{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:01:31Z","timestamp":1785484891256,"version":"3.56.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dalian Medical Key Specialty Climbing the Peak Plan","award":["2022ZZ267"],"award-info":[{"award-number":["2022ZZ267"]}]},{"name":"Dalian High-Level Talents Innovation Support Plan","award":["2021RQ029"],"award-info":[{"award-number":["2021RQ029"]}]},{"name":"Dalian High-Level Talents Innovation Support Plan","award":["2023RY019"],"award-info":[{"award-number":["2023RY019"]}]},{"name":"Liaoning Province Science and Technology Plan Joint Program","award":["2024-MSLH-072"],"award-info":[{"award-number":["2024-MSLH-072"]}]},{"name":"Major Clinical Research Projects of Central Hospital of Dalian University of Technology","award":["2025ZXYYCR001"],"award-info":[{"award-number":["2025ZXYYCR001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"DOI":"10.1093\/ajrccm\/aamag235","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:41:58Z","timestamp":1778240518000},"page":"1845-1848","source":"Crossref","is-referenced-by-count":0,"title":["Olanzapine versus low-dose dexmedetomidine for delirium in patients with critical illness: a randomized clinical trial"],"prefix":"10.1093","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5922-8216","authenticated-orcid":false,"given":"Jinjie","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, Central Hospital of Dalian University of Technology , Dalian,","place":["China"]},{"name":"Faculty of Medicine, Dalian University of Technology , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3832-1271","authenticated-orcid":false,"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Central Hospital of Dalian University of Technology , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8380-4076","authenticated-orcid":false,"given":"Ximing","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocritical Care Unit, Beijing Tiantan Hospital, Capital Medical University , Beijing,","place":["China"]},{"name":"China National Clinical Research Center for Neurological Diseases , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5212-1088","authenticated-orcid":false,"given":"Rongli","family":"Yang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dalian University of Technology , Dalian,","place":["China"]},{"name":"Intensive Care Unit, Central Hospital of Dalian University of Technology , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4245-4014","authenticated-orcid":false,"given":"Mengxing","family":"Wang","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Diseases , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6086-4068","authenticated-orcid":false,"given":"Xiao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Central Hospital of Dalian University of Technology , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9592-1569","authenticated-orcid":false,"given":"Kai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Central Hospital of Dalian University of Technology , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0841-2600","authenticated-orcid":false,"given":"Guozhi","family":"Wu","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Central Hospital of Dalian University of Technology , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2009-5740","authenticated-orcid":false,"given":"Di","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dalian University of Technology , Dalian,","place":["China"]},{"name":"Department of Neurological Intervention and Intensive Care, Central Hospital of Dalian University of Technology , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5336-0200","authenticated-orcid":false,"given":"Sibo","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dalian University of Technology , Dalian,","place":["China"]},{"name":"Intensive Care Unit, Central Hospital of Dalian University of Technology , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"2026073103520384200_aamag235-B1","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1007\/s00134-025-08167-7","article-title":"Prevalence and incidence of ICU delirium and pain: a systematic review and meta-analysis","volume":"51","author":"Leong","year":"2025","journal-title":"Intensive Care Med"},{"key":"2026073103520384200_aamag235-B2","doi-asserted-by":"publisher","first-page":"e711","DOI":"10.1097\/CCM.0000000000006574","article-title":"A focused update to the clinical practice guidelines for the prevention and management of pain, anxiety, agitation\/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU","volume":"53","author":"Lewis","year":"2025","journal-title":"Crit Care Med"},{"key":"2026073103520384200_aamag235-B3","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1056\/NEJMoa1808217","article-title":"Haloperidol and ziprasidone for treatment of delirium in critical illness","volume":"379","author":"Girard","year":"2018","journal-title":"N Engl J Med"},{"key":"2026073103520384200_aamag235-B4","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.7326\/M22-3021","article-title":"Comparative safety analysis of oral antipsychotics for in-hospital adverse clinical events in older adults after major surgery: a nationwide cohort study","volume":"176","author":"Kim","year":"2023","journal-title":"Ann Intern Med"},{"key":"2026073103520384200_aamag235-B5","doi-asserted-by":"publisher","first-page":"111617","DOI":"10.1016\/j.biopha.2021.111617","article-title":"Are dexmedetomidine and olanzapine suitable to control delirium in critically ill elderly patients? A retrospective cohort study","volume":"139","author":"Liu","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"2026073103520384200_aamag235-B6","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1001\/jama.286.21.2703","article-title":"Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)","volume":"286","author":"Ely","year":"2001","journal-title":"JAMA"},{"key":"2026073103520384200_aamag235-B7","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1164\/rccm.201710-1995OC","article-title":"Low-dose nocturnal dexmedetomidine prevents ICU delirium. A randomized, placebo-controlled trial","volume":"197","author":"Skrobik","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2026073103520384200_aamag235-B8","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1164\/rccm.202206-1208OC","article-title":"Dexmedetomidine and propofol sedation in critically ill patients and dose-associated 90-day mortality: a secondary cohort analysis of a randomized controlled trial (SPICE III)","volume":"207","author":"Shehabi","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"2026073103520384200_aamag235-B9","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1164\/rccm.202002-0320OC","article-title":"Long-term outcomes in ICU patients with delirium: a population-based cohort study","volume":"204","author":"Fiest","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2026073103520384200_aamag235-B10","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00134-022-06712-2","article-title":"Dexmedetomidine vs other sedatives in critically ill mechanically ventilated adults: a systematic review and meta-analysis of randomized trials","volume":"48","author":"Lewis","year":"2022","journal-title":"Intensive Care Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article-pdf\/doi\/10.1093\/ajrccm\/aamag235\/68272979\/aamag235.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/8\/1845\/68272979\/aamag235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/8\/1845\/68272979\/aamag235.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:52:08Z","timestamp":1785484328000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/212\/8\/1845\/8676450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":10,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,5,12]]},"published-print":{"date-parts":[[2026,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajrccm\/aamag235","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,5,12]]}}}