{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T01:26:14Z","timestamp":1794619574570,"version":"4.9.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pulmonary blood volumes (PBV), currently not assessed by computed tomography pulmonary angiography (CTPA), could provide additional information to routine investigations performed for chronic thromboembolic pulmonary hypertension (CTEPH). We investigated CTPA-based PBV in evaluating hemodynamic outcome from pulmonary endarterectomy (PEA) surgery. A deep learning-based CTPA vascular segmentation model, differentiating arteries and veins, was applied for automated PBV measurements in CTEPH patients who underwent PEA at U.K.\u2019s national CTEPH service. Pulmonary arteries were compartmentalised into \u201ccentral\u201d (main pulmonary and proximal lobar) and \u201cintrapulmonary\u201d. Mean pulmonary arterial pressure\u2009&amp;gt;30\u2009mmHg post-PEA defined \u201cclinically relevant\u201d residual PH. Logistic regression models applying CTPA-based PBV to identify residual PH were trained and tested on the discovery and validation cohorts respectively. Paired pre- and postoperative CTPA, in the discovery (n\u2009=\u200971) and validation (n\u2009=\u2009102) cohorts showed that central pulmonary artery volume and total artery to vein volume ratio (A-VR) decreased and pulmonary vein volume increased with hemodynamic improvement post-PEA. Preoperative central pulmonary artery volume and A-VR helped identify patients at risk for clinically relevant residual PH post-PEA (AUROC 0.88 and 0.82 in the discovery and validation cohorts). Postoperative central pulmonary artery volume, A-VR and pulmonary vein volume helped to non-invasively identify patients without clinically relevant residual PH (AUROC 0.91 and 0.88 in the discovery and validation cohorts). Automated quantification of CTPA-based PBV at diagnosis can help stratify risk for residual PH in patients managed with PEA. Utilizing CTPA-derived PBV post-PEA to identify patients without residual PH can potentially reduce the need for routine postoperative right heart catheterization.<\/jats:p>","DOI":"10.1093\/ajrcmb\/aanaf026","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:36:42Z","timestamp":1778002602000},"page":"e1-e39","source":"Crossref","is-referenced-by-count":1,"title":["Withdrawn as duplicate: Pulmonary Blood Volumes on CT Predict Residual Pulmonary Hypertension Post-Pulmonary Endarterectomy"],"prefix":"10.1093","volume":"74","author":[{"given":"Hakim","family":"Ghani","sequence":"first","affiliation":[{"name":"National Pulmonary Hypertension Centre, Pulmonary Vascular Disease Unit, Royal Papworth Hospital , Cambridge,","place":["United Kingdom"]},{"name":"University of Cambridge ,","place":["United 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Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Walsh","sequence":"additional","affiliation":[{"name":"Qureight Ltd , Cambridge,","place":["United Kingdom"]},{"name":"National Heart and Lung Institute, Imperial College , London,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Screaton","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Radiology Department, , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Bunclark","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Centre, Pulmonary Vascular Disease Unit, Royal Papworth Hospital , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Cannon","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Centre, Pulmonary Vascular Disease Unit, Royal Papworth Hospital , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Sheares","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Centre, Pulmonary Vascular Disease Unit, Royal Papworth Hospital , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Taboada","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Centre, Pulmonary Vascular Disease Unit, Royal Papworth Hospital , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Graves","sequence":"additional","affiliation":[{"name":"University of Cambridge ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Toshner","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Centre, Pulmonary Vascular Disease Unit, Royal Papworth Hospital , Cambridge,","place":["United Kingdom"]},{"name":"University of Cambridge ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choo","family":"Ng","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital Department of Cardiothoracic Surgery, , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Pepke-Zaba","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Centre, Pulmonary Vascular Disease Unit, Royal Papworth Hospital , Cambridge,","place":["United Kingdom"]},{"name":"University of Cambridge ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,22]]},"container-title":["American Journal of Respiratory Cell and Molecular 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