{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:32:49Z","timestamp":1788478369842,"version":"build-2803163510"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Physiological studies showed benefits for bedside setting of personalized positive end-expiratory pressure (PEEP) by electrical impedance tomography (EIT), balancing lung overdistension and collapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate whether EIT-guided PEEP improves the clinical outcomes of patients with acute respiratory distress syndrome (ARDS) compared to the lower PEEP\/FiO2 table strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized trial enrolled adult patients with moderate to severe ARDS across five sites in China from February 2022 to June 2023. Participants were randomly assigned to EIT-guided PEEP (collapse-overdistension crossing point value by decremental PEEP trial) or the classical lower PEEP\/FiO2 table. The primary outcome was 28-day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>The trial was terminated early for futility, based on a pre-planned interim analysis. A total of 190 patients were included and completed follow-up. PEEP levels didn\u2019t differ between groups during the first seven days (difference in marginal means 0.2 [standard error 0.1]; p\u2009=\u20090.187). At 28 days, mortality was 52 patients (55.9%) in the EIT-guided PEEP group and 51 patients (52.6%) in the lower PEEP\/FiO2 table group (hazard ratio [HR] 0.96 [95% confidence interval (CI) 0.65-1.41]; p\u2009=\u20090.821). Ventilator-free days and other secondary clinical and safety outcomes did not differ, either. However, EIT-guided PEEP assigned higher PEEP and decreased mortality in patients with higher lung recruitability, as assessed by the recruitment-inflation ratio method (16 [35.6%] of 45 patients vs. 27 [60.0%] of 45 patients; HR 0.49 [95% CI 0.26-0.91]; p\u2009=\u20090.024).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with moderate to severe ARDS, EIT-guided PEEP did not significantly reduce 28-day mortality compared with the lower PEEP\/FiO2 table strategy. Due to early termination, the study may have been underpowered to detect a clinically important difference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>clinicaltrials.gov NCT05207202<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajrccm\/aamaf125","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T12:22:17Z","timestamp":1767615737000},"source":"Crossref","is-referenced-by-count":7,"title":["Electrical impedance tomography-guided PEEP and mortality of patients with the acute respiratory distress syndrome: The EITVent randomized clinical trial"],"prefix":"10.1093","author":[{"given":"Xueyan","family":"Yuan","sequence":"first","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Critical Care Medicine , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]},{"name":"Zhongda Hospital, School of Medicine, Southeast University , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital of Fudan University Department of Critical Care Medicine, , Shanghai, 200032, China; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, , Shanghai,","place":["China"]},{"name":"Fudan University Department of Critical Care Medicine, , Shanghai, 200032, China; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[{"name":"Renji Hospital, School of Medicine, Shanghai Jiao Tong University Department of Critical Care Medicine, , No. 160, Pujian Road, Pudong New District, Shanghai, 200120,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Sang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University , Department of Critical Care Medicine, , Guangzhou,","place":["China"]},{"name":"Guangzhou Medical University , Department of Critical Care Medicine, , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Huang","sequence":"additional","affiliation":[{"name":"Sichuan Academy of Medical Sciences and Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China Department of ICU, , Chengdu 610072,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Critical Care Medicine , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]},{"name":"Zhongda Hospital, School of Medicine, Southeast University , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Critical Care Medicine , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]},{"name":"Zhongda Hospital, School of Medicine, Southeast University , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Renji Hospital, School of Medicine, Shanghai Jiao Tong University Department of Critical Care Medicine, , No. 160, Pujian Road, Pudong New District, Shanghai, 200120,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxian","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital of Fudan University Department of Critical Care Medicine, , Shanghai, 200032, China; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, , Shanghai,","place":["China"]},{"name":"Fudan University Department of Critical Care Medicine, , Shanghai, 200032, China; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University , Department of Critical Care Medicine, , Guangzhou,","place":["China"]},{"name":"Guangzhou Medical University , Department of Critical Care Medicine, , Guangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Lu","sequence":"additional","affiliation":[{"name":"Sichuan Academy of Medical Sciences and Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China Department of ICU, , Chengdu 610072,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Southeast University School of Biological Science and Medical Engineering, , Nanjing 210096,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"University of York Center for Health Economics, , York, UK; , Liverpool School of Tropical Medicine, Liverpool,","place":["UK"]},{"name":"Global Health Trials Unit Center for Health Economics, , York, UK; , Liverpool School of Tropical Medicine, Liverpool,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanqi","family":"Guo","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Critical Care Medicine , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]},{"name":"Zhongda Hospital, School of Medicine, Southeast University , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Xie","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital of Fudan University Department of Critical Care Medicine, , Shanghai, 200032, China; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, , Shanghai,","place":["China"]},{"name":"Fudan University Department of Critical Care Medicine, , Shanghai, 200032, China; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University School of Biomedical Engineering, , China; Department of Critical Care Medicine, , China; Institute of Technical Medicine, , Villingen-Schwenningen,","place":["Germany"]},{"name":"Peking Union Medical College Hospital School of Biomedical Engineering, , China; Department of Critical Care Medicine, , China; Institute of Technical Medicine, , Villingen-Schwenningen,","place":["Germany"]},{"name":"Furtwangen University School of Biomedical Engineering, , China; Department of Critical Care Medicine, , China; Institute of Technical Medicine, , Villingen-Schwenningen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Huang","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Critical Care Medicine , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]},{"name":"Zhongda Hospital, School of Medicine, Southeast University , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Critical Care Medicine , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]},{"name":"Zhongda Hospital, School of Medicine, Southeast University , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Mauri","sequence":"additional","affiliation":[{"name":"Critical Care and Emergency, IRCCS (Institute for Treatment and Research) Ca\u2019 Granda Maggiore Policlinico Hospital Foundation Department of Anesthesia, , Via Sforza 35, 20122 Milan, Italy; Department of Pathophysiology and Transplantation, ,","place":["Italy"]},{"name":"University of Milan Department of Anesthesia, , Via Sforza 35, 20122 Milan, Italy; Department of Pathophysiology and Transplantation, ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Qiu","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Critical Care Medicine , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]},{"name":"Zhongda Hospital, School of Medicine, Southeast University , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Critical Care Medicine , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]},{"name":"Zhongda Hospital, School of Medicine, Southeast University , Department of Critical Care Medicine, , Nanjing, 210009,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Chi-ARDS Net (Chinese ARDS Research Network)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,23]]},"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article-pdf\/doi\/10.1093\/ajrccm\/aamaf125\/66518936\/aamaf125.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article-pdf\/doi\/10.1093\/ajrccm\/aamaf125\/66518936\/aamaf125.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:03:53Z","timestamp":1769159033000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article\/doi\/10.1093\/ajrccm\/aamaf125\/8435575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ajrccm\/aamaf125","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,23]]},"article-number":"aamaf125"}}