{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:01:28Z","timestamp":1785250888847,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The lung is a highly dynamic organ that depends on adaptable protein translation to maintain homeostasis during mechanical, metabolic, and infectious stress. Transcriptomic studies have mapped disease\u2011associated changes in mRNA expression across diverse lung disorders, but standard RNA\u2011sequencing approaches largely overlook transfer RNAs (tRNAs), obscuring an important layer of translational control. Recent advances in tRNA\u2011focused sequencing and functional studies have reframed tRNAs from passive adaptors to active regulators of lung biology. In this mini\u2011review, we highlight three major regulatory axes of tRNA biology\u2013aminoacyl\u2011tRNA charging, tRNA methylation, and tRNA\u2011derived fragments\u2013and their emerging roles in lung injury, infection, and cancer. We discuss how altered tRNA charging in anti-synthetase syndrome and stress response pathways, dysregulated tRNA methylation in lung cancer, and stress\u2011induced tRNA fragments that signal through pattern\u2011recognition receptors or Argonaute complexes converge on pathways controlling inflammation, remodeling, and cell survival. Finally, we outline current technical barriers to capturing tRNA species in lung omics and propose opportunities to integrate tRNA biology in future mechanistic and translational research.<\/jats:p>","DOI":"10.1093\/ajrcmb\/aanag151","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:20:31Z","timestamp":1785151231000},"source":"Crossref","is-referenced-by-count":0,"title":["Lost in Translation: tRNAs emerge as active regulators in lung disease"],"prefix":"10.1093","author":[{"given":"Moemen","family":"Eltobgy","sequence":"first","affiliation":[{"name":"The Ohio State University Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, , Columbus, OH,","place":["United States"]},{"name":"The Ohio State University Dorothy M. Davis Heart and Lung Research Institute (DHLRI), College of Medicine, , Columbus, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Segreto","sequence":"additional","affiliation":[{"name":"The Ohio State University Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, , Columbus, OH,","place":["United States"]},{"name":"The Ohio State University Dorothy M. Davis Heart and Lung Research Institute (DHLRI), College of Medicine, , Columbus, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama K","family":"Mallampalli","sequence":"additional","affiliation":[{"name":"The Ohio State University Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, , Columbus, OH,","place":["United States"]},{"name":"The Ohio State University Dorothy M. Davis Heart and Lung Research Institute (DHLRI), College of Medicine, , Columbus, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S","family":"Bednash","sequence":"additional","affiliation":[{"name":"The Ohio State University Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, , Columbus, OH,","place":["United States"]},{"name":"The Ohio State University Dorothy M. Davis Heart and Lung Research Institute (DHLRI), College of Medicine, , Columbus, OH,","place":["United States"]},{"name":"The Ohio State University The Center for RNA Biology, College of Medicine, , Columbus, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,28]]},"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/advance-article-pdf\/doi\/10.1093\/ajrcmb\/aanag151\/70263835\/aanag151.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/advance-article-pdf\/doi\/10.1093\/ajrcmb\/aanag151\/70263835\/aanag151.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:38:11Z","timestamp":1785249491000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/advance-article\/doi\/10.1093\/ajrcmb\/aanag151\/8744087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ajrcmb\/aanag151","relation":{},"ISSN":["1535-4989"],"issn-type":[{"value":"1535-4989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"article-number":"aanag151"}}