{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:56:17Z","timestamp":1790740577733,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Interstitial lung abnormalities (ILA) are common, but not all progress, highlighting the need for objective computed tomography (CT)-based biomarkers for risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether deep learning-based classification of usual interstitial pneumonia (UIP) is associated with fibrosis progression and survival in individuals with ILA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Baseline and follow-up CT scans from participants without clinically diagnosed interstitial lung disease in two large observational cohorts (COPDGene and AGES-Reykjav\u00edk) were analyzed using data-driven textural analysis (DTA) to quantify fibrosis and a deep learning-based classifier (MIL-UIP) to estimate UIP likelihood. Associations of baseline MIL-UIP with DTA trajectory and survival were evaluated using linear mixed and multivariable Cox models, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Baseline MIL-UIP &amp;gt; 0.5 was associated with relative annual DTA increases of 13.41% (95% CI: 8.10%, 18.99%; p\u2009&amp;lt;\u20090.001) and 14.10% (95% CI: 5.06%, 23.91%; p\u2009=\u20090.002) in COPDGene and AGES-Reykjav\u00edk, respectively. Each 0.1-point increase in MIL-UIP was associated with relative rates of DTA change that were 1.10 percentage points higher (95% CI: 0.45, 1.74; p\u2009&amp;lt;\u20090.001) in COPDGene and 1.30 percentage points higher (95% CI: 0.17, 2.45; p\u2009=\u20090.025) in AGES-Reykjav\u00edk. MIL-UIP &amp;gt; 0.5 was associated with higher mortality in COPDGene (HR 1.61; 95% CI: 1.08, 2.38; p\u2009=\u20090.018) and AGES-Reykjav\u00edk (HR 1.62; 95% CI: 1.01, 2.61; p\u2009=\u20090.046). Baseline DTA and MIL-UIP were highly associated with visual assessments of ILA, UIP, and fibrosis progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Automated assessment of UIP-like CT features is associated with fibrosis progression and mortality in individuals with ILA, supporting its potential use for risk stratification and clinical trials enrichment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajrccm\/aamag525","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:34:11Z","timestamp":1790681651000},"source":"Crossref","is-referenced-by-count":0,"title":["Deep learning classification of radiologic pattern is associated with progression of interstitial lung abnormalities and with survival"],"prefix":"10.1093","author":[{"given":"David","family":"Baraghoshi","sequence":"first","affiliation":[{"name":"National Jewish Health Division of Biostatistics, , Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devlin","family":"Thieke","sequence":"additional","affiliation":[{"name":"National Jewish Health Department of Radiology, , Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Hatabu","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Department of Radiology, , Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M","family":"Hunninghake","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital Division of Pulmonary and Critical Care Medicine, , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Rose","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital Division of Pulmonary and Critical Care Medicine, , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Putman","sequence":"additional","affiliation":[{"name":"Warren Alpert Medical School Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, , Providence, RI"},{"name":"Brown University Health Center for Advanced Lung Care, , Providence, RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Gudmundsson","sequence":"additional","affiliation":[{"name":"Landspitali University Hospital Department of Respiratory Medicine, , and Faculty of Medicine, , Reykjav\u00edk,","place":["Iceland"]},{"name":"University of Iceland Department of Respiratory Medicine, , and Faculty of Medicine, , Reykjav\u00edk,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilmundur","family":"Gudnason","sequence":"additional","affiliation":[{"name":"Icelandic Heart Association , Kopavogur,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J","family":"Solomon","sequence":"additional","affiliation":[{"name":"National Jewish Health Center for Interstitial Lung Disease, , Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soonho","family":"Yoon","sequence":"additional","affiliation":[{"name":"National Jewish Health Department of Radiology, , Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Lynch","sequence":"additional","affiliation":[{"name":"National Jewish Health Department of Radiology, , Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M","family":"Humphries","sequence":"additional","affiliation":[{"name":"National Jewish Health Department of Radiology, , Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,29]]},"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article-pdf\/doi\/10.1093\/ajrccm\/aamag525\/71476219\/aamag525.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article-pdf\/doi\/10.1093\/ajrccm\/aamag525\/71476219\/aamag525.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:08:51Z","timestamp":1790737731000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/advance-article\/doi\/10.1093\/ajrccm\/aamag525\/8847222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ajrccm\/aamag525","relation":{},"ISSN":["1535-4970"],"issn-type":[{"value":"1535-4970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"article-number":"aamag525"}}