{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:02:14Z","timestamp":1788300134020,"version":"build-2803163510"},"reference-count":14,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Data describing the impact of pharmacists on early sepsis management performed by multidisciplinary sepsis response teams are limited to the emergency department and lack contemporaneous comparator groups. Objectives of the study reported here included determining if pharmacist presence on a sepsis response team improves sepsis bundle compliance and outcomes of hospitalized patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single-center, retrospective cohort study of hospitalized adult patients diagnosed with severe sepsis or septic shock seen by a sepsis response team between July 2019 and July 2022. Patients were divided into 2 groups based on the presence (pharmacist present [PhP]) or absence (no pharmacist present [NPh]) of a pharmacist as a member of the sepsis response team. The primary endpoint was 1-hour bundle compliance, as defined by the Surviving Sepsis Campaign, with time zero defined as the time an alert was paged to the responding team. Secondary endpoints included rates of compliance with the Centers for Medicare and Medicaid Services 3- and 6-hour severe sepsis and septic shock (SEP-1) bundles, time to individual bundle component completion, hospital length of stay (LOS), and in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 167 responses were included (91 in the PhP group and 76 in the NPh group). A pharmacist\u2019s presence resulted in improved 1-hour bundle compliance (60.4% vs 44.7%, P = 0.045), an increased rate of antibiotic administration within 1\u2005hour of an sepsis alert page (84.6% vs 59.2%, P &amp;lt; 0.001), and a lower median time to antibiotic administration (51\u2005minutes vs 108\u2005minutes, P &amp;lt; 0.01). Rates of 3- and 6-hour bundle compliance, hospital LOS, and mortality were similar between the PhP and NPh groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pharmacist involvement in a sepsis response team is associated with improved completion of the 1-hour bundle, specifically the early administration of broad-spectrum antibiotics. Early identification of sepsis and alerting a multidisciplinary team remain barriers to optimizing treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajhp\/zxag195","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:42:49Z","timestamp":1782862969000},"source":"Crossref","is-referenced-by-count":1,"title":["Impact of pharmacist involvement on hospital sepsis response teams"],"prefix":"10.1093","author":[{"given":"Denis","family":"Vanini","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Utah Hospital , Salt Lake City, UT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Reid","sequence":"additional","affiliation":[{"name":"MedStar Georgetown University Hospital , Washington, DC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson","family":"Pero","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center , Rochester, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Rappaport","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center , Rochester, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M","family":"Groth","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center , Rochester, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"issue":"8","key":"2026072114163823900_zxag195-B1","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1007\/s00134-020-06151-x","article-title":"Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis","volume":"46","author":"Fleischmann-Struzek","year":"2020","journal-title":"Intensive Care Med"},{"issue":"11","key":"2026072114163823900_zxag195-B2","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med"},{"issue":"2","key":"2026072114163823900_zxag195-B3","doi-asserted-by":"publisher","first-page":"e0263936","DOI":"10.1371\/journal.pone.0263936","article-title":"Hour-1 bundle adherence was associated with reduction of in-hospital mortality among patients with sepsis in Japan","volume":"17","author":"Umemura","year":"2022","journal-title":"PLoS One"},{"issue":"9","key":"2026072114163823900_zxag195-B4","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1007\/s00134-015-3906-y","article-title":"The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study)","volume":"41","author":"Rhodes","year":"2015","journal-title":"Intensive Care Med"},{"issue":"8","key":"2026072114163823900_zxag195-B5","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1097\/ccm.0000000000003613","article-title":"National performance on the Medicare SEP-1 sepsis quality measure","volume":"47","author":"Barbash","year":"2019","journal-title":"Crit Care Med"},{"issue":"1","key":"2026072114163823900_zxag195-B6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13613-017-0280-7","article-title":"The impact of a multifaceted intervention including sepsis electronic alert system and sepsis response team on the outcomes of patients with sepsis and septic shock","volume":"7","author":"Arabi","year":"2017","journal-title":"Ann Intensive Care"},{"issue":"5","key":"2026072114163823900_zxag195-B7","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1177\/1062860616676887","article-title":"Sepsis and shock response team: impact of a multidisciplinary approach to implementing Surviving Sepsis Campaign guidelines and surviving the process","volume":"32","author":"Grek","year":"2017","journal-title":"Am J Med Qual"},{"issue":"3","key":"2026072114163823900_zxag195-B8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2146\/ajhp150186","article-title":"Pharmacist involvement in a multidisciplinary initiative to reduce sepsis-related mortality","volume":"73","author":"Beardsley","year":"2016","journal-title":"Am J Health-Syst Pharm"},{"issue":"9","key":"2026072114163823900_zxag195-B9","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1177\/1060028014538773","article-title":"Utilization of pharmacist responders as a component of a multidisciplinary sepsis bundle","volume":"48","author":"Flynn","year":"2014","journal-title":"Ann Pharmacother"},{"issue":"4","key":"2026072114163823900_zxag195-B10","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.ajem.2018.08.009","article-title":"Pharmacist impact on sepsis bundle compliance through participation on an emergency department sepsis alert team","volume":"37","author":"Yarbrough","year":"2019","journal-title":"Am J Emerg Med"},{"key":"2026072114163823900_zxag195-B11","doi-asserted-by":"publisher","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J Biomed Inform"},{"issue":"2","key":"2026072114163823900_zxag195-B12","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2013a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"issue":"1","key":"2026072114163823900_zxag195-B13","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1515\/dx-2019-0104","article-title":"Rate of diagnostic errors and serious misdiagnosis-related harms for major vascular events, infections, and cancers: toward a national incidence estimate using the \u201cBig Three\u201d","volume":"8","author":"Newman-Toker","year":"2020","journal-title":"Diagnosis (Berl)"},{"key":"2026072114163823900_zxag195-B14","article-title":"Sepsis Bundle Project (SEP) national hospital inpatient quality measures","author":"Sepsis Coordinator Network"}],"container-title":["American Journal of Health-System Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajhp\/advance-article-pdf\/doi\/10.1093\/ajhp\/zxag195\/68695674\/zxag195.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajhp\/advance-article-pdf\/doi\/10.1093\/ajhp\/zxag195\/68695674\/zxag195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:16:42Z","timestamp":1784657802000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajhp\/advance-article\/doi\/10.1093\/ajhp\/zxag195\/8724715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":14,"URL":"https:\/\/doi.org\/10.1093\/ajhp\/zxag195","relation":{},"ISSN":["1079-2082","1535-2900"],"issn-type":[{"value":"1079-2082","type":"print"},{"value":"1535-2900","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]},"article-number":"zxag195"}}