{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:24:49Z","timestamp":1759937089959},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T00:00:00Z","timestamp":1547856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>A case of alteplase administration to a patient with vasculitis and acute ischemic stroke (AIS) is reported.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>A 38-year-old woman with a recent diagnosis of granulomatosis with polyangiitis (GPA) received alteplase for AIS and developed symptomatic hemorrhagic conversion. Published reports regarding the safety of thrombolytic therapy in patients with a high inflammatory burden are inconsistent. The current case adds to the literature on the topic.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>More data regarding alteplase treatment in patients with GPA are needed to further establish the safety of this therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajhp\/zxy048","type":"journal-article","created":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T15:38:26Z","timestamp":1547912306000},"page":"211-213","source":"Crossref","is-referenced-by-count":2,"title":["Hemorrhagic conversion after alteplase administration in a patient with vasculitis and acute ischemic stroke"],"prefix":"10.1093","volume":"76","author":[{"given":"Brian W","family":"Gilbert","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Wesley Medical Center, Wichita, KS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laxmi","family":"Dhakal","sequence":"additional","affiliation":[{"name":"Neurocritical Care, Wesley Medical Center, Wichita, KS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Lacy","sequence":"additional","affiliation":[{"name":"Neurocritical Care, Wesley Medical Center, Wichita, KS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel B","family":"Huffman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Wesley Medical Center, Wichita, KS"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,1,19]]},"reference":[{"key":"2020071622255970500_CIT0001","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.09.004","article-title":"Lateral medullary stroke in patient with granulomatous 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