{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:54:46Z","timestamp":1791060886381,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Dementia with Lewy bodies (DLB) ranks among the most frequent neurodegenerative cognitive disorders, characterized by multi-domain deficits including autonomic dysfunction and fluctuating cognition. Current management remains symptomatic, particularly in patients with comorbidities limiting standard therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>We report a 73-year-old female with DLB and pre-existing cardiac conduction defects, rendering cholinesterase inhibitors contraindicated. Following memantine (10 mg\/day) treatment over three months, changes in autonomic and cognitive measures were observed. Heart rate variability parameters increased, accompanied by a reduction in SCOPA-AUT score and an increase in MMSE score. No adverse events were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest memantine as a potential therapeutic alternative for DLB patients with autonomic fragility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajhp\/zxag320","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:56:29Z","timestamp":1790855789000},"source":"Crossref","is-referenced-by-count":0,"title":["Improvement of Autonomic and Cognitive Dysfunction by Memantine in a Patient with Dementia with Lewy Bodies and Cardiac Conduction Defect: A Case Report"],"prefix":"10.1093","author":[{"given":"Chih-Chung","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, National Defense Medical University , Taipei ,","place":["Taiwan"]},{"name":"Department of Psychiatry, School of Medicine, College of Medicine, National Defense Medical University , Taipei ,","place":["Taiwan"]},{"name":"Hualien Armed Forces General Hospital , Hualien County ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Chih","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, National Defense Medical University , Taipei ,","place":["Taiwan"]},{"name":"Department of Psychiatry, School of Medicine, College of Medicine, National Defense Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Lun","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences, National Defense Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Wen","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, National Defense Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, National Defense Medical University , Taipei ,","place":["Taiwan"]},{"name":"Department of Psychiatry, School of Medicine, College of Medicine, National Defense Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Chang","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, National Defense Medical University , Taipei ,","place":["Taiwan"]},{"name":"Department of Psychiatry, School of Medicine, College of Medicine, National Defense Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-6206","authenticated-orcid":false,"given":"Yi-Wei","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, National Defense Medical University , Taipei ,","place":["Taiwan"]},{"name":"Department of Psychiatry, School of Medicine, College of Medicine, National Defense Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,3]]},"container-title":["American Journal of Health-System Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajhp\/advance-article-pdf\/doi\/10.1093\/ajhp\/zxag320\/71577465\/zxag320.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajhp\/advance-article-pdf\/doi\/10.1093\/ajhp\/zxag320\/71577465\/zxag320.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:21:49Z","timestamp":1791058909000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajhp\/advance-article\/doi\/10.1093\/ajhp\/zxag320\/8860338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ajhp\/zxag320","relation":{},"ISSN":["1079-2082","1535-2900"],"issn-type":[{"value":"1079-2082","type":"print"},{"value":"1535-2900","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,3]]},"article-number":"zxag320"}}