{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:33:00Z","timestamp":1793370780233,"version":"4.5.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,1]]},"DOI":"10.1093\/ajrccm\/aamag449","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:54:09Z","timestamp":1788616449000},"page":"2709-2712","source":"Crossref","is-referenced-by-count":0,"title":["Phenotypes of all isogenic mice with pneumococcal pneumonia are equal, or are they?"],"prefix":"10.1093","volume":"212","author":[{"given":"Dario","family":"von Wedel","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin,","place":["Germany"]},{"name":"Institute of Medical Informatics, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9787-5633","authenticated-orcid":false,"given":"Martin","family":"Witzenrath","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin,","place":["Germany"]},{"name":"German Center for Lung Research (DZL) , Berlin,","place":["Germany"]},{"name":"CAPNETZ Foundation , Hannover,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"2026103009495890900_aamag449-B1","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S2213-2600(14)70097-9","article-title":"Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials","volume":"2","author":"Calfee","year":"2014","journal-title":"Lancet Respir Med"},{"key":"2026103009495890900_aamag449-B2","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/S2213-2600(23)00237-0","article-title":"Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials","volume":"11","author":"Sinha","year":"2023","journal-title":"Lancet Respir Med"},{"key":"2026103009495890900_aamag449-B3","doi-asserted-by":"publisher","first-page":"e197346","DOI":"10.1172\/JCI197346","article-title":"Pathogen characteristics are key determinants of distinct host response phenotypes of sepsis","volume":"136","author":"Chanderraj","year":"2026","journal-title":"J Clin Invest"},{"key":"2026103009495890900_aamag449-B4","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1007\/s00134-023-07244-z","article-title":"Inflammatory subphenotypes in patients at risk of ARDS: evidence from the LIPS-A trial","volume":"49","author":"Redaelli","year":"2023","journal-title":"Intensive Care Med"},{"key":"2026103009495890900_aamag449-B5","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S2213-2600(18)30177-2","article-title":"Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial","volume":"6","author":"Calfee","year":"2018","journal-title":"Lancet Respir Med"},{"key":"2026103009495890900_aamag449-B6","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1007\/s00134-025-08089-4","article-title":"Temporal stability of phenotypes of acute respiratory distress syndrome: clinical implications for early corticosteroid therapy and mortality","volume":"51","author":"Pensier","year":"2025","journal-title":"Intensive Care Med"},{"key":"2026103009495890900_aamag449-B7","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s13054-024-04959-3","article-title":"Biological basis of critical illness subclasses: from the bedside to the bench and back again","volume":"28","author":"Stevens","year":"2024","journal-title":"Crit Care"},{"key":"2026103009495890900_aamag449-B8","doi-asserted-by":"publisher","first-page":"aamag402","DOI":"10.1093\/ajrccm\/aamag402","article-title":"Inflammatory phenotypes in severe pneumonia: clinical evidence to mouse models for precision therapeutics","author":"Taenaka","year":"2026","journal-title":"Am J Respir Crit Care Med"},{"key":"2026103009495890900_aamag449-B9","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1073\/pnas.1222878110","article-title":"Genomic responses in mouse models poorly mimic human inflammatory diseases","volume":"110","author":"Seok","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026103009495890900_aamag449-B10","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1073\/pnas.1401965111","article-title":"Genomic responses in mouse models greatly mimic human inflammatory diseases","volume":"112","author":"Takao","year":"2015","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026103009495890900_aamag449-B11","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1164\/rccm.202406-1241OC","article-title":"Temporal transitions of the hyperinflammatory and hypoinflammatory phenotypes in critical illness","volume":"211","author":"van Amstel","year":"2025","journal-title":"Am J Respir Crit Care Med"},{"key":"2026103009495890900_aamag449-B12","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1164\/rccm.202308-1328OC","article-title":"Host and microbe blood metagenomics reveals key pathways characterizing critical illness phenotypes","volume":"209","author":"Neyton","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"2026103009495890900_aamag449-B13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13054-020-03427-y","article-title":"Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS","volume":"25","author":"Bendib","year":"2021","journal-title":"Crit Care"},{"key":"2026103009495890900_aamag449-B14","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/S2213-2600(26)00045-7","article-title":"Effects of inflammatory phenotypes in acute respiratory distress syndrome on mortality and partitioning of lung and chest wall mechanics in patients in the USA and Canada: a retrospective cohort study","volume":"14","author":"Pensier","year":"2026","journal-title":"Lancet Respir Med"},{"key":"2026103009495890900_aamag449-B15","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1164\/rccm.201711-2180OC","article-title":"The lung microbiota of healthy mice are highly variable, cluster by environment, and reflect variation in baseline lung innate immunity","volume":"198","author":"Dickson","year":"2018","journal-title":"Am J Respir Crit Care Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article-pdf\/doi\/10.1093\/ajrccm\/aamag449\/70994191\/aamag449.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/11\/2709\/70994191\/aamag449.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/11\/2709\/70994191\/aamag449.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:50:06Z","timestamp":1793368206000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/212\/11\/2709\/8787911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":15,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,9,8]]},"published-print":{"date-parts":[[2026,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajrccm\/aamag449","relation":{},"ISSN":["1535-4970"],"issn-type":[{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,11]]},"published":{"date-parts":[[2026,9,8]]}}}