{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:45:52Z","timestamp":1792856752438,"version":"4.5.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031293","name":"PureTech Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031293","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Deupirfenidone is a strategically deuterated form of pirfenidone that retains pharmacodynamic activity but has a differentiated pharmacokinetic profile that may enable improved efficacy and favorable tolerability in patients with idiopathic pulmonary fibrosis (IPF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of deupirfenidone compared with placebo and pirfenidone in patients with IPF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were randomized 1:1:1:1 to deupirfenidone 550\u2009mg TID, deupirfenidone 825\u2009mg TID, pirfenidone 801\u2009mg TID, or placebo. The primary endpoint was the rate of change in forced vital capacity (FVC) for the combined arms of deupirfenidone versus placebo at 26\u2009weeks. The primary and secondary analyses used Bayesian and frequentist approaches, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>A total of 257 patients with IPF were randomized, and the proportion on treatment at the end of the study was 80.0%, 68.3%, 64.6%, and 78.1% for the placebo, pirfenidone, deupirfenidone 550\u2009mg, and deupirfenidone 825\u2009mg arms, respectively. Posterior mean change in FVC for placebo was -110.71\u2009mL (95% credible interval (CI), -148.75, -70.98), and for the combined deupirfenidone arms was -48.42\u2009mL (95% CI, -87.66, -9.04) with a posterior mean difference of 62.29\u2009mL (95% CI l, -6.13, 115.73; posterior probability, 0.985). Using a frequentist approach, the adjusted mean change in FVC for the placebo arm was -112.5\u2009mL (95% CI, -167.2, -57.8), and for the deupirfenidone 825\u2009mg arm was -21.5\u2009mL (95% CI, -78.2, 35.1); the adjusted mean difference was 91.0\u2009mL (95% CI, 12.2, 169.7; P\u2009=\u2009.02). The most common adverse events for each active treatment arm were gastrointestinal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with IPF, treatment with deupirfenidone slowed lung disease progression over 26\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Clinicaltrials.gov number NCT05321420.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajrccm\/aamag155","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:50:22Z","timestamp":1774615822000},"page":"1761-1769","source":"Crossref","is-referenced-by-count":4,"title":["Deupirfenidone compared with pirfenidone and placebo in idiopathic pulmonary fibrosis (ELEVATE-IPF): a phase 2b randomized placebo-controlled trial"],"prefix":"10.1093","volume":"212","author":[{"given":"Toby M","family":"Maher","sequence":"first","affiliation":[{"name":"Imperial College, National Heart and Lung Institute , London,","place":["United Kingdom"]},{"name":"Keck School of Medicine, University of Southern California , Los Angeles, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Hamblin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Kansas Medical Center , Kansas City, KS,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Il","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Myongji Hospital, Hanyang University , Goyang-si,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Hajari","family":"Case","sequence":"additional","affiliation":[{"name":"Department of 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