{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:00:55Z","timestamp":1780117255284,"version":"3.54.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Previous studies have shown decreased exposure to QTc-prolonging medications through utilization of a clinical decision support (CDS) alert in the electronic health record (EHR) in hospitalized patients. Minimization of risk factors, including exposure to QTc-prolonging medications, is important to decrease the risk of adverse outcomes, including ventricular arrhythmias. This study evaluated the effect of a patient-specific prolonged QTc EHR alert in nonhospitalized patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single-center, retrospective, quasi-experimental pre-post analysis of an interruptive alert that is triggered in adult nonhospitalized patients upon entry of an order for a QTc-prolonging medication for patients with the following QTc criteria: (1) QTc of \u2265500\u2005ms or QTc of &amp;lt;550\u2005ms with QRS of \u2264130\u2005ms without bundle branch block and not atrio-ventricular dual or ventricular paced or (2) QTc of &amp;gt;550\u2005ms. Pre- and post-alert groups were compared for the primary outcome of the number of QTc-prolonging medication orders entered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The alert significantly decreased the number of orders for QTc-prolonging medications (odds ratio, 0.0017; 95% confidence interval, 0.0001-0.0281; P &amp;lt; 0.001). The alert override rate was 50%. No patients in either group had documentation of torsades de pointes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrated that an interruptive EHR alert at the time of order entry can decrease exposure to QTc-prolonging medications and potentially decrease the risk for ventricular arrhythmias in nonhospitalized patients with a prolonged QTc interval. Further research is needed to determine whether integration of other patient-specific parameters into the CDS alert would improve its potential to lower the risk of QTc-related adverse outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajhp\/zxaf283","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T11:46:06Z","timestamp":1760787966000},"page":"e261-e268","source":"Crossref","is-referenced-by-count":0,"title":["Effect of a patient-specific QTc alert on decreasing prescribing of QTc-prolonging medications in outpatients"],"prefix":"10.1093","volume":"83","author":[{"given":"Christopher R","family":"Zimmerman","sequence":"first","affiliation":[{"name":"Health Information and Technology Services, Michigan Medicine , Ann Arbor, MI , , Ann Arbor, MI ,","place":["USA"]},{"name":"and Department of Pharmacy, University of Michigan , Ann Arbor, MI , , Ann Arbor, MI 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