{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:00:25Z","timestamp":1790766025821,"version":"4.1.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["490745655"],"award-info":[{"award-number":["490745655"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01 HL157384"],"award-info":[{"award-number":["5R01 HL157384"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01 HL147059"],"award-info":[{"award-number":["5R01 HL147059"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1S10OD036287-01"],"award-info":[{"award-number":["1S10OD036287-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["SCR_021988"],"award-info":[{"award-number":["SCR_021988"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Cancer Institute through the Cancer Center","award":["P30CA06934"],"award-info":[{"award-number":["P30CA06934"]}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["P500PB_206633"],"award-info":[{"award-number":["P500PB_206633"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gene Lay Institute Postdoctoral Fellowship","award":["GR1003002"],"award-info":[{"award-number":["GR1003002"]}]},{"name":"Gene Lay Institute Postdoctoral Fellowship","award":["T32HL116275"],"award-info":[{"award-number":["T32HL116275"]}]},{"name":"Gene Lay Institute Postdoctoral Fellowship","award":["K08HL177151"],"award-info":[{"award-number":["K08HL177151"]}]},{"name":"Gene Lay Institute Postdoctoral Fellowship","award":["U19 AI110495"],"award-info":[{"award-number":["U19 AI110495"]}]},{"name":"Gene Lay Institute Postdoctoral Fellowship","award":["K08HL140175"],"award-info":[{"award-number":["K08HL140175"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Yes-associated protein (YAP)\u2013mediated fibroblast mechanoactivation is an important driver of fibrosis in idiopathic pulmonary fibrosis (IPF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize the role of ADAM with thrombospondin motif 14 (ADAMTS14) in YAP-mediated fibroblast mechanoactivation and pulmonary fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We disrupted ADAMTS14 expression in primary human lung fibroblasts (HLFs) and demonstrated its role in YAP nuclear translocation and fibroblast activation. We confirmed the in vivo relevance of ADAMTS14 in an IPF patient cohort using transcriptomic studies. ADAMTS14-deficient fibroblasts were further characterized in mechanistic studies combining advanced microscopy, unbiased proteomics, and co-immunoprecipitation with functional mechanobiology assays to delineate substrate\u2013matrix interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>An unbiased siRNA screen identified ADAMTS14 as a regulator of YAP-mediated fibroblast activation and profibrotic activity. Transcriptomic analyses of patient samples with fibrotic lung disease identified an ADAMTS14-expressing fibroblast population characterized by excessive collagen matrix synthesis and located within fibroblastic foci of IPF patients. Disruption of ADAMTS14 expression in IPF patient\u2013derived HLFs reduced profibrotic gene expression and attenuated the response to TGF\u03b2. Mechanistically, we identified collagen V as a novel functionally relevant ADAMTS14 substrate essential for matrix stability. ADAMTS14-deficient fibroblasts produced an unstable extracellular matrix, leading to disorganized focal adhesions, impaired force transmission, and reduced focal adhesion\u2013FAK-AKT signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identify a novel ADAMTS14\u2013collagen V\u2013focal adhesion axis as a potential driver of fibroblast activation in IPF, linking extracellular proteolytic matrix remodeling to focal adhesion dynamics and YAP-mediated mechanoactivation. This feed-forward circuit provides a new mechanistic framework for pulmonary fibrosis and identifies potential novel therapeutic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajrccm\/aamag396","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T11:30:58Z","timestamp":1785065458000},"page":"2386-2408","source":"Crossref","is-referenced-by-count":1,"title":["ADAMTS14 is a novel modulator of fibroblast mechanoactivation in pulmonary fibrosis"],"prefix":"10.1093","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-6641","authenticated-orcid":false,"given":"Ingo","family":"Ganzleben","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Broad Institute of Massachusetts Institute of Technology and Harvard , Cambridge, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela M","family":"Santos","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyce","family":"Segal","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell C","family":"McCabe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado , Aurora, CO,","place":["United States"]},{"name":"Cancer Center Proteomics Core, School of Medicine, University of Colorado , Aurora, CO,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado , Aurora, CO,","place":["United States"]},{"name":"Cancer Center Proteomics Core, School of Medicine, University of Colorado , Aurora, CO,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Hyun","family":"Yun","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School , Boston, MA,","place":["United States"]},{"name":"Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology , Cambridge, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Krug","sequence":"additional","affiliation":[{"name":"John A. Paulson School of Engineering and Applied Sciences, Department of Physics, Harvard University , Cambridge, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Weitz","sequence":"additional","affiliation":[{"name":"John A. Paulson School of Engineering and Applied Sciences, Department of Physics, Harvard University , Cambridge, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desmond","family":"Chow Ming Chia","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Ortiz Diaz","sequence":"additional","affiliation":[{"name":"Summer Research Trainee Program, Massachusetts General Hospital , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Pantano","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard T.H. Chan School of Public Health , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannan","family":"Ho Sui","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard T.H. Chan School of Public Health , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel S","family":"Knipe","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Brazee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Pronzati","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"Black","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lida P","family":"Hariri","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]},{"name":"Department of Pathology, Massachusetts General Hospital, Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedrickx","family":"Godbout","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG , Ingelheim am Rhein,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Maier","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG , Ingelheim am Rhein,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas M","family":"Altenburger","sequence":"additional","affiliation":[{"name":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]},{"name":"Broad Institute of Massachusetts Institute of Technology and Harvard , Cambridge, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Kooistra","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten R","family":"Mempel","sequence":"additional","affiliation":[{"name":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Seither","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG , Ingelheim am Rhein,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG , Ingelheim am Rhein,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramnik J","family":"Xavier","sequence":"additional","affiliation":[{"name":"Broad Institute of Massachusetts Institute of Technology and Harvard , Cambridge, MA,","place":["United States"]},{"name":"Division of Gastroenterology, Massachusetts General Hospital, and Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D","family":"Medoff","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"2026093006132535600_aamag396-B1","doi-asserted-by":"publisher","first-page":"e44","DOI":"10.1164\/rccm.201807-1255ST","article-title":"Diagnosis of idiopathic pulmonary fibrosis. An official ATS\/ERS\/JRS\/ALAT clinical practice guideline","volume":"198","author":"Raghu","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2026093006132535600_aamag396-B2","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/S0140-6736(22)01052-2","article-title":"Interstitial lung diseases","volume":"400","author":"Wijsenbeek","year":"2022","journal-title":"Lancet"},{"key":"2026093006132535600_aamag396-B3","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125185","article-title":"Registration of the extracellular matrix components constituting the fibroblastic focus in idiopathic pulmonary fibrosis","volume":"4","author":"Herrera","year":"2019","journal-title":"JCI Insight"},{"key":"2026093006132535600_aamag396-B4","doi-asserted-by":"publisher","first-page":"113993","DOI":"10.1016\/j.isci.2025.113993","article-title":"Mechanobiology and the extracellular matrix in pulmonary fibrosis","volume":"28","author":"Ganzleben","year":"2025","journal-title":"iScience"},{"key":"2026093006132535600_aamag396-B5","doi-asserted-by":"publisher","first-page":"L344","DOI":"10.1152\/ajplung.00300.2014","article-title":"Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis","volume":"308","author":"Liu","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026093006132535600_aamag396-B6","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1083\/jcb.201004082","article-title":"Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression","volume":"190","author":"Liu","year":"2010","journal-title":"J Cell Biol"},{"key":"2026093006132535600_aamag396-B7","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1165\/rcmb.2012-0335OC","article-title":"Matrices of physiologic stiffness potently inactivate idiopathic pulmonary fibrosis fibroblasts","volume":"48","author":"Marinkovi\u0107","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026093006132535600_aamag396-B8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/0046-8177(95)90114-0","article-title":"Significance of early intra-alveolar fibrotic lesions and integrin expression in lung biopsy specimens from patients with idiopathic pulmonary fibrosis","volume":"26","author":"Fukuda","year":"1995","journal-title":"Hum Pathol"},{"key":"2026093006132535600_aamag396-B9","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.156115","article-title":"The UIP\/IPF fibroblastic focus is a collagen biosynthesis factory embedded in a distinct extracellular matrix","volume":"7","author":"Herrera","year":"2022","journal-title":"JCI Insight"},{"key":"2026093006132535600_aamag396-B10","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/978-3-319-49674-0_14","article-title":"Fibrillar collagens","volume":"82","author":"Bella","year":"2017","journal-title":"Subcell Biochem"},{"key":"2026093006132535600_aamag396-B11","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/s12931-021-01801-0","article-title":"Turnover of type I and III collagen predicts progression of idiopathic pulmonary fibrosis","volume":"22","author":"Jessen","year":"2021","journal-title":"Respir Res"},{"key":"2026093006132535600_aamag396-B12","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1164\/rccm.200204-373OC","article-title":"Fibroblastic foci in usual interstitial pneumonia: idiopathic versus collagen vascular disease","volume":"167","author":"Flaherty","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"2026093006132535600_aamag396-B13","doi-asserted-by":"publisher","first-page":"eaba1972","DOI":"10.1126\/sciadv.aba1972","article-title":"Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis","volume":"6","author":"Habermann","year":"2020","journal-title":"Sci Adv"},{"key":"2026093006132535600_aamag396-B14","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1165\/rcmb.2019-0296OC","article-title":"Screening for YAP inhibitors identifies statins as modulators of fibrosis","volume":"62","author":"Santos","year":"2020","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026093006132535600_aamag396-B15","doi-asserted-by":"publisher","first-page":"101066","DOI":"10.1016\/j.xgen.2025.101066","article-title":"Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases","volume":"6","author":"Jaiswal","year":"2026","journal-title":"Cell Genom"},{"key":"2026093006132535600_aamag396-B16","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2026093006132535600_aamag396-B17","doi-asserted-by":"publisher","first-page":"M111.014647","DOI":"10.1074\/mcp.M111.014647","article-title":"The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices","volume":"11","author":"Naba","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"2026093006132535600_aamag396-B18","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.261255","article-title":"Matrisome AnalyzeR\u2014a suite of tools to annotate and quantify ECM molecules in big datasets across organisms","volume":"136","author":"Petrov","year":"2023","journal-title":"J Cell Sci"},{"key":"2026093006132535600_aamag396-B19","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1038\/nprot.2017.107","article-title":"Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment","volume":"12","author":"Kaukonen","year":"2017","journal-title":"Nat Protoc"},{"key":"2026093006132535600_aamag396-B20","doi-asserted-by":"publisher","first-page":"100079","DOI":"10.1016\/j.mcpro.2021.100079","article-title":"Evaluation and refinement of sample preparation methods for extracellular matrix proteome coverage","volume":"20","author":"McCabe","year":"2021","journal-title":"Mol Cell Proteomics"},{"key":"2026093006132535600_aamag396-B21","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1021\/acs.jproteome.4c00810","article-title":"ECM-focused proteomic analysis of ear punch regeneration in Acomys cahirinus","volume":"24","author":"McCabe","year":"2025","journal-title":"J Proteome Res"},{"key":"2026093006132535600_aamag396-B22","doi-asserted-by":"publisher","first-page":"D1136","DOI":"10.1093\/nar\/gkz849","article-title":"MatrisomeDB: the ECM-protein knowledge database","volume":"48","author":"Shao","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2026093006132535600_aamag396-B23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.matbio.2015.06.003","article-title":"The extracellular matrix: tools and insights for the \u201comics\u201d era","volume":"49","author":"Naba","year":"2016","journal-title":"Matrix Biol"},{"key":"2026093006132535600_aamag396-B24","doi-asserted-by":"publisher","first-page":"D1519","DOI":"10.1093\/nar\/gkac1009","article-title":"MatrisomeDB 2.0: 2023 updates to the ECM-protein knowledge database","volume":"51","author":"Shao","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2026093006132535600_aamag396-B25","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1186\/1471-2105-13-S16-S12","article-title":"1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data","volume":"13(Suppl 16)","author":"Cox","year":"2012","journal-title":"BMC Bioinform"},{"key":"2026093006132535600_aamag396-B26","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1021\/acs.jproteome.8b00927","article-title":"A network module for the Perseus software for computational proteomics facilitates proteome interaction graph analysis","volume":"18","author":"Rudolph","year":"2019","journal-title":"J Proteome Res"},{"key":"2026093006132535600_aamag396-B27","doi-asserted-by":"publisher","first-page":"10259","DOI":"10.1038\/ncomms10259","article-title":"Proteomic maps of breast cancer subtypes","volume":"7","author":"Tyanova","year":"2016","journal-title":"Nat Commun"},{"key":"2026093006132535600_aamag396-B28","first-page":"133","volume-title":"Methods Mol Biol","author":"Tyanova","year":"2018"},{"key":"2026093006132535600_aamag396-B29","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1038\/nprot.2016.136","article-title":"The MaxQuant computational platform for mass spectrometry-based shotgun proteomics","volume":"11","author":"Tyanova","year":"2016","journal-title":"Nat Protoc"},{"key":"2026093006132535600_aamag396-B30","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat Methods"},{"key":"2026093006132535600_aamag396-B31","doi-asserted-by":"publisher","first-page":"20560","DOI":"10.1038\/s41598-020-76603-3","article-title":"VolcaNoseR is a web app for creating, exploring, labeling and sharing volcano plots","volume":"10","author":"Goedhart","year":"2020","journal-title":"Sci Rep"},{"key":"2026093006132535600_aamag396-B32","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2026093006132535600_aamag396-B33","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1165\/rcmb.2021-0428OC","article-title":"Screening for inhibitors of YAP nuclear localization identifies aurora kinase a as a modulator of lung fibrosis","volume":"67","author":"Yang","year":"2022","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026093006132535600_aamag396-B34","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/s41586-024-07660-1","article-title":"Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis","volume":"631","author":"Tsukui","year":"2024","journal-title":"Nature"},{"key":"2026093006132535600_aamag396-B35","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/j.ard.2025.05.016","article-title":"Matrix stiffness regulates profibrotic fibroblast differentiation and fibrotic niche activation in systemic sclerosis","volume":"84","author":"Ueberall","year":"2025","journal-title":"Ann Rheum Dis"},{"key":"2026093006132535600_aamag396-B36","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/s41467-023-44645-6","article-title":"Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis","volume":"15","author":"Ma","year":"2024","journal-title":"Nat Commun"},{"key":"2026093006132535600_aamag396-B37","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1164\/ajrccm.163.3.2006084","article-title":"Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin","volume":"163","author":"Kolb","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2026093006132535600_aamag396-B38","doi-asserted-by":"crossref","first-page":"M111.014647","DOI":"10.1074\/mcp.M111.014647","article-title":"The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices","volume":"11","author":"Naba","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"2026093006132535600_aamag396-B39","doi-asserted-by":"publisher","first-page":"643178","DOI":"10.3389\/fmolb.2021.643178","article-title":"In vivo N-terminomics highlights novel functions of ADAMTS2 and ADAMTS14 in skin collagen matrix building","volume":"8","author":"Leduc","year":"2021","journal-title":"Front Mol Biosci"},{"key":"2026093006132535600_aamag396-B40","doi-asserted-by":"publisher","first-page":"7833","DOI":"10.1021\/acs.chemrev.9b00019","article-title":"Brillouin light scattering: applications in biomedical sciences","volume":"119","author":"Palombo","year":"2019","journal-title":"Chem Rev"},{"key":"2026093006132535600_aamag396-B41","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-023-00286-z","article-title":"Brillouin microscopy","volume":"4","author":"Kabakova","year":"2024","journal-title":"Nat Rev Methods Primers"},{"key":"2026093006132535600_aamag396-B42","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/s41598-023-28536-w","article-title":"Artificial neural network identified the significant genes to distinguish idiopathic pulmonary fibrosis","volume":"13","author":"Li","year":"2023","journal-title":"Sci Rep"},{"key":"2026093006132535600_aamag396-B43","doi-asserted-by":"publisher","first-page":"4096","DOI":"10.1242\/jcs.091363","article-title":"Collagen V is a dominant regulator of collagen fibrillogenesis: dysfunctional regulation of structure and function in a corneal-stroma-specific Col5a1-null mouse model","volume":"124","author":"Sun","year":"2011","journal-title":"J Cell Sci"},{"key":"2026093006132535600_aamag396-B44","doi-asserted-by":"publisher","first-page":"53331","DOI":"10.1074\/jbc.M409622200","article-title":"Type V collagen controls the initiation of collagen fibril assembly","volume":"279","author":"Wenstrup","year":"2004","journal-title":"J Biol Chem"},{"key":"2026093006132535600_aamag396-B45","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1002\/ar.23330","article-title":"Type V collagen in health, disease, and fibrosis","volume":"299","author":"Mak","year":"2016","journal-title":"Anat Rec (Hoboken)"},{"key":"2026093006132535600_aamag396-B46","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/1357-2725(95)00047-s","article-title":"Immunoquantification of type I, III, IV and V collagen in small samples of human lung parenchyma","volume":"27","author":"van Kuppevelt","year":"1995","journal-title":"Int J Biochem Cell Biol"},{"key":"2026093006132535600_aamag396-B47","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.ceb.2008.06.008","article-title":"Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators","volume":"20","author":"Kadler","year":"2008","journal-title":"Curr Opin Cell Biol"},{"key":"2026093006132535600_aamag396-B48","doi-asserted-by":"publisher","first-page":"12888","DOI":"10.1074\/jbc.M511528200","article-title":"Murine model of the Ehlers-Danlos syndrome: col5a1 haploinsufficiency disrupts collagen fibril assembly at multiple stages","volume":"281","author":"Wenstrup","year":"2006","journal-title":"J Biol Chem"},{"key":"2026093006132535600_aamag396-B49","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.1021\/bm200553x","article-title":"Rheology of heterotypic collagen networks","volume":"12","author":"Piechocka","year":"2011","journal-title":"Biomacromolecules"},{"key":"2026093006132535600_aamag396-B50","doi-asserted-by":"publisher","first-page":"1549277","DOI":"10.3389\/fimmu.2025.1549277","article-title":"PI3K\/Akt in IPF: untangling fibrosis and charting therapies","volume":"16","author":"Bhatt","year":"2025","journal-title":"Front Immunol"},{"key":"2026093006132535600_aamag396-B51","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.apsb.2021.07.023","article-title":"Targeting PI3K\/AKT signaling for treatment of idiopathic pulmonary fibrosis","volume":"12","author":"Wang","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"2026093006132535600_aamag396-B52","doi-asserted-by":"publisher","first-page":"1801992","DOI":"10.1183\/13993003.01992-2018","article-title":"A randomised, placebo-controlled study of omipalisib (PI3K\/mTOR) in idiopathic pulmonary fibrosis","volume":"53","author":"Lukey","year":"2019","journal-title":"Eur Respir J"},{"key":"2026093006132535600_aamag396-B53","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25063178","article-title":"PI3K\/Akt\/mTOR signaling pathway as a target for colorectal cancer treatment","volume":"25","author":"Leiphrakpam","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026093006132535600_aamag396-B54","doi-asserted-by":"publisher","first-page":"1595523","DOI":"10.3389\/fonc.2025.1595523","article-title":"FN1 from cancer-associated fibroblasts orchestrates pancreatic cancer metastasis via integrin-PI3K\/AKT signaling","volume":"15","author":"Zhu","year":"2025","journal-title":"Front Oncol"},{"key":"2026093006132535600_aamag396-B55","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1111\/1759-7714.13328","article-title":"Targeting the PI3K\/Akt\/mTOR pathway in non-small cell lung cancer (NSCLC)","volume":"11","author":"Tan","year":"2020","journal-title":"Thorac Cancer"},{"key":"2026093006132535600_aamag396-B56","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.ceb.2008.10.001","article-title":"The Hippo-YAP pathway: new connections between regulation of organ size and cancer","volume":"20","author":"Zhao","year":"2008","journal-title":"Curr Opin Cell Biol"},{"key":"2026093006132535600_aamag396-B57","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1136\/ard-2023-224129","article-title":"Ablation of integrin-mediated cell-collagen communication alleviates fibrosis","volume":"82","author":"Sawant","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"2026093006132535600_aamag396-B58","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1096\/fj.15-279869","article-title":"Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-\u03b2 signaling as primary targets","volume":"30","author":"Bekhouche","year":"2016","journal-title":"FASEB J"},{"key":"2026093006132535600_aamag396-B59","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/path.6214","article-title":"Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function","volume":"262","author":"Carter","year":"2024","journal-title":"J Pathol"},{"key":"2026093006132535600_aamag396-B60","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.1681\/ASN.2015050499","article-title":"YAP\/TAZ are mechanoregulators of TGF-\u03b2-Smad signaling and renal fibrogenesis","volume":"27","author":"Szeto","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"2026093006132535600_aamag396-B61","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1167\/iovs.18-24258","article-title":"YAP\/TAZ are essential for TGF-\u03b22-mediated conjunctival fibrosis","volume":"59","author":"Futakuchi","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2026093006132535600_aamag396-B62","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1242\/dev.02308","article-title":"Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis","volume":"133","author":"Le Goff","year":"2006","journal-title":"Development"},{"key":"2026093006132535600_aamag396-B63","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.matbio.2018.04.002","article-title":"Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14","volume":"70","author":"Dupont","year":"2018","journal-title":"Matrix Biol"},{"key":"2026093006132535600_aamag396-B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2026.05.034","article-title":"Fibroblast-specific deletion of Yap\/Taz impairs mouse postnatal dermal development by diminishing collagenous matrix [published online ahead of print June 18, 2026]","author":"Ermilov","journal-title":"J Invest Dermatol"},{"key":"2026093006132535600_aamag396-B65","doi-asserted-by":"publisher","first-page":"135","DOI":"10.5021\/ad.23.156","article-title":"Emerging perspectives of YAP\/TAZ in human skin epidermal and dermal aging","volume":"36","author":"Kim","year":"2024","journal-title":"Ann Dermatol"},{"key":"2026093006132535600_aamag396-B66","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/s41586-022-04924-6","article-title":"YAP\/TAZ activity in stromal cells prevents ageing by controlling cGAS\u2013STING","volume":"607","author":"Sladitschek-Martens","year":"2022","journal-title":"Nature"},{"key":"2026093006132535600_aamag396-B67","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.173374","article-title":"Epithelial Yap\/Taz are required for functional alveolar regeneration following acute lung injury","volume":"8","author":"DiGiovanni","year":"2023","journal-title":"JCI Insight"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article-pdf\/doi\/10.1093\/ajrccm\/aamag396\/70274397\/aamag396.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/10\/2386\/70274397\/aamag396.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/10\/2386\/70274397\/aamag396.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:13:35Z","timestamp":1790763215000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/212\/10\/2386\/8745968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":67,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,7,28]]},"published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajrccm\/aamag396","relation":{},"ISSN":["1535-4970"],"issn-type":[{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,7,28]]}}}