{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:13:00Z","timestamp":1787008380563,"version":"build-2736575974"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T00:00:00Z","timestamp":1560556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>A case report of the use of linezolid and daptomycin for the treatment of multidrug-resistant right-sided infective endocarditis is presented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>A 36-year-old patient with a history of intravenous drug use was hospitalized for treatment of native tricuspid valve endocarditis resulting in persistent methicillin-resistant Staphylococcus aureus bacteremia. During the admission the patient was unsuccessfully treated with vancomycin monotherapy (final E-test minimum inhibitory concentration, 4 \u03bcg\/mL). The patient\u2019s treatment was switched to daptomycin and gentamicin, with no improvement in blood culture results over 4 days. Gentamicin was discontinued, and linezolid was administered in combination with daptomycin; bacteremia was cleared after 13 days of linezolid and daptomycin combination therapy. Due to daptomycin resistance (minimum inhibitory concentration, 4 \u03bcg\/mL), gentamicin was substituted for daptomycin due to the former agent\u2019s synergistic effects with linezolid. After 23 days of therapy the patient was transferred to another facility for a tricuspid valve replacement procedure, which was completed without complications. The patient was transferred in stable condition to a skilled nursing facility to continue antibiotic therapy lasting 6 weeks from the date of surgery. The patient\u2019s blood cultures remained negative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A 36-year-old woman with resistant tricuspid valve endocarditis was successfully treated with linezolid in combination with daptomycin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajhp\/zxz101","type":"journal-article","created":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T12:09:52Z","timestamp":1560600592000},"page":"1033-1036","source":"Crossref","is-referenced-by-count":10,"title":["Treatment of tricuspid valve endocarditis with daptomycin and linezolid therapy"],"prefix":"10.1093","volume":"76","author":[{"given":"Kayla M","family":"Galanter","sequence":"first","affiliation":[{"name":"College of Pharmacy, Western University, Pomona, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Ho","sequence":"additional","affiliation":[{"name":"Pharmacy, San Leandro Hospital, San Leandro, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,15]]},"reference":[{"key":"2019070204524192600_CIT0001","doi-asserted-by":"crossref","first-page":"255","DOI":"10.21037\/acs.2017.03.09","article-title":"Tricuspid valve endocarditis","volume":"6","author":"Hussain","year":"2017","journal-title":"Ann Cardiothorac Surg."},{"key":"2019070204524192600_CIT0002","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/1995-705X.76805","article-title":"Tricuspid valve endocarditis in an intravenous drug abuser masquerading as pulmonary tuberculosis","volume":"11","author":"Panduranga","year":"2010","journal-title":"Heart Views."},{"key":"2019070204524192600_CIT0003","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1161\/CIR.0000000000000296","article-title":"Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications: a scientific statement for healthcare professionals from the American Heart Association","volume":"132","author":"Baddour","year":"2015","journal-title":"Circulation."},{"key":"2019070204524192600_CIT0004","article-title":"Early oral switch to linezolid for low-risk patients with Staphylococcus aureus bloodstream infections: a propensity-matched cohort study","author":"Willekens","journal-title":"Clin Infect Dis"},{"key":"2019070204524192600_CIT0005","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1086\/381972","article-title":"Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of gram-positive bacterial infections","volume":"38","author":"Pankey","year":"2004","journal-title":"Clin 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