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Identifying PVOD\/PCH early before therapy initiation could aid management and expedite transplant referral.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to develop a likelihood score distinguishing PVOD\/PCH from other forms of PAH using clinical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Due to low PVOD\/PCH prevalence and no dedicated registries, we leveraged published case-control\/case-series studies to assess the ability of several clinical variables to discriminate PVOD\/PCH from PAH. From pooled literature-derived data, we performed sensitivity\/specificity and simulation-based receiver operating characteristic (ROC) analyses to estimate variable performance. Top-performing variables formed a PVOD\/PCH likelihood score, which had its accuracy tested for distinguishing histopathology-confirmed PVOD\/PCH cases (n\u2009=\u200937) from PAH controls (n\u2009=\u200960) in 3 cohorts of transplant-eligible patients from the United States, Spain, and the Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>DLCO, 6-minute walk desaturation, PaO2, sex, smoking history, computed tomography (CT) septal line thickening, and CT lymphadenopathy had the highest sensitivity and specificity performance and were incorporated into the PVOD score. Across test cohorts, the score achieved a ROC area under the curve of 0.97 (95% CI, 0.93-1.00) for discriminating PVOD\/PCH and it retained accuracy when data were missing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This score could facilitate early PVOD\/PCH identification in incident PAH, potentially helping expedite transplant referral and informing therapy initiation\/titration decisions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajrccm\/aamag289","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:50:38Z","timestamp":1781092238000},"page":"2199-2210","source":"Crossref","is-referenced-by-count":1,"title":["Identification of pulmonary arterial hypertension patients with venous or capillary involvement"],"prefix":"10.1093","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-2344","authenticated-orcid":false,"given":"Adam M","family":"Andruska","sequence":"first","affiliation":[{"name":"Department of Medicine, Pulmonary, Allergy, and Critical Care, Stanford University , Stanford, CA,","place":["United States"]},{"name":"Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University , Stanford, CA,","place":["United States"]},{"name":"Cardiovascular Institute, Stanford University , Stanford, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-4037","authenticated-orcid":false,"given":"Alejandro","family":"Cruz-Utrilla","sequence":"additional","affiliation":[{"name":"Pulmonary Hypertension Unit, Department of Cardiology, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid , Madrid,","place":["Spain"]},{"name":"European Reference Network on Rare Respiratory Diseases (ERN-Lung) Pulmonary Hypertension Core Network, , Brussels,","place":["Belgium"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBER-CV) Cardiovascular Diseases Program, , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3854-4137","authenticated-orcid":false,"given":"Esther J","family":"Nossent","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Cardiovascular Sciences Research Institute , Amsterdam,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-7539","authenticated-orcid":false,"given":"Lucas R","family":"Celant","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Cardiovascular Sciences Research Institute , Amsterdam,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issac Yiqun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, University of Toronto , Toronto,","place":["Canada"]},{"name":"Department of Medical Imaging, Sunnybrook Health Sciences Centre , Toronto,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Lyn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pulmonary, Allergy, and Critical Care, Stanford University , Stanford, CA,","place":["United States"]},{"name":"Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University , Stanford, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Kuang (Julie)","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pulmonary, Allergy, and Critical Care, Stanford University , 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