{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:00:11Z","timestamp":1790341211500,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Intermediate endpoints that predict lung function decline are needed to improve the efficiency of clinical trials in chronic obstructive pulmonary disease (COPD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To test if one-year progression of quantitative computed tomography (QCT) measures predicts subsequent FEV\u2081 decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SPIROMICS recruited individuals with \u2265 20 pack-years smoking history with or without COPD and nonsmoking controls who underwent four annual and a later fifth visit. We analyzed chest CT scans at visits one and two for machine-learned CT emphysema subtypes (combined bronchitic-apical emphysema [CBaE], diffuse emphysema) and standard QCT measures of emphysema (percent emphysema-950HU, 15th percentile HU, volume-adjusted lung density), airways, functional small airways, hyperinflation, parenchymal texture and vasculature. Linear mixed-effects models evaluated associations between one-year QCT measure changes and FEV\u2081 decline from visits two through five, adjusting for demographics, site, enrollment group, baseline QCT value, and time-varying anthropometrics and smoking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Among 880 participants (43% mild\/moderate COPD, 17% severe COPD, 29% smoking controls, 11% nonsmoking controls), FEV\u2081 declined -30.4mL\/year (95% CI: -34.5, -26.3). A standard deviation (SD) one-year increase in CBaE and diffuse emphysema predicted an accelerated decline in FEV1 of\u2009\u2212\u20094.2\u2009mL\/year (95% CI: \u22128.3, \u22120.2) and \u22126.2\u2009mL\/year (95% CI: \u221210.7, \u22121.8), respectively. Changes in standard QCT emphysema measures also predicted change in FEV1 decline, but only CBaE and diffuse emphysema remained independently predictive of accelerated FEV1 decline when all were considered together.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>One-year progression of CT emphysema subtypes predicted accelerated FEV\u2081 decline, supporting their potential use as intermediate endpoints in COPD trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajrccm\/aamag497","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:28:13Z","timestamp":1790335693000},"source":"Crossref","is-referenced-by-count":0,"title":["One-year progression of CT emphysema subtypes predict lung function decline: SPIROMICS"],"prefix":"10.1093","author":[{"given":"Emilia A","family":"Hermann","sequence":"first","affiliation":[{"name":"Columbia University Irving Medical Center Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A","family":"Hoffman","sequence":"additional","affiliation":[{"name":"University of Iowa Carver College of Medicine Department of Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa D","family":"Angelini","sequence":"additional","affiliation":[{"name":"T\u00e9l\u00e9com Paris, Institut Polytechnique de Paris"},{"name":"Columbia University Department of Biomedical Engineering,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Barjaktarevic","sequence":"additional","affiliation":[{"name":"University of California Los Angeles Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Bon","sequence":"additional","affiliation":[{"name":"Wake Forest University Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy, and Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Comellas","sequence":"additional","affiliation":[{"name":"University of Iowa Carver College of Medicine Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B","family":"Cooper","sequence":"additional","affiliation":[{"name":"University of California Los Angeles Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Couper","sequence":"additional","affiliation":[{"name":"University of North Carolina Gillings School of Global Public Health Department of Biostatistics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L","family":"Curtis","sequence":"additional","affiliation":[{"name":"University of Michigan Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Criner","sequence":"additional","affiliation":[{"name":"Lewis Katz School of Medicine at Temple University Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Michael","family":"Wells","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Robert","family":"Paine","sequence":"additional","affiliation":[{"name":"University of Utah Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry A","family":"Krishnan","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Labaki","sequence":"additional","affiliation":[{"name":"University of Michigan Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F","family":"Laine","sequence":"additional","affiliation":[{"name":"Columbia University Department of Biomedical Engineering,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Lynch","sequence":"additional","affiliation":[{"name":"National Jewish Health Department of Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MeiLan K","family":"Han","sequence":"additional","affiliation":[{"name":"University of Michigan Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia N","family":"Hansel","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Medicine Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando J","family":"Martinez","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College Department of Medicine, Division of Pulmonary and Critical Care Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Ortega","sequence":"additional","affiliation":[{"name":"Mayo Clinic Department of Pulmonary Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Smith","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Sun","sequence":"additional","affiliation":[{"name":"Columbia University Department of Biostatistics, Mailman School of Public Health,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prescott","family":"Woodruff","sequence":"additional","affiliation":[{"name":"University of California San Francisco Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Graham","family":"Barr","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center Department of Medicine,"},{"name":"Columbia University Irving Medical Center Department of Epidemiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,25]]},"container-title":["American Journal of Respiratory and Critical Care 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