{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T02:46:19Z","timestamp":1793846779314,"version":"4.6.1"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe the systemic benefits of sugammadex as a reversal agent for neuromuscular blockade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Sugammadex is the preferred reversal agent for neuromuscular blockade as recommended in guidelines from the American Society of Anesthesiology. This recommendation is primarily based on a faster time to recovery from neuromuscular blockade as compared to that seen with neostigmine. Systemic adverse effects of neostigmine are often mitigated by the administration of glycopyrrolate. However, glycopyrrolate is an antimuscarinic agent that may be associated with its own adverse effects when used as part of a reversal strategy for neuromuscular blockade. This review describes the potential systemic benefits of sugammadex, compared to an acetylcholinesterase\/anticholinergic strategy, related to postoperative nausea and vomiting, urinary retention, bowel recovery, and cognitive dysfunction while also discussing its role in enhanced recovery after surgery protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sugammadex is associated with a reduction in systemic effects when compared to combinations of neostigmine and glycopyrrolate. Further research is needed on important clinical and economic outcomes associated with a reduction in these adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajhp\/zxaf213","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T11:51:14Z","timestamp":1755258674000},"page":"e183-e191","source":"Crossref","is-referenced-by-count":3,"title":["Postoperative benefits of sugammadex: A narrative review"],"prefix":"10.1093","volume":"83","author":[{"given":"Dustin D","family":"Linn","sequence":"first","affiliation":[{"name":"Philips North America , Cambridge, MA"},{"name":"Department of Pharmacy, Parkview Health , Fort Wayne, IN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Ross","family":"Renew","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic , Jacksonville, FL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"2026021918514131300_zxaf213-B1","doi-asserted-by":"publisher","first-page":"e6329","DOI":"10.1136\/bmj.e6329","article-title":"Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study","volume":"345","author":"Grosse-Sundrup","year":"2012","journal-title":"BMJ"},{"issue":"6","key":"2026021918514131300_zxaf213-B2","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1097\/ALN.0000000000000674","article-title":"Dose-dependent association between intermediate-acting neuromuscular-blocking agents and postoperative respiratory complications","volume":"122","author":"McLean","year":"2015","journal-title":"Anesthesiology"},{"issue":"4","key":"2026021918514131300_zxaf213-B3","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1097\/ALN.0000000000001279","article-title":"Nondepolarizing neuromuscular blocking agents, reversal, and risk of postoperative pneumonia","volume":"125","author":"Bulka","year":"2016","journal-title":"Anesthesiology"},{"issue":"1","key":"2026021918514131300_zxaf213-B4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/ALN.0000000000004379","article-title":"2023 American Society of Anesthesiologists practice guidelines for monitoring and antagonism of neuromuscular blockade: a report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade","volume":"138","author":"Thilen","year":"2023","journal-title":"Anesthesiology"},{"issue":"2","key":"2026021918514131300_zxaf213-B5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1097\/EJA.0000000000001769","article-title":"Peri-operative management of neuromuscular blockade: a guideline from the European Society of Anaesthesiology and Intensive Care","volume":"40","author":"Fuchs-Buder","year":"2023","journal-title":"Eur J Anaesthesiol"},{"issue":"8","key":"2026021918514131300_zxaf213-B6","doi-asserted-by":"publisher","first-page":"CD012763","DOI":"10.1002\/14651858.CD012763","article-title":"Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults","volume":"8","author":"Hristovska","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"2026021918514131300_zxaf213-B7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12871-024-02512-x","article-title":"The effect of glycopyrrolate vs. atropine in combination with neostigmine on cardiovascular system for reversal of residual neuromuscular blockade in the elderly: a randomized controlled trial","volume":"24","author":"Wang","year":"2024","journal-title":"BMC Anesthesiol"},{"issue":"5","key":"2026021918514131300_zxaf213-B8","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s00540-020-02836-1","article-title":"History of the development of antagonists for neuromuscular blocking agents","volume":"34","author":"Suzuki","year":"2020","journal-title":"J Anesth"},{"key":"2026021918514131300_zxaf213-B9"},{"issue":"3","key":"2026021918514131300_zxaf213-B10","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1097\/00000542-199909000-00022","article-title":"A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers","volume":"91","author":"Apfel","year":"1999","journal-title":"Anesthesiology"},{"issue":"1","key":"2026021918514131300_zxaf213-B11","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1093\/oxfordjournals.bja.a013383","article-title":"Patient satisfaction after anaesthesia and surgery: results of a prospective survey of 10,811 patients","volume":"84","author":"Myles","year":"2000","journal-title":"Br J Anaesth"},{"issue":"2","key":"2026021918514131300_zxaf213-B12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1213\/ANE.0000000000004833","article-title":"Fourth consensus guidelines for the management of postoperative nausea and vomiting","volume":"131","author":"Gan","year":"2020","journal-title":"Anesth Analg"},{"issue":"5","key":"2026021918514131300_zxaf213-B13","doi-asserted-by":"publisher","first-page":"434","DOI":"10.23736\/S0375-9393.22.16972-5","article-title":"The effect of sugammadex versus neostigmine on postoperative nausea and vomiting: a meta-analysis of randomized controlled trials with trial sequential analysis","volume":"89","author":"Hsieh","year":"2023","journal-title":"Minerva Anestesiol"},{"issue":"1","key":"2026021918514131300_zxaf213-B14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2174\/1574886318666230302124634","article-title":"Sugammadex versus neostigmine for reversal of neuromuscular blockade in adults and children: a systematic review and meta-analysis of randomized controlled trials","volume":"19","author":"Chhabra","year":"2024","journal-title":"Curr Drug Saf"},{"issue":"6","key":"2026021918514131300_zxaf213-B15","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1177\/00031348241227200","article-title":"Postoperative gastrointestinal dysfunction after neuromuscular blockade reversal with sugammadex versus cholinesterase inhibitors in patients undergoing gastrointestinal surgery: a systematic review and meta-analysis","volume":"90","author":"Sharma","year":"2024","journal-title":"Am Surg"},{"issue":"5","key":"2026021918514131300_zxaf213-B16","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1097\/ALN.0b013e31819f7aea","article-title":"Postoperative urinary retention: anesthetic and perioperative considerations","volume":"110","author":"Baldini","year":"2009","journal-title":"Anesthesiology"},{"issue":"5","key":"2026021918514131300_zxaf213-B17","doi-asserted-by":"publisher","first-page":"e1900149","DOI":"10.5435\/JAAOSGlobal-D-19-00149","article-title":"Incidence, outcomes, and prediction of postoperative urinary retention after a nonurologic procedure","volume":"4","author":"Abdul-Muhsin","year":"2020","journal-title":"J Am Acad Orthop Surg Glob Res Rev"},{"issue":"2","key":"2026021918514131300_zxaf213-B18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.amjsurg.2011.11.012","article-title":"National incidence and outcomes of postoperative urinary retention in the Surgical Care Improvement Project","volume":"204","author":"Wu","year":"2012","journal-title":"Am J Surg"},{"issue":"3","key":"2026021918514131300_zxaf213-B19","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1177\/2192568220904681","article-title":"Evaluation of risk factors for postoperative urinary retention in elective thoracolumbar spinal fusion patients","volume":"11","author":"Strickland","year":"2021","journal-title":"Glob Spine J"},{"issue":"22","key":"2026021918514131300_zxaf213-B20","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1097\/BRS.0000000000000572","article-title":"Patient and surgical factors associated with postoperative urinary retention after lumbar spine surgery","volume":"39","author":"Gandhi","year":"2014","journal-title":"Spine"},{"issue":"12","key":"2026021918514131300_zxaf213-B21","doi-asserted-by":"publisher","first-page":"3874","DOI":"10.1007\/s00268-018-4697-4","article-title":"Prospective risk factor analysis for the development of post-operative urinary retention following ambulatory general surgery","volume":"42","author":"Scott","year":"2018","journal-title":"World J Surg"},{"issue":"4","key":"2026021918514131300_zxaf213-B22","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.jopan.2023.05.006","article-title":"Pharmacologic management of postoperative urinary retention","volume":"38","author":"Wolfe","year":"2023","journal-title":"J Perianesthesia Nurs"},{"issue":"1","key":"2026021918514131300_zxaf213-B23","doi-asserted-by":"publisher","first-page":"40","DOI":"10.17085\/apm.2018.13.1.40","article-title":"Sugammadex use can decrease the incidence of post-operative urinary retention by avoiding anticholinergics: a retrospective study","volume":"13","author":"Cha","year":"2018","journal-title":"Anesth Pain Med"},{"issue":"5","key":"2026021918514131300_zxaf213-B24","doi-asserted-by":"publisher","first-page":"938","DOI":"10.3390\/jcm10050938","article-title":"Quality of recovery after laparoscopic cholecystectomy following neuromuscular blockade reversal with neostigmine or sugammadex: a prospective, randomized, controlled trial","volume":"10","author":"Han","year":"2021","journal-title":"J Clin Med"},{"issue":"5","key":"2026021918514131300_zxaf213-B25","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1097\/SLE.0000000000000962","article-title":"Urinary retention following inguinal herniorrhaphy: role of neuromuscular blockade reversal","volume":"31","author":"Valencia Morales","year":"2021","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"issue":"1","key":"2026021918514131300_zxaf213-B26","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s13019-022-01936-1","article-title":"A comparison of neuromuscular blockade and reversal using cisatricurium and neostigmine with rocuronium and sugamadex on the quality of recovery from general anaesthesia for percutaneous closure of left atria appendage","volume":"17","author":"Li","year":"2022","journal-title":"J Cardiothorac Surg"},{"issue":"12","key":"2026021918514131300_zxaf213-B27","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1016\/j.jfma.2022.04.017","article-title":"Sugammadex reversal of muscle relaxant blockade provided less post-anesthesia care unit adverse effects than neostigmine\/glycopyrrolate","volume":"121","author":"Chang","year":"2022","journal-title":"J Formos Med Assoc Taiwan Yi Zhi"},{"key":"2026021918514131300_zxaf213-B28","doi-asserted-by":"publisher","first-page":"1072711","DOI":"10.3389\/fmed.2022.1072711","article-title":"Sugammadex versus neostigmine for neuromuscular blockade reversal in outpatient surgeries: a randomized controlled trial to evaluate efficacy and associated healthcare cost in an academic center","volume":"9","author":"Fiorda Diaz","year":"2022","journal-title":"Front Med"},{"issue":"5","key":"2026021918514131300_zxaf213-B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00192-023-05668-1","article-title":"The effect of sugammadex on postoperative urinary retention post-laparoscopic and robotic hysterectomy with and without concomitant procedures","volume":"35","author":"Due\u00f1as-Garcia","year":"2024","journal-title":"Int Urogynecology J"},{"key":"2026021918514131300_zxaf213-B30","doi-asserted-by":"publisher","first-page":"111344","DOI":"10.1016\/j.jclinane.2023.111344","article-title":"Post-operative urinary retention is impacted by neuromuscular block reversal agent choice: a retrospective cohort study in US hospital setting","volume":"93","author":"Bash","year":"2024","journal-title":"J Clin Anesth"},{"issue":"5","key":"2026021918514131300_zxaf213-B31","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1007\/s11605-013-2148-y","article-title":"Defining postoperative ileus: results of a systematic review and global survey","volume":"17","author":"Vather","year":"2013","journal-title":"J Gastrointest Surg"},{"issue":"5","key":"2026021918514131300_zxaf213-B32","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s00384-017-2789-5","article-title":"Postoperative ileus in an enhanced recovery pathway-a retrospective cohort study","volume":"32","author":"Grass","year":"2017","journal-title":"Int J Colorectal Dis"},{"issue":"10","key":"2026021918514131300_zxaf213-B33","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1007\/s00384-013-1704-y","article-title":"Risk factors for the development of prolonged post-operative ileus following elective colorectal surgery","volume":"28","author":"Vather","year":"2013","journal-title":"Int J Colorectal Dis"},{"issue":"9","key":"2026021918514131300_zxaf213-B34","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1007\/s11605-015-2877-1","article-title":"Postoperative ileus\u2014more than just prolonged length of stay?","volume":"19","author":"Tevis","year":"2015","journal-title":"J Gastrointest Surg"},{"issue":"5","key":"2026021918514131300_zxaf213-B35","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1097\/DCR.0000000000001301","article-title":"Prolonged postoperative ileus significantly increases the cost of inpatient stay for patients undergoing elective colorectal surgery: results of a multivariate analysis of prospective data at a single institution","volume":"62","author":"Mao","year":"2019","journal-title":"Dis Colon Rectum"},{"issue":"3","key":"2026021918514131300_zxaf213-B36","doi-asserted-by":"publisher","first-page":"zrad054","DOI":"10.1093\/bjsopen\/zrad054","article-title":"Global cost of postoperative ileus following abdominal surgery: meta-analysis","volume":"7","author":"Traeger","year":"2023","journal-title":"BJS Open"},{"issue":"2","key":"2026021918514131300_zxaf213-B37","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.jamcollsurg.2009.09.028","article-title":"Postoperative ileus: it costs more than you expect","volume":"210","author":"Asgeirsson","year":"2010","journal-title":"J Am Coll Surg"},{"issue":"3","key":"2026021918514131300_zxaf213-B38","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00268-018-4844-y","article-title":"Guidelines for perioperative care in elective colorectal surgery: Enhanced Recovery After Surgery (ERAS) Society recommendations: 2018","volume":"43","author":"Gustafsson","year":"2019","journal-title":"World J Surg"},{"key":"2026021918514131300_zxaf213-B39","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jclinane.2016.03.010","article-title":"Reversal of neuromuscular blockade with sugammadex or neostigmine\/atropine: effect on postoperative gastrointestinal motility","volume":"32","author":"Sen","year":"2016","journal-title":"J Clin Anesth"},{"issue":"3","key":"2026021918514131300_zxaf213-B40","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.mayocpiqo.2019.06.003","article-title":"Effects of sugammadex on time of first postoperative bowel movement: a retrospective analysis","volume":"3","author":"Deljou","year":"2019","journal-title":"Mayo Clin Proc Innov Qual Outcomes"},{"issue":"2","key":"2026021918514131300_zxaf213-B41","doi-asserted-by":"publisher","first-page":"137","DOI":"10.4097\/kja.19360","article-title":"Neuromuscular blockade reversal with sugammadex versus pyridostigmine\/glycopyrrolate in laparoscopic cholecystectomy: a randomized trial of effects on postoperative gastrointestinal motility","volume":"73","author":"An","year":"2020","journal-title":"Korean J Anesthesiol"},{"issue":"12","key":"2026021918514131300_zxaf213-B42","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1177\/1060028020929061","article-title":"Effects on postoperative gastrointestinal motility after neuromuscular blockade reversal with sugammadex versus neostigmine\/glycopyrrolate in colorectal surgery patients","volume":"54","author":"Hunt","year":"2020","journal-title":"Ann Pharmacother"},{"issue":"5","key":"2026021918514131300_zxaf213-B43","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1177\/00031348211058631","article-title":"Effects of reversal technique for neuromuscular paralysis on time to recovery of bowel function after craniotomy","volume":"89","author":"Deljou","year":"2023","journal-title":"Am Surg"},{"key":"2026021918514131300_zxaf213-B44","doi-asserted-by":"publisher","first-page":"100233","DOI":"10.1016\/j.sipas.2023.100233","article-title":"A retrospective cohort study of the effect of sugammadex versus neostigmine on postoperative gastrointestinal motility in open colorectal surgical procedures","volume":"16","author":"Harris","year":"2024","journal-title":"Surg Pract Sci"},{"key":"2026021918514131300_zxaf213-B45","doi-asserted-by":"publisher","first-page":"111588","DOI":"10.1016\/j.jclinane.2024.111588","article-title":"Effects of neuromuscular block reversal with neostigmine\/glycopyrrolate versus sugammadex on bowel motility recovery after laparoscopic colorectal surgery: a randomized controlled trial","volume":"98","author":"Choi","year":"2024","journal-title":"J Clin Anesth"},{"issue":"2","key":"2026021918514131300_zxaf213-B46","first-page":"48","article-title":"Avoiding postoperative residual weakness\u2014a cornerstone of any ERAS protocol","volume":"34","author":"Renew","year":"2019","journal-title":"APSF Newsl"},{"issue":"3","key":"2026021918514131300_zxaf213-B47","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/aas.12651","article-title":"Enhanced recovery after surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for anaesthesia practice","volume":"60","author":"Feldheiser","year":"2016","journal-title":"Acta Anaesthesiol Scand"},{"key":"2026021918514131300_zxaf213-B48","doi-asserted-by":"publisher","first-page":"111357","DOI":"10.1016\/j.jclinane.2023.111357","article-title":"Moving perioperative care forward while reversing: is there hidden benefit to neuromuscular blockade antagonism with sugammadex?","volume":"96","author":"Renew","year":"2024","journal-title":"J Clin Anesth"},{"key":"2026021918514131300_zxaf213-B49","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.jclinane.2019.02.014","article-title":"Influence of reversal of neuromuscular blockade with sugammadex or neostigmine on postoperative quality of recovery following a single bolus dose of rocuronium: a prospective, randomized, double-blinded, controlled study","volume":"57","author":"Kim","year":"2019","journal-title":"J Clin Anesth"},{"issue":"9","key":"2026021918514131300_zxaf213-B50","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1111\/aas.12389","article-title":"Neostigmine vs. sugammadex: observational cohort study comparing the quality of recovery using the Postoperative Quality Recovery Scale","volume":"58","author":"Amorim","year":"2014","journal-title":"Acta Anaesthesiol Scand"},{"issue":"5","key":"2026021918514131300_zxaf213-B51","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1097\/ALN.0b013e3182342840","article-title":"Intraoperative acceleromyography monitoring reduces symptoms of muscle weakness and improves quality of recovery in the early postoperative period","volume":"115","author":"Murphy","year":"2011","journal-title":"Anesthesiology"},{"issue":"9","key":"2026021918514131300_zxaf213-B52","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1034\/j.1399-6576.2003.00226.x","article-title":"Drugs of anesthesia, central nicotinic receptors and post-operative cognitive dysfunction","volume":"47","author":"Fodale","year":"2003","journal-title":"Acta Anaesthesiol Scand"},{"issue":"4","key":"2026021918514131300_zxaf213-B53","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.bjane.2014.10.003","article-title":"The effect of sugammadex on postoperative cognitive function and recovery","volume":"66","author":"Pi\u015fkin","year":"2016","journal-title":"Braz J Anesthesiol Elsevier"},{"issue":"5","key":"2026021918514131300_zxaf213-B54","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1177\/0310057X1704500508","article-title":"Effect of sugammadex versus neostigmine\/atropine combination on postoperative cognitive dysfunction after elective surgery","volume":"45","author":"Batistaki","year":"2017","journal-title":"Anaesth Intensive Care"},{"issue":"1","key":"2026021918514131300_zxaf213-B55","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1213\/ane.0b013e3181ac53c3","article-title":"Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine: a multicenter, randomized, controlled trial","volume":"110","author":"Khuenl-Brady","year":"2010","journal-title":"Anesth Analg"},{"key":"2026021918514131300_zxaf213-B56","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jclinane.2017.03.004","article-title":"Role of sugammadex in accelerating postoperative discharge: a meta-analysis","volume":"39","author":"Carron","year":"2017","journal-title":"J Clin Anesth"},{"issue":"19","key":"2026021918514131300_zxaf213-B57","doi-asserted-by":"publisher","first-page":"e575","DOI":"10.1093\/ajhp\/zxae124","article-title":"The impact of sugammadex dosing and administration practices on potential cost savings for pharmacy departments","volume":"81","author":"Linn","year":"2024","journal-title":"Am J Health-Syst Pharm"},{"issue":"6","key":"2026021918514131300_zxaf213-B58","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1093\/bja\/aer142","article-title":"Sugammadex administration results in arousal from intravenous anaesthesia: a clinical and electroencephalographic observation","volume":"106","author":"Chazot","year":"2011","journal-title":"Br J Anaesth"},{"issue":"5","key":"2026021918514131300_zxaf213-B59","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s10877-010-9257-x","article-title":"Reversal of neuromuscular blockade by sugammadex does not affect EEG derived indices of depth of anesthesia","volume":"24","author":"Illman","year":"2010","journal-title":"J Clin Monit Comput"},{"issue":"2","key":"2026021918514131300_zxaf213-B60","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s10877-016-9844-6","article-title":"Sugammadex at both high and low doses does not affect the depth of anesthesia or hemodynamics: a randomized double blind trial","volume":"31","author":"Fassoulaki","year":"2017","journal-title":"J Clin Monit Comput"},{"key":"2026021918514131300_zxaf213-B61","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1016\/j.bja.2024.07.042","article-title":"Sugammadex hypersensitivity: a multicentre retrospective analysis of a large Australian cohort","volume":"14","author":"Crimmins","journal-title":"Br J Anaesth."},{"issue":"1","key":"2026021918514131300_zxaf213-B62","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.bja.2018.02.036","article-title":"Severe bradycardia and asystole after sugammadex","volume":"121","author":"Bhavani","year":"2018","journal-title":"Br J Anaesth"},{"issue":"2","key":"2026021918514131300_zxaf213-B63","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/anae.15902","article-title":"A prospective observational study of the effects of sugammadex on peri-operative oestrogen and progesterone levels in women who take hormonal contraception","volume":"78","author":"Devoy","year":"2023","journal-title":"Anaesthesia"},{"issue":"5","key":"2026021918514131300_zxaf213-B64","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1213\/ANE.0000000000005842","article-title":"Sugammadex versus neostigmine for reversal of residual neuromuscular blocks after surgery: a retrospective cohort analysis of postoperative side effects","volume":"134","author":"Ruetzler","year":"2022","journal-title":"Anesth Analg"}],"container-title":["American Journal of Health-System Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajhp\/advance-article-pdf\/doi\/10.1093\/ajhp\/zxaf213\/64079441\/zxaf213.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajhp\/article-pdf\/83\/5\/e183\/64079441\/zxaf213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajhp\/article-pdf\/83\/5\/e183\/64079441\/zxaf213.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:51:48Z","timestamp":1771545108000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajhp\/article\/83\/5\/e183\/8237532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,18]]},"references-count":64,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,8,18]]},"published-print":{"date-parts":[[2026,2,20]]}},"URL":"https:\/\/doi.org\/10.1093\/ajhp\/zxaf213","relation":{},"ISSN":["1079-2082","1535-2900"],"issn-type":[{"value":"1079-2082","type":"print"},{"value":"1535-2900","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3,1]]},"published":{"date-parts":[[2025,8,18]]}}}