{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:07:18Z","timestamp":1769576838349,"version":"3.49.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this case report is to highlight an unusual presentation of rifampin-induced bullous pemphigoid in a 37-year-old female undergoing tuberculosis treatment. The report aims to explore the challenges of managing drug-induced bullous pemphigoid while maintaining effective treatment for tuberculosis, emphasizing the necessity of a strategic approach to drug management and disease control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>A 37-year-old female with tuberculosis developed an atypical form of bullous pemphigoid during rifampin therapy. The patient presented with painful, pruritic vesicular lesions that directly manifested as bullous lesions without the typical prodromal phase and without mucosal involvement. Histopathological examination confirmed the diagnosis with subepidermal blisters and eosinophilic infiltration. Management of this case involved carefully balancing tuberculosis treatment with bullous pemphigoid control, which required a modified rechallenge protocol, dose titration of rifampin, and a combination of systemic corticosteroids, immunomodulators, and supportive care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case underscores the complexity of managing drug-induced bullous pemphigoid in patients undergoing treatment for tuberculosis. The successful outcome was achieved through a cautious approach, including a rechallenge protocol and careful drug dose adjustments. The case offers valuable insights for clinicians managing similar complex presentations of drug-induced bullous pemphigoid, demonstrating that, with a tailored treatment strategy, both conditions can be effectively controlled.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajhp\/zxaf218","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T11:51:10Z","timestamp":1755258670000},"page":"e99-e104","source":"Crossref","is-referenced-by-count":0,"title":["Rifampin-induced bullous pemphigoid in tuberculosis treatment: A strategic rechallenge approach"],"prefix":"10.1093","volume":"83","author":[{"given":"Vaishnavi V","family":"Gaonkar","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, KLE College of Pharmacy, KAHER , Belagavi, Karnataka ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay V","family":"Shanbhag","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, KLE College of Pharmacy, KAHER , Belagavi, Karnataka ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandati Santhosh","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, KLE College of Pharmacy, KAHER , Belagavi, Karnataka ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratiksha","family":"Kini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, KLE College of Pharmacy, KAHER , Belagavi, Karnataka ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavana","family":"Doshi","sequence":"additional","affiliation":[{"name":"HOD, Department of Dermatology, J N Medical College, KAHER , Belagavi, Karnataka ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"issue":"4","key":"2026012711372394600_zxaf218-B1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.4103\/jiaomr.jiaomr_126_18","article-title":"Drug-induced bullous pemphigoid\u2014a case report with review","volume":"30","author":"Rawson","year":"2018","journal-title":"J Indian Acad Oral Med Radiol"},{"issue":"15","key":"2026012711372394600_zxaf218-B2","doi-asserted-by":"crossref","first-page":"adv00224","DOI":"10.2340\/00015555-3457","article-title":"A systematic review of drug-induced pemphigoid","volume":"100","author":"Verheyden","year":"2020","journal-title":"Acta Derm Venereol"},{"issue":"2","key":"2026012711372394600_zxaf218-B3","first-page":"300","article-title":"Drug-induced bullous pemphigoid: rapid resolution with corticosteroid therapy","volume":"7","author":"Yulianggoro","year":"2024","journal-title":"J Med Chem Sci"},{"issue":"5","key":"2026012711372394600_zxaf218-B4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-4362.1991.tb03867.x","article-title":"Pemphigus and bullous pemphigoid due to drugs","volume":"30","author":"Ruocco","year":"1991","journal-title":"Int J Dermatol"},{"issue":"2","key":"2026012711372394600_zxaf218-B5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1001\/archderm.1970.04000080077015","article-title":"Bullous pemphigoid in an 11-year-old boy","volume":"102","author":"Bean","year":"1970","journal-title":"Arch Dermatol"},{"issue":"5","key":"2026012711372394600_zxaf218-B6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1365-4632.2009.04417.x","article-title":"Amlodipine-associated bullous pemphigoid with erythema multiforme-like clinical features","volume":"50","author":"Park","year":"2011","journal-title":"Int J Dermatol"},{"issue":"6","key":"2026012711372394600_zxaf218-B7","first-page":"562","article-title":"Furosemide-induced bullous pemphigoid: case report and review of literature","volume":"5","author":"Lee","year":"2","journal-title":"J Drugs Dermatol"},{"issue":"9","key":"2026012711372394600_zxaf218-B8","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1001\/archderm.1984.01650450078023","article-title":"Bullous pemphigoid-like lesions induced by phenacetin. 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