{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:03:03Z","timestamp":1790650983243,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008593","name":"European Respiratory Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Research Collaboration","award":["EMBARC4"],"award-info":[{"award-number":["EMBARC4"]}]},{"name":"Alarmin Therapeutics"},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centauri Therapeutics"},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Asthma and Lung UK Chair of Respiratory Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>The frequent exacerbator phenotype was previously defined using a threshold of \u2009\u22653 exacerbations per year in bronchiectasis. However, the contribution of each prior exacerbation to future risk as well as the influence of severe exacerbations and different etiologies and regions remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To quantify the risk associated with each prior exacerbation of bronchiectasis in predicting future exacerbations and severe exacerbations, and to determine whether this association varies across different etiologies and geographic regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from the European Bronchiectasis Registry (EMBARC), including 30 countries across Europe and Asia. The association between baseline exacerbation history and future exacerbations was tested using negative binomial regression over up to 5\u2009years of follow-up. Severe exacerbations were defined as those requiring hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>A total of 19\u200a324 patients with bronchiectasis were included. Each prior exacerbation was associated with an increased risk of exacerbations and severe exacerbations. Incidence rate ratio (IRR) for future exacerbations was 1.45 (95% CI 1.34-1.58, P\u2009&amp;lt;\u2009.001) for 1 exacerbation; 1.84 (95% CI 1.69-1.99, P\u2009&amp;lt;\u2009.001) for 2 exacerbations; 2.50 (95% CI 2.29-2.73, P\u2009&amp;lt;\u2009.001) for 3 exacerbations; and 3.56 (95% CI 3.32-3.82, P\u2009&amp;lt;\u2009.001) for patients with 4 or more prior exacerbations. Additionally, 1 prior severe exacerbation was associated with increased risk of exacerbation (IRR\u2009=\u20091.52, 95% CI 1.45-1.60, P\u2009&amp;lt;\u2009.001) and strongly associated with future severe exacerbations (IRR\u2009=\u20093.96, 95% CI 3.71-4.22, P\u2009&amp;lt;\u2009.001). The frequent exacerbator phenotype was consistent across different etiologies and geographic regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The frequent exacerbator phenotype is highly consistent across patient subgroups and regions. Each prior exacerbation is associated with a progressively higher risk, with no definitive threshold-defining high risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajrccm\/aamag297","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:46:35Z","timestamp":1781178395000},"page":"1999-2010","source":"Crossref","is-referenced-by-count":2,"title":["The frequent exacerbator phenotype in bronchiectasis revisited: data from EMBARC registry"],"prefix":"10.1093","volume":"212","author":[{"given":"Oriol","family":"Sibila","sequence":"first","affiliation":[{"name":"Respiratory Department, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERES , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Perea","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Research Group of Inflammation and Repair in Respiratory Diseases , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre Regis","family":"Burgel","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and French Cystic Fibrosis National Reference Center, H\u00f4pital Cochin, AP-HP and Universit\u00e9 Paris Cit\u00e9, Inserm U1016, Institut Cochin , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Polverino","sequence":"additional","affiliation":[{"name":"Pneumology Department, Hospital Universitari Vall d\u2018Hebron, Vall d\u2019Hebron Institut de Recerca (VHIR), Vall d\u2019Hebron Barcelona Hospital Campus, CIBERES , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C","family":"Hull","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School , Dundee,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete B","family":"Long","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School , Dundee,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0417-7607","authenticated-orcid":false,"given":"Sanjay H","family":"Chotirmall","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore,","place":["Singapore"]},{"name":"Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital , Singapore,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Shteinberg","sequence":"additional","affiliation":[{"name":"Pulmonology Institute and CF Center, Carmel Medical Center , Haifa,","place":["Israel"]},{"name":"B. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology , Haifa,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Pollock","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School , Dundee,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Stobo","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School , Dundee,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Lind","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School , Dundee,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Haworth","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital NHS Foundation Trust and University of Cambridge , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Dimakou","sequence":"additional","affiliation":[{"name":"ATTICA Rehabilitation Center , Athens,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos","family":"Bossios","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Allergy, Karolinska University Hospital , Stockholm,","place":["Sweden"]},{"name":"Division of Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institute , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Loebinger","sequence":"additional","affiliation":[{"name":"Host Defence Unit, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Dhar","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, CK Birla Hospitals , Kolkata,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Fu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji University , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pontus","family":"Mersch","sequence":"additional","affiliation":[{"name":"Department of Medicine V, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich, Member of the German Center for Lung Research , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Rademacher","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany; Biomedical Research in End-Stage and Obstructive Lung Disease Hannover, German Centre for Lung Research , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital , Seoul,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Lorent","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, University Hospitals Leuven , Leuven,","place":["Belgium"]},{"name":"Department of Chronic Diseases, Metabolism and Aging, BREATHE Laboratory, KU Leuven , Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Blasi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, University of Milan , Milan,","place":["Italy"]},{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca\u2019 Granda Ospedale Maggiore Policlinico , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Vendrell","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Dr Trueta University Hospital, Girona Biomedical Research Institute, Cerca. University of Girona , Girona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Goeminne","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, AZ Nikolaas , Sint-Niklaas,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Ringshausen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany; Biomedical Research in End-Stage and Obstructive Lung Disease Hannover, German Centre for Lung Research , Hannover,","place":["Germany"]},{"name":"European Reference Network on Rare and Complex Respiratory Diseases , Frankfurt am Main,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8566-0344","authenticated-orcid":false,"given":"Anthony","family":"De Soyza","sequence":"additional","affiliation":[{"name":"Population and Health Sciences Institute, NIHR Biomedical Research Centre for Aging, Newcastle University and Department of Respiratory Medicine, Newcastle upon Tyne NHS Foundation Trust , Newcastle upon Tyne,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Aliberti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University , Milan 20072,","place":["Italy"]},{"name":"Respiratory Unit, IRCCS Humanitas Research Hospital , Milan 20089,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D","family":"Chalmers","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School , Dundee,","place":["United Kingdom"]},{"name":"Radcliffe Department of Medicine, University of Oxford , Oxford,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"2026082703550346600_aamag297-B1","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/S2213-2600(21)00277-0","article-title":"Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults for use in clinical trials: international consensus recommendations","volume":"10","author":"Aliberti","year":"2022","journal-title":"Lancet Respir Med"},{"key":"2026082703550346600_aamag297-B2","doi-asserted-by":"publisher","first-page":"240055","DOI":"10.1183\/16000617.0055-2024","article-title":"Pathophysiology and genomics of bronchiectasis","volume":"33","author":"Perea","year":"2024","journal-title":"Eur Respir Rev"},{"key":"2026082703550346600_aamag297-B3","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/S0140-6736(18)31767-7","article-title":"Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity","volume":"392","author":"Flume","year":"2018","journal-title":"Lancet"},{"key":"2026082703550346600_aamag297-B4","doi-asserted-by":"publisher","first-page":"2100777","DOI":"10.1183\/13993003.00777-2021","article-title":"Heterogeneity of treatment response in bronchiectasis clinical trials","volume":"59","author":"Sibila","year":"2022","journal-title":"Eur Respir J"},{"key":"2026082703550346600_aamag297-B5","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1164\/rccm.201309-1575OC","article-title":"The Bronchiectasis Severity Index: an international derivation and validation study","volume":"189","author":"Chalmers","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026082703550346600_aamag297-B6","doi-asserted-by":"publisher","first-page":"240085","DOI":"10.1183\/16000617.0085-2024","article-title":"Exacerbations of bronchiectasis","volume":"33","author":"De Angelis","year":"2024","journal-title":"Eur Respir Rev"},{"key":"2026082703550346600_aamag297-B7","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S2213-2600(23)00093-0","article-title":"Bronchiectasis in Europe: data on disease characteristics from the European Bronchiectasis Registry (EMBARC)","volume":"11","author":"Chalmers","year":"2023","journal-title":"Lancet Respir Med"},{"key":"2026082703550346600_aamag297-B8","doi-asserted-by":"publisher","first-page":"e1269","DOI":"10.1016\/S2214-109X(19)30327-4","article-title":"Bronchiectasis in India: results from the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) and Respiratory Research Network of India Registry","volume":"7","author":"Dhar","year":"2019","journal-title":"Lancet Glob Health"},{"key":"2026082703550346600_aamag297-B9","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1164\/rccm.201711-2202OC","article-title":"Characterization of the \u201cfrequent exacerbator phenotype\u201d in bronchiectasis","volume":"197","author":"Chalmers","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2026082703550346600_aamag297-B10","doi-asserted-by":"publisher","first-page":"2501126","DOI":"10.1183\/13993003.01126-2025","article-title":"European Respiratory Society clinical practice guideline for the management of adult bronchiectasis","volume":"66","author":"Chalmers","year":"2025","journal-title":"Eur Respir J"},{"key":"2026082703550346600_aamag297-B11","doi-asserted-by":"publisher","first-page":"1700629","DOI":"10.1183\/13993003.00629-2017","article-title":"European Respiratory Society guidelines for the management of adult bronchiectasis","volume":"50","author":"Polverino","year":"2017","journal-title":"Eur Respir J"},{"key":"2026082703550346600_aamag297-B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/thoraxjnl-2018-212463","article-title":"British Thoracic Society Guideline for bronchiectasis in adults","volume":"74","author":"Hill","year":"2019","journal-title":"Thorax"},{"key":"2026082703550346600_aamag297-B13","doi-asserted-by":"crossref","first-page":"240038","DOI":"10.1183\/16000617.0038-2024","article-title":"Infection and the microbiome in bronchiectasis","volume":"33","author":"Aog\u00e1in","year":"2024","journal-title":"Eur Respir Rev"},{"key":"2026082703550346600_aamag297-B14","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1164\/rccm.202309-1614OC","article-title":"The association between bronchiectasis and chronic obstructive pulmonary disease: data from the European Bronchiectasis Registry (EMBARC)","volume":"210","author":"Polverino","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"2026082703550346600_aamag297-B15","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.chest.2024.05.023","article-title":"Primary ciliary dyskinesia in adult bronchiectasis: data from the German bronchiectasis registry PROGNOSIS","volume":"166","author":"Ewen","year":"2024","journal-title":"Chest"},{"key":"2026082703550346600_aamag297-B16","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.chest.2024.06.3843","article-title":"Aspergillus serologic findings and clinical outcomes in patients with bronchiectasis: data from the European Bronchiectasis Registry","volume":"167","author":"Pollock","year":"2025","journal-title":"Chest"},{"key":"2026082703550346600_aamag297-B17","doi-asserted-by":"publisher","first-page":"1701953","DOI":"10.1183\/13993003.01953-2017","article-title":"The independent contribution of Pseudomonas aeruginosa infection to long-term clinical outcomes in bronchiectasis","volume":"51","author":"Ara\u00fajo","year":"2018","journal-title":"Eur Respir J"},{"key":"2026082703550346600_aamag297-B18","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.arbres.2022.09.004","article-title":"Pathophysiology of chronic bronchial infection in bronchiectasis","volume":"59","author":"Solarat","year":"2023","journal-title":"Arch Bronconeumol"},{"key":"2026082703550346600_aamag297-B19","doi-asserted-by":"publisher","first-page":"2500054","DOI":"10.1183\/13993003.00054-2025","article-title":"Sputum metagenomics in bronchiectasis reveals pan-European variation: an EMBARC-BRIDGE study","volume":"66","author":"Thng","year":"2025","journal-title":"Eur Respir J"},{"key":"2026082703550346600_aamag297-B20","doi-asserted-by":"publisher","first-page":"00081","DOI":"10.1183\/23120541.00081-2015","article-title":"The EMBARC European Bronchiectasis Registry: protocol for an international observational study","volume":"2","author":"Chalmers","year":"2016","journal-title":"ERJ Open Res"},{"key":"2026082703550346600_aamag297-B21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1136\/thoraxjnl-2014-205918","article-title":"Quality of Life Questionnaire\u2013Bronchiectasis: final psychometric analyses and determination of minimal important difference scores","volume":"70","author":"Quittner","year":"2015","journal-title":"Thorax"},{"key":"2026082703550346600_aamag297-B22","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/S2213-2600(24)00176-0","article-title":"Rethinking bronchiectasis as an inflammatory disease","volume":"12","author":"Long","year":"2024","journal-title":"Lancet Respir Med"},{"key":"2026082703550346600_aamag297-B23","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S2213-2600(25)00160-2","article-title":"Symptoms, risk of future exacerbations, and response to long-term macrolide treatment in bronchiectasis: an observational study","volume":"13","author":"Sibila","year":"2025","journal-title":"Lancet Respir Med"},{"key":"2026082703550346600_aamag297-B24","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1164\/rccm.202403-0473PP","article-title":"The precision medicine era of bronchiectasis","volume":"210","author":"Chotirmall","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"2026082703550346600_aamag297-B25","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1056\/NEJMoa2411664","article-title":"Phase 3 trial of the DPP-1 inhibitor brensocatib in bronchiectasis","volume":"392","author":"Chalmers","year":"2025","journal-title":"N Engl J Med"},{"key":"2026082703550346600_aamag297-B26","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1056\/NEJMoa2021713","article-title":"Phase 2 trial of the DPP-1 inhibitor brensocatib in bronchiectasis","volume":"383","author":"Chalmers","year":"2020","journal-title":"N Engl J Med"},{"key":"2026082703550346600_aamag297-B27","doi-asserted-by":"publisher","first-page":"2401551","DOI":"10.1183\/13993003.01551-2024","article-title":"Cathepsin C (dipeptidyl peptidase 1) inhibition in adults with bronchiectasis: AIRLEAF, a phase II randomised, double-blind, placebo-controlled, dose-finding study","volume":"65","author":"Chalmers","year":"2025","journal-title":"Eur Respir J"},{"key":"2026082703550346600_aamag297-B28","doi-asserted-by":"publisher","first-page":"2401050","DOI":"10.1183\/13993003.01050-2024","article-title":"Targeting neutrophil serine proteases in bronchiectasis","volume":"65","author":"Chalmers","year":"2025","journal-title":"Eur Respir J"},{"key":"2026082703550346600_aamag297-B29","doi-asserted-by":"publisher","first-page":"2500081","DOI":"10.1183\/13993003.00081-2025","article-title":"Neutrophil-derived biomarkers in bronchiectasis: identifying a common therapeutic target","volume":"66","author":"Chalmers","year":"2025","journal-title":"Eur Respir J"},{"key":"2026082703550346600_aamag297-B30","doi-asserted-by":"publisher","first-page":"1701289","DOI":"10.1183\/13993003.01289-2017","article-title":"Standardised classification of the aetiology of bronchiectasis using an objective algorithm","volume":"50","author":"Ara\u00fajo","year":"2017","journal-title":"Eur Respir J"},{"key":"2026082703550346600_aamag297-B31","doi-asserted-by":"publisher","first-page":"2501309","DOI":"10.1183\/13993003.01309-2025","article-title":"Emerging therapies in bronchiectasis","volume":"66","author":"Sibila","year":"2025","journal-title":"Eur Respir J"},{"key":"2026082703550346600_aamag297-B32","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1164\/rccm.202105-1137LE","article-title":"The impact of the COVID-19 pandemic on exacerbations and symptoms in bronchiectasis: a prospective study","volume":"204","author":"Crichton","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2026082703550346600_aamag297-B33","doi-asserted-by":"publisher","first-page":"1700051","DOI":"10.1183\/13993003.00051-2017","article-title":"Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research","volume":"49","author":"Hill","year":"2017","journal-title":"Eur Respir J"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article-pdf\/doi\/10.1093\/ajrccm\/aamag297\/68585760\/aamag297.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/9\/1999\/68585760\/aamag297.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/9\/1999\/68585760\/aamag297.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:55:08Z","timestamp":1787817308000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/212\/9\/1999\/8714043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":33,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,6,25]]},"published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajrccm\/aamag297","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,6,25]]}}}