{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:45:44Z","timestamp":1787665544972,"version":"build-2736575974"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Casey Lee Ball Foundation"},{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["1R18HS023763-01"],"award-info":[{"award-number":["1R18HS023763-01"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>Medications are commonly associated with acute kidney injury (AKI). However, in both clinical practice and research, consideration of specific medications as nephrotoxic varies widely. The Nephrotoxic Injury Negated by Just-in-time Action quality improvement collaborative was formed to focus on prevention or reduction of nephrotoxic medication-associated AKI in noncritically ill hospitalized children. However, there were discrepancies among institutions as to which medications should be considered nephrotoxic. The collaborative convened a Nephrotoxic Medication (NTMx) Subcommittee to develop a consensus for the classification of nephrotoxic medications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>The NTMx Subcommittee initially included pediatric nephrologists, a pharmacist, and a pediatric intensivist. The committee reviewed NTMx lists from the collaborative and identified changes from the initial NTMx list. The NTMx Subcommittee conducted a literature review of the disputed medications and assigned an evidence grade based on the reported association with nephrotoxicity and the quality of the data. The association between medication exposure and AKI was also determined using administrative data from the Pediatric Health Information Systems database. The NTMx Subcommittee then came to a majority consensus regarding which medications should be included on the list. The subcommittee\u2019s recommendations were presented to the larger collaborative for approval, and consensus was achieved. The list continues to be reviewed and updated annually.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Formation of a multicenter quality-improvement initiative exposed current limitations as to which medications are considered nephrotoxic in clinical and research settings and presented an opportunity to approach this problem using an evidence-based process. A consensus definition of nephrotoxic-medication exposure was achieved.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajhp\/zxz203","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T19:16:37Z","timestamp":1572462997000},"page":"1869-1874","source":"Crossref","is-referenced-by-count":33,"title":["Evidence-based development of a nephrotoxic medication list to screen for acute kidney injury risk in hospitalized children"],"prefix":"10.1093","volume":"76","author":[{"given":"Elizabeth","family":"Goswami","sequence":"first","affiliation":[{"name":"Department of Pharmacy, the Johns Hopkins Hospital, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K","family":"Ogden","sequence":"first","affiliation":[{"name":"Pharmacy Department, Children\u2019s Mercy Hospital and Clinics, Kansas City, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"William E","family":"Bennett","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric and Adolescent Comparative Effectiveness Research, Indiana University School of Medicine, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L","family":"Goldstein","sequence":"first","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hackbarth","sequence":"first","affiliation":[{"name":"Helen DeVos Children\u2019s Hospital, Grand Rapids, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J G","family":"Somers","sequence":"first","affiliation":[{"name":"Boston Children\u2019s Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karyn","family":"Yonekawa","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Nephrology, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Misurac","sequence":"first","affiliation":[{"name":"University of Iowa Stead Family Children\u2019s Hospital, Iowa City, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"2020042019455876400_CIT0001","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00467-016-3446-x","article-title":"Drug-associated acute kidney injury: who\u2019s at risk?","volume":"32","author":"Joyce","year":"2017","journal-title":"Pediatr Nephrol."},{"key":"2020042019455876400_CIT0002","doi-asserted-by":"crossref","first-page":"e391","DOI":"10.1097\/PCC.0000000000000859","article-title":"Risk factors of acute kidney injury in critically ill children","volume":"17","author":"Slater","year":"2016","journal-title":"Pediatr Crit Care Med."},{"key":"2020042019455876400_CIT0003","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1053\/j.ajkd.2004.09.028","article-title":"Pediatric ARF epidemiology at a tertiary care center from 1999 to 2001","volume":"45","author":"Hui-Stickle","year":"2005","journal-title":"Am J Kidney Dis."},{"key":"2020042019455876400_CIT0004","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1053\/j.ajkd.2015.07.019","article-title":"Acute kidney injury incidence in noncritically ill hospitalized children, adolescents, and young adults: a retrospective observational study","volume":"67","author":"McGregor","year":"2016","journal-title":"Am J Kidney Dis."},{"key":"2020042019455876400_CIT0005","doi-asserted-by":"crossref","first-page":"856","DOI":"10.2215\/CJN.08110910","article-title":"Acute kidney injury and increasing nephrotoxic-medication exposure in noncritically-ill children","volume":"6","author":"Moffett","year":"2011","journal-title":"Clin J Am Soc Nephrol."},{"key":"2020042019455876400_CIT0006","doi-asserted-by":"crossref","first-page":"e756","DOI":"10.1542\/peds.2013-0794","article-title":"Electronic health record identification of nephrotoxin exposure and associated acute kidney injury","volume":"132","author":"Goldstein","year":"2013","journal-title":"Pediatrics."},{"key":"2020042019455876400_CIT0007","first-page":"1","article-title":"KDIGO clinical practice guideline for acute kidney injury","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"2020042019455876400_CIT0008","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.kint.2016.03.031","article-title":"A sustained quality improvement program reduces nephrotoxic medication-associated acute kidney injury","volume":"90","author":"Goldstein","year":"2016","journal-title":"Kidney Int."},{"key":"2020042019455876400_CIT0009","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ki.2015.115","article-title":"Phenotype standardization for drug-induced kidney disease","volume":"88","author":"Mehta","year":"2015","journal-title":"Kidney Int."},{"key":"2020042019455876400_CIT0010","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1007\/s00467-007-0721-x","article-title":"Nephrotoxicity as a cause of acute kidney injury in children","volume":"23","author":"Patzer","year":"2008","journal-title":"Pediatr Nephrol"},{"key":"2020042019455876400_CIT0011","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1611391","article-title":"Epidemiology of acute kidney injury in critically ill children and young adults","volume":"376","author":"Kaddourah","year":"2017","journal-title":"N Engl J Med."},{"key":"2020042019455876400_CIT0012","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1177\/1060028014549185","article-title":"Factors associated with acute kidney injury in children receiving vancomycin","volume":"48","author":"Sinclair","year":"2014","journal-title":"Ann Pharmacother."},{"key":"2020042019455876400_CIT0013","volume-title":"Drug information handbook","author":"Lacy","year":"2009"},{"key":"2020042019455876400_CIT0014","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ."},{"key":"2020042019455876400_CIT0015","volume-title":"PHIS","author":"Children\u2019s Hospital Association"}],"container-title":["American Journal of Health-System Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajhp\/article-pdf\/76\/22\/1869\/33106190\/zxz203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ajhp\/article-pdf\/76\/22\/1869\/33106190\/zxz203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T23:56:53Z","timestamp":1587427013000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajhp\/article\/76\/22\/1869\/5609603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,30]]},"references-count":15,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2019,10,30]]},"published-print":{"date-parts":[[2019,10,30]]}},"URL":"https:\/\/doi.org\/10.1093\/ajhp\/zxz203","relation":{},"ISSN":["1079-2082","1535-2900"],"issn-type":[{"value":"1079-2082","type":"print"},{"value":"1535-2900","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,11,15]]},"published":{"date-parts":[[2019,10,30]]}}}