{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:48:24Z","timestamp":1789645704609,"version":"4.0.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Cefdinir and cephalexin are cephalosporin antibiotics commonly used in the treatment of urinary tract infections (UTIs). Their efficacy depends on achieving sufficient time with concentrations exceeding the minimum inhibitory concentration (MIC). Despite being frequently prescribed for UTIs, cefdinir has markedly lower urine penetration compared to cephalexin. It is possible that differences in pharmacokinetics could result in dissimilar efficacy between these agents; however, comparative studies of cephalosporins in UTIs are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective comparative study of patients discharged from emergency departments within a community health system with a diagnosis of acute cystitis who were prescribed cefdinir or cephalexin. Treatment failure rates at 7 and 14 days were compared between the 2 agents using a \u03c72 or Fisher\u2019s exact test, as appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no differences in overall treatment failure between the cefdinir and cephalexin groups. Treatment failure at 7 days occurred in 11.6% (n = 14) of patients in the cefdinir group and 8.3% (n = 10) of patients in the cephalexin group (P = 0.389). Treatment failure at 14 days was higher for cefdinir at 20.7% (n = 25) than for cephalexin at 11.8% (n = 14), but this difference was not statistically significant (P = 0.053). There were no differences in the rate of treatment failure in subgroup analyses of uncomplicated or complicated UTIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this study suggest that cefdinir and cephalexin have comparable efficacy for the treatment of lower UTIs. While there was a numerically higher rate of treatment failure with cefdinir, there were no significant differences in treatment failure between the agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajhp\/zxae026","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T17:10:20Z","timestamp":1707498620000},"page":"S55-S60","source":"Crossref","is-referenced-by-count":9,"title":["Cefdinir vs cephalexin for the treatment of urinary tract infections: A retrospective evaluation"],"prefix":"10.1093","volume":"81","author":[{"given":"Andie","family":"Lloyd","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Mease Countryside Hospital , Safety Harbor, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Grey","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mease Countryside Hospital , Safety Harbor, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Fronczek","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mease Countryside Hospital , Safety Harbor, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Durkin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mease Countryside Hospital , Safety Harbor, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Marr","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mease Countryside Hospital , Safety Harbor, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"issue":"4","key":"2024052407050642800_CIT0001","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/01.ju.0000155596.98780.82","article-title":"Urologic Diseases in America Project: trends in resource use for urinary tract infections in women","volume":"173","author":"Griebling","year":"2005","journal-title":"J Urol"},{"issue":"10","key":"2024052407050642800_CIT0002","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1002\/pds.5237","article-title":"Rate of antibiotic treatment failure in premenopausal women with uncomplicated urinary tract infection","volume":"30","author":"Butler","year":"2021","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"5","key":"2024052407050642800_CIT0003","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1093\/cid\/ciq257","article-title":"International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases","volume":"52","author":"Gupta","year":"2011","journal-title":"Clin Infect Dis"},{"key":"2024052407050642800_CIT0004","author":"Omnicef (cefdinir)"},{"key":"2024052407050642800_CIT0005","author":"Keflex (cephalexin)"},{"issue":"1","key":"2024052407050642800_CIT0006","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/00099228221112055","article-title":"Retrospective comparison of cefdinir, cephalexin, and sulfamethoxazole-trimethoprim in the treatment of outpatient pediatric urinary tract infections","volume":"62","author":"Cardinale","year":"2023","journal-title":"Clin Pediatr"},{"issue":"11","key":"2024052407050642800_CIT0007","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1128\/AAC.38.11.2612","article-title":"Single-dose fosfomycin trometamol versus 5-day cephalexin regimen for treatment of uncomplicated lower urinary tract infections in women","volume":"38","author":"Elhanan","year":"1994","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"2024052407050642800_CIT0008","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1365-2125.2004.02106.x","article-title":"Increased treatment failure after 3-days\u2019 courses of nitrofurantoin and trimethoprim for urinary tract infections in women: a population-based retrospective cohort study using the PHARMO database","volume":"58","author":"Goettsch","year":"2004","journal-title":"Br J Clin Pharmacol"},{"issue":"28","key":"2024052407050642800_CIT0009","doi-asserted-by":"crossref","first-page":"e304","DOI":"10.1097\/MD.0000000000000304","article-title":"Comparative effectiveness of different oral antibiotics regimens for treatment of urinary tract infection in outpatients: an analysis of national representative claims database","volume":"93","author":"Lee","year":"2014","journal-title":"Medicine"},{"issue":"7","key":"2024052407050642800_CIT0010","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0149-2918(00)80054-5","article-title":"Cefdinir versus cefaclor in the treatment of uncomplicated urinary tract infection","volume":"22","author":"Leigh","year":"2000","journal-title":"Clin Ther"}],"container-title":["American Journal of Health-System Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajhp\/advance-article-pdf\/doi\/10.1093\/ajhp\/zxae026\/56732539\/zxae026.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajhp\/article-pdf\/81\/Supplement_2\/S55\/57837382\/zxae026.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajhp\/article-pdf\/81\/Supplement_2\/S55\/57837382\/zxae026.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T03:41:49Z","timestamp":1716522109000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajhp\/article\/81\/Supplement_2\/S55\/7607125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":10,"journal-issue":{"issue":"Supplement_2","published-online":{"date-parts":[[2024,2,13]]},"published-print":{"date-parts":[[2024,5,24]]}},"URL":"https:\/\/doi.org\/10.1093\/ajhp\/zxae026","relation":{},"ISSN":["1079-2082","1535-2900"],"issn-type":[{"value":"1079-2082","type":"print"},{"value":"1535-2900","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6,1]]},"published":{"date-parts":[[2024,2,13]]}}}