{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:41:38Z","timestamp":1792071698926,"version":"4.4.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/P34023"],"award-info":[{"award-number":["10.55776\/P34023"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/P34266"],"award-info":[{"award-number":["10.55776\/P34266"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/F83"],"award-info":[{"award-number":["10.55776\/F83"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Cardiac sarcoidosis is a granulomatous inflammatory disease that frequently progresses to irreversible myocardial fibrosis and lethal conduction abnormalities. While mechanistic target of rapamycine complex 1 (mTORC1)\u2013dependent macrophage activation has been implicated in this process, exactly how granulomatous inflammation is mechanistically converted into fibrotic remodeling at the level of macrophage effector function remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We employed a mouse model with myeloid-specific Tsc2 deletion that recapitulates key features of human cardiac sarcoidosis. Single-cell RNA sequencing, bioinformatic analyses, histopathology, in vitro functional studies in murine and human macrophages, and in vivo pharmacologic inhibition were integrated to define macrophage-intrinsic mechanisms driving granuloma-associated cardiac fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Constitutive mTORC1 activation induced a fibrogenic macrophage (FibMac) population in the heart characterized by expression of Cd63, Spp1, Gpnmb, and Fabp5 and arising through a TGF-\u03b2\u2013dependent monocyte-to-FibMac differentiation process. We identified matrix metalloproteinase 12 (MMP12) as a macrophage-intrinsic inducer and dominant effector of this program. Recombinant MMP12 was sufficient to enforce fibrogenic macrophage differentiation and promote macrophage clustering and epithelioid features in both mouse and human macrophages. Conversely, selective MMP12 inhibition disrupted granuloma architecture, reduced fibroblast activation, and attenuated myocardial fibrosis in vivo, with concomitant improvement of cardiac conduction. In human cardiac sarcoidosis tissue, MMP12 colocalized with FibMac markers within granulomas, and reanalysis of published human fibrosis datasets revealed MMP12 expression within analogous fibrogenic macrophage populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings uncover MMP12 as a macrophage-intrinsic inducer and sustainer that links fibrogenic macrophage identity to granuloma architecture and cardiac fibrosis in sarcoidosis. Targeting this effector axis provides a therapeutic strategy distinct from upstream mTORC1 inhibition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajrccm\/aamag354","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:36:04Z","timestamp":1785332164000},"page":"2409-2423","source":"Crossref","is-referenced-by-count":2,"title":["MMP12 induces fibrogenic macrophage differentiation to drive granuloma-associated cardiac fibrosis"],"prefix":"10.1093","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2385-1866","authenticated-orcid":false,"given":"Mario","family":"Mazi\u0107","sequence":"first","affiliation":[{"name":"Center for Pathobiochemistry and Genetics, Medical University of Vienna , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarice X","family":"Lim","sequence":"additional","affiliation":[{"name":"Center for Pathobiochemistry and Genetics, Medical University of Vienna , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyal","family":"Saha","sequence":"additional","affiliation":[{"name":"Center for Pathobiochemistry and Genetics, Medical University of Vienna , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"El-Jammal","sequence":"additional","affiliation":[{"name":"Center for Pathobiochemistry and Genetics, Medical University of Vienna , Vienna,","place":["Austria"]},{"name":"Laboratory of Tissue Biology and Therapeutic Engineering, CNRS UMR5305, University Claude Bernard Lyon 1, Institute of Biology and Chemistry of Proteins , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roko","family":"\u0160ango","sequence":"additional","affiliation":[{"name":"Center for Pathobiochemistry and Genetics, Medical University of Vienna , Vienna,","place":["Austria"]},{"name":"Centre for Microbiology and Environmental Systems Science, University of Vienna , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayeba","family":"Ghazi","sequence":"additional","affiliation":[{"name":"Center for Pathobiochemistry and Genetics, Medical University of Vienna , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armela","family":"Jahi\u0107","sequence":"additional","affiliation":[{"name":"Center for Pathobiochemistry and Genetics, Medical University of Vienna , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ettel","sequence":"additional","affiliation":[{"name":"Center for Pathobiochemistry and Genetics, Medical University of Vienna , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Jager","sequence":"additional","affiliation":[{"name":"Clinical Cardiology Academic Group, Molecular and Clinical Research Science, Institute St George\u2019s University of London , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Asimaki","sequence":"additional","affiliation":[{"name":"Clinical Cardiology Academic Group, Molecular and Clinical Research Science, Institute St George\u2019s University of London , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary N","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Clinical Cardiology Academic Group, CRY Centre for Cardiac Pathology, St George\u2019s University of London , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Todt","sequence":"additional","affiliation":[{"name":"Center for Physiology and Pharmacology, Medical University of Vienna , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Kratky","sequence":"additional","affiliation":[{"name":"Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz , Graz,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3342-7583","authenticated-orcid":false,"given":"Markus","family":"Hengstschl\u00e4ger","sequence":"additional","affiliation":[{"name":"Center for Pathobiochemistry and Genetics, Medical University of Vienna , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjin","family":"Yang","sequence":"additional","affiliation":[{"name":"Foresee Pharmaceuticals Co., Ltd., Research and Development, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-0797","authenticated-orcid":false,"given":"Thomas","family":"Weichhart","sequence":"additional","affiliation":[{"name":"Center for Pathobiochemistry and Genetics, Medical University of Vienna , Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"2026093006123223100_aamag354-B1","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1126\/science.1176009","article-title":"The extracellular matrix: not just pretty fibrils","volume":"326","author":"Hynes","year":"2009","journal-title":"Science"},{"key":"2026093006123223100_aamag354-B2","doi-asserted-by":"publisher","first-page":"e2021135118","DOI":"10.1073\/pnas.2021135118","article-title":"Contractility, focal adhesion orientation, and stress fiber orientation drive cancer cell polarity and migration along wavy ECM substrates","volume":"118","author":"Fischer","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026093006123223100_aamag354-B3","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1152\/physrev.00008.2011","article-title":"Matricellular proteins in cardiac adaptation and disease","volume":"92","author":"Frangogiannis","year":"2012","journal-title":"Physiol Rev"},{"key":"2026093006123223100_aamag354-B4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1080\/14789450.2018.1421947","article-title":"Proteomic analysis of the cardiac extracellular matrix: clinical research applications","volume":"15","author":"Lindsey","year":"2018","journal-title":"Expert Rev Proteomics"},{"key":"2026093006123223100_aamag354-B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.matbio.2018.08.007","article-title":"Matrix modeling and remodeling: a biological interplay regulating tissue homeostasis and diseases","volume":"75-76","author":"Karamanos","year":"2019","journal-title":"Matrix Biol"},{"key":"2026093006123223100_aamag354-B6","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1172\/JCI31487","article-title":"Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases","volume":"117","author":"Wynn","year":"2007","journal-title":"J Clin Invest"},{"key":"2026093006123223100_aamag354-B7","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41569-020-00504-1","article-title":"Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches","volume":"18","author":"L\u00f3pez","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"2026093006123223100_aamag354-B8","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1083\/jcb.201004082","article-title":"Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression","volume":"190","author":"Liu","year":"2010","journal-title":"J Cell Biol"},{"key":"2026093006123223100_aamag354-B9","doi-asserted-by":"publisher","first-page":"eabg6497","DOI":"10.1126\/sciadv.abg6497","article-title":"Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration","volume":"7","author":"Allanki","year":"2021","journal-title":"Sci Adv"},{"key":"2026093006123223100_aamag354-B10","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1172\/JCI98215","article-title":"Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart","volume":"128","author":"Fu","year":"2018","journal-title":"J Clin Invest"},{"key":"2026093006123223100_aamag354-B11","doi-asserted-by":"publisher","first-page":"eadd8945","DOI":"10.1126\/sciimmunol.add8945","article-title":"Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation","volume":"8","author":"Fabre","year":"2023","journal-title":"Sci Immunol"},{"key":"2026093006123223100_aamag354-B12","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1056\/NEJMra2101555","article-title":"Challenges of sarcoidosis and its management","volume":"385","author":"Drent","year":"2021","journal-title":"N Engl J Med"},{"key":"2026093006123223100_aamag354-B13","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1007\/s12350-016-0658-1","article-title":"Isolated cardiac sarcoidosis: a focused review of an under-recognized entity","volume":"25","author":"Okada","year":"2018","journal-title":"J Nucl Cardiol"},{"key":"2026093006123223100_aamag354-B14","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1378\/chest.90.4.528","article-title":"Utility of endomyocardial biopsy in the diagnosis of cardiac sarcoidosis","volume":"90","author":"Ratner","year":"1986","journal-title":"Chest"},{"key":"2026093006123223100_aamag354-B15","doi-asserted-by":"publisher","first-page":"e1197","DOI":"10.1161\/CIR.0000000000001240","article-title":"Diagnosis and management of cardiac sarcoidosis: a scientific statement from the American Heart Association","volume":"149","author":"Cheng","year":"2024","journal-title":"Circulation"},{"key":"2026093006123223100_aamag354-B16","doi-asserted-by":"publisher","first-page":"e030478","DOI":"10.1161\/JAHA.123.030478","article-title":"An mTORC1-dependent mouse model for cardiac sarcoidosis","volume":"12","author":"Bueno-Beti","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"2026093006123223100_aamag354-B17","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cmet.2006.05.011","article-title":"Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation","volume":"4","author":"Vats","year":"2006","journal-title":"Cell Metab"},{"key":"2026093006123223100_aamag354-B18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"2026093006123223100_aamag354-B19","doi-asserted-by":"publisher","first-page":"e23223","DOI":"10.1016\/j.heliyon.2023.e23223","article-title":"CD163 protein inhibits lipopolysaccharide-induced macrophage transformation from M2 to M1 involved in disruption of the TWEAK-Fn14 interaction","volume":"10","author":"Chen","year":"2024","journal-title":"Heliyon"},{"key":"2026093006123223100_aamag354-B20","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1093\/molehr\/gau034","article-title":"Matrix metalloproteinase-27 is expressed in CD163+\/CD206+ M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions","volume":"20","author":"Cominelli","year":"2014","journal-title":"Mol Human Reprod"},{"key":"2026093006123223100_aamag354-B21","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1164\/rccm.201202-0302OC","article-title":"Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans","volume":"186","author":"Yu","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"2026093006123223100_aamag354-B22","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1210\/me.2014-1092","article-title":"Lipocalin 2 is a regulator of macrophage polarization and NF-\u03baB\/STAT3 pathway activation","volume":"28","author":"Guo","year":"2014","journal-title":"Mol Endocrinol"},{"key":"2026093006123223100_aamag354-B23","doi-asserted-by":"publisher","first-page":"56","DOI":"10.2215\/CJN.03390509","article-title":"Upregulation of monocyte\/macrophage HGFIN (Gpnmb\/Osteoactivin) expression in end-stage renal disease","volume":"5","author":"Pahl","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"2026093006123223100_aamag354-B24","doi-asserted-by":"publisher","first-page":"4855","DOI":"10.4049\/jimmunol.1602175","article-title":"The upregulation of integrin \u03b1D\u03b22 (CD11d\/CD18) on inflammatory macrophages promotes macrophage retention in vascular lesions and development of atherosclerosis","volume":"198","author":"Aziz","year":"2017","journal-title":"J Immunol"},{"key":"2026093006123223100_aamag354-B25","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.matbio.2008.12.002","article-title":"In vitro degradation of human tropoelastin by MMP-12 and the generation of matrikines from domain 24","volume":"28","author":"Taddese","year":"2009","journal-title":"Matrix Biol"},{"key":"2026093006123223100_aamag354-B26","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1002\/(sici)1097-4644(19991201)75:3&lt;505::aid-jcb14&gt;3.3.co;2-9","article-title":"Galectin-3 regulates the adhesive interaction between breast carcinoma cells and elastin","volume":"75","author":"Ochieng","year":"1999","journal-title":"J Cell Biochem"},{"key":"2026093006123223100_aamag354-B27","doi-asserted-by":"publisher","first-page":"12484","DOI":"10.1074\/jbc.M609505200","article-title":"The elastin receptor complex transduces signals through the catalytic activity of its Neu-1 subunit","volume":"282","author":"Duca","year":"2007","journal-title":"J Biol Chem"},{"key":"2026093006123223100_aamag354-B28","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s40261-020-00981-9","article-title":"First-in-man safety, tolerability, and pharmacokinetics of a novel and highly selective inhibitor of matrix metalloproteinase-12, FP-025: results from two randomized studies in healthy subjects","volume":"41","author":"Abd-Elaziz","year":"2021","journal-title":"Clin Drug Investig"},{"key":"2026093006123223100_aamag354-B29","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: from mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"2026093006123223100_aamag354-B30","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1080\/15384101.2016.1152435","article-title":"Common pathway signature in lung and liver fibrosis","volume":"15","author":"Makarev","year":"2016","journal-title":"Cell Cycle"},{"key":"2026093006123223100_aamag354-B31","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41392-022-01070-3","article-title":"Targeting fibrosis: mechanisms and clinical trials","volume":"7","author":"Zhao","year":"2022","journal-title":"Sig Transduct Target Ther"},{"key":"2026093006123223100_aamag354-B32","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/ni.3655","article-title":"Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression","volume":"18","author":"Linke","year":"2017","journal-title":"Nat Immunol"},{"key":"2026093006123223100_aamag354-B33","doi-asserted-by":"publisher","first-page":"2002695","DOI":"10.1183\/13993003.02695-2020","article-title":"Phagosome-regulated mTOR signalling during sarcoidosis granuloma biogenesis","volume":"57","author":"Crouser","year":"2021","journal-title":"Eur Respir J"},{"key":"2026093006123223100_aamag354-B34","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1067\/mva.2002.120382","article-title":"Monocyte chemotactic activity in human abdominal aortic aneurysms: role of elastin degradation peptides and the 67-kD cell surface elastin receptor","volume":"35","author":"Hance","year":"2002","journal-title":"J Vasc Surg"},{"key":"2026093006123223100_aamag354-B35","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1053\/ejvs.2002.1750","article-title":"Serum concentrations of elastin-derived peptides in patients with specific manifestations of atherosclerotic disease","volume":"24","author":"Petersen","year":"2002","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2026093006123223100_aamag354-B36","doi-asserted-by":"publisher","first-page":"10474","DOI":"10.1038\/s41598-018-28492-w","article-title":"Effects of collagen-derived bioactive peptides and natural antioxidant compounds on proliferation and matrix protein synthesis by cultured normal human dermal fibroblasts","volume":"8","author":"Edgar","year":"2018","journal-title":"Sci Rep"},{"key":"2026093006123223100_aamag354-B37","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.biocel.2007.08.011","article-title":"The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?","volume":"40","author":"Moeller","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"2026093006123223100_aamag354-B38","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1164\/rccm.200803-490OC","article-title":"Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis","volume":"179","author":"Crouser","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"2026093006123223100_aamag354-B39","doi-asserted-by":"publisher","first-page":"553949","DOI":"10.3389\/fimmu.2020.553949","article-title":"Matrix metalloproteinase-12 is required for granuloma progression","volume":"11","author":"Mohan","year":"2020","journal-title":"Front Immunol"},{"key":"2026093006123223100_aamag354-B40","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1165\/rcmb.2006-0471OC","article-title":"Essential role of MMP-12 in Fas-induced lung fibrosis","volume":"37","author":"Matute-Bello","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026093006123223100_aamag354-B41","doi-asserted-by":"publisher","first-page":"7143","DOI":"10.1016\/j.cell.2024.09.034","article-title":"Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target","volume":"187","author":"Zhang","year":"2024","journal-title":"Cell"},{"key":"2026093006123223100_aamag354-B42","doi-asserted-by":"publisher","first-page":"107245","DOI":"10.1016\/j.phrs.2024.107245","article-title":"The current landscape of antifibrotic therapy across different organs: a systematic approach","volume":"205","author":"Fuster-Mart\u00ednez","year":"2024","journal-title":"Pharmacol Res"},{"key":"2026093006123223100_aamag354-B43","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/s41586-024-08008-5","article-title":"Targeting immune-fibroblast cell communication in heart failure","volume":"635","author":"Amrute","year":"2024","journal-title":"Nature"},{"key":"2026093006123223100_aamag354-B44","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/s41586-024-08105-5","article-title":"Immune responses in checkpoint myocarditis across heart, blood and tumour","volume":"636","author":"Blum","year":"2024","journal-title":"Nature"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article-pdf\/doi\/10.1093\/ajrccm\/aamag354\/70344483\/aamag354.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/10\/2409\/70344483\/aamag354.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/10\/2409\/70344483\/aamag354.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:12:39Z","timestamp":1790763159000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/212\/10\/2409\/8746785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":44,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,7,29]]},"published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajrccm\/aamag354","relation":{},"ISSN":["1535-4970"],"issn-type":[{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,7,29]]}}}