300_CIT0015","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/ijo.2017.77","article-title":"Increased GLP2R expression in gastric chief cells of patients with severe obesity regardless of diabetes status","volume":"41","author":"Li","year":"2017","journal-title":"Int J Obes"},{"key":"2024020820294060300_CIT0016","first-page":"99","article-title":"Significant elevations of serum lipase not caused by pancreatitis: a systematic review. HPB","author":"Hameed","year":"2015"},{"issue":"6","key":"2024020820294060300_CIT0017","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1053\/gast.1996.v110.pm8964417","article-title":"Chronic nonpathological hyperamylasemia of pancreatic origin","volume":"110","author":"Gullo","year":"1996","journal-title":"Gastroenterology"},{"issue":"2","key":"2024020820294060300_CIT0018","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/00006676-200003000-00008","article-title":"Familial pancreatic hyperenzymemia","volume":"20","author":"Gullo","year":"2000","journal-title":"Pancreas"},{"issue":"1","key":"2024020820294060300_CIT0019","first-page":"230","article-title":"Hernia enlargement and pancreatitis in a patient with short bowel syndrome treated with teduglutide","volume":"39","author":"Conejo","year":"2022","journal-title":"Nutr Hosp"}],"container-title":["American Journal of Health-System Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajhp\/advance-article-pdf\/doi\/10.1093\/ajhp\/zxad274\/54463280\/zxad274.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajhp\/article-pdf\/81\/4\/146\/56629138\/zxad274.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajhp\/article-pdf\/81\/4\/146\/56629138\/zxad274.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T20:29:59Z","timestamp":1707424199000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajhp\/article\/81\/4\/146\/7370955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,6]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,11,6]]},"published-print":{"date-parts":[[2024,2,8]]}},"URL":"https:\/\/doi.org\/10.1093\/ajhp\/zxad274","relation":{},"ISSN":["1079-2082","1535-2900"],"issn-type":[{"value":"1079-2082","type":"print"},{"value":"1535-2900","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2,15]]},"published":{"date-parts":[[2023,11,6]]}}}