{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T02:56:55Z","timestamp":1781146615199,"version":"3.54.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Novartis Co. Ltd"},{"name":"EU\u2019s Innovative Medicines Initiative"},{"name":"National Natural Science Foundation\u2014Outstanding Youth Fund","award":["82222001"],"award-info":[{"award-number":["82222001"]}]},{"name":"Major Project of Guangzhou National Laboratory","award":["GZNL2024A02003"],"award-info":[{"award-number":["GZNL2024A02003"]}]},{"name":"Noncommunicable Chronic Diseases\u2014National Science and Technology Major Project","award":["2024ZD0529600"],"award-info":[{"award-number":["2024ZD0529600"]}]},{"DOI":"10.13039\/501100012245","name":"Guangdong Science and Technology Foundation","doi-asserted-by":"publisher","award":["2019B030316028"],"award-info":[{"award-number":["2019B030316028"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Guangdong Science and Technology Foundation","doi-asserted-by":"publisher","award":["2023B03J0407"],"award-info":[{"award-number":["2023B03J0407"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Guangdong Science and Technology Foundation","doi-asserted-by":"publisher","award":["2024A03J1206"],"award-info":[{"award-number":["2024A03J1206"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Guangdong Science and Technology Foundation","doi-asserted-by":"publisher","award":["2024A04J6495"],"award-info":[{"award-number":["2024A04J6495"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"DOI":"10.1093\/ajrccm\/aamag032","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:43:53Z","timestamp":1769777033000},"page":"1343-1346","source":"Crossref","is-referenced-by-count":0,"title":["The CFTR potentiator icenticaftor for treatment of bronchiectasis: an international phase 2, double-blind, randomized placebo-controlled trial"],"prefix":"10.1093","volume":"212","author":[{"given":"Wei-Jie","family":"Guan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Allergy and Clinical Immunology, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University , Guangzhou, P. R.","place":["China"]},{"name":"China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangdong Provincial Key Laboratory of Respiratory Disease Research, Guangzhou Medical University , Guangzhou, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S","family":"Haworth","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital NHS Foundation Trust and Department of Medicine, University of Cambridge , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm A W M","family":"Tiddens","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam , Rotterdam,","place":["The Netherlands"]},{"name":"Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC Sophia Children\u2019s Hospital, University Medical Center Rotterdam , Rotterdam,","place":["The Netherlands"]},{"name":"Thirona , Nijmegen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Loebinger","sequence":"additional","affiliation":[{"name":"Host Defence Unit, Royal Brompton Hospital , London,","place":["United Kingdom"]},{"name":"NHLI, Imperial College London , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam T","family":"Hill","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research Institute for Regeneration and Repair, The University of Edinburgh Edinburgh BioQuarter , Edinburgh,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Sibila","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias M.P. (CIBERES) , Barcelona,","place":["Spain"]},{"name":"Institut d\u2018Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Barcelona,","place":["Spain"]},{"name":"Respiratory Department, Hospital Cl\u00ednic, University of Barcelona , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix C","family":"Ringshausen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH) , Hannover,","place":["Germany"]},{"name":"German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hannover (BREATH) , Hannover,","place":["Germany"]},{"name":"European Reference Network on Rare and Complex Respiratory Diseases (ERN-LUNG) , Frankfurt,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget D","family":"Stuart","sequence":"additional","affiliation":[{"name":"Biomedical Research, Novartis , Cambridge, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Wang","sequence":"additional","affiliation":[{"name":"Analytics-EDA, Novartis , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Stuart","family":"Elborn","sequence":"additional","affiliation":[{"name":"Centre for Infection and Immunity, Queen\u2019s University Belfast , Belfast,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Shan","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Allergy and Clinical Immunology, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University , Guangzhou, P. R.","place":["China"]},{"name":"China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangdong Provincial Key Laboratory of Respiratory Disease Research, Guangzhou Medical University , Guangzhou, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D","family":"Chalmers","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine and Gastroenterology, University of Dundee , Dundee,","place":["United Kingdom"]},{"name":"John Radcliffe Hospital, University of Oxford , Oxford,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"2026061022133686900_aamag032-B1","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1038\/s41385-018-0013-8","article-title":"Increased intracellular Cl- concentration promotes ongoing inflammation in airway epithelium","volume":"11","author":"Zhang","year":"2018","journal-title":"Mucosal Immunol"},{"key":"2026061022133686900_aamag032-B2","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/S0140-6736(18)31767-7","article-title":"Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity","volume":"392","author":"Flume","year":"2018","journal-title":"Lancet"},{"key":"2026061022133686900_aamag032-B3","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/S2213-2600(20)30557-9","article-title":"The sputum microbiome and clinical outcomes in patients with bronchiectasis: a prospective observational study","volume":"9","author":"Dicker","year":"2021","journal-title":"Lancet Respir Med"},{"key":"2026061022133686900_aamag032-B4","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.jcf.2020.11.002","article-title":"Safety and efficacy of the cystic fibrosis transmembrane conductance regulator potentiator icenticaftor (QBW251)","volume":"20","author":"Kazani","year":"2021","journal-title":"J Cyst Fibros"},{"key":"2026061022133686900_aamag032-B5","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.2147\/COPD.S257474","article-title":"Efficacy and safety of the CFTR potentiator icenticaftor (QBW251) in COPD: results from a phase 2 randomized trial","volume":"15","author":"Rowe","year":"2020","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2026061022133686900_aamag032-B6","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1164\/rccm.202303-0458OC","article-title":"Icenticaftor, a CFTR potentiator, in COPD: a multicenter, parallel-group, double-blind clinical trial","volume":"208","author":"Martinez","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"2026061022133686900_aamag032-B7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.15326\/jcopdf.2.1.2014.0138","article-title":"Plasma fibrinogen as a biomarker for mortality and hospitalized exacerbations in people with COPD","volume":"2","author":"Mannino","year":"2015","journal-title":"Chronic Obstr Pulm Dis"},{"key":"2026061022133686900_aamag032-B8","doi-asserted-by":"publisher","first-page":"e002049","DOI":"10.1136\/bmjresp-2023-002049","article-title":"Considerations for the use of inhaled antibiotics for\u2002Pseudomonas aeruginosa\u2002in people with cystic fibrosis receiving CFTR modulator therapy","volume":"11","author":"Burgel","year":"2024","journal-title":"BMJ Open Respir Res"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article-pdf\/doi\/10.1093\/ajrccm\/aamag032\/66750444\/aamag032.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/6\/1343\/66750444\/aamag032.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/6\/1343\/66750444\/aamag032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T02:13:44Z","timestamp":1781144024000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/212\/6\/1343\/8460079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":8,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,2,4]]},"published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajrccm\/aamag032","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,2,4]]}}}