{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T23:57:50Z","timestamp":1701561470074},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Treatment with saikosaponin A (SSA)\u2014an ingredient of the medicinal herb, Bupleurum falcatum\u2014has been reported to suppress several addictive-like behaviors, including morphine, cocaine, alcohol and chocolate self-administration in male rats. The aim of this investigation was to investigate whether saikosaponins of B. falcatum other than SSA affect alcohol and chocolate self-administration in rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Ovariectomized female Sardinian alcohol-preferring (sP) and Wistar rats were trained to self-administer alcohol (15%, v\/v) and a chocolate solution [5% (w\/v) Nesquik\u00ae in water], respectively, under fixed ratio schedules of reinforcement. The following saikosaponins were compared to SSA: saikosaponin D (SSD; epimer of SSA), saikosaponin C (SSC), saikosaponin B2 (SSB2) and saikosaponin B4 (SSB4). All saikosaponins were tested acutely at the doses of 0, 0.25, 0.5 and 1\u00a0mg\/kg (i.p.).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Treatment with SSA and SSD resulted in highly similar, marked reductions in alcohol self-administration; SSC failed to alter lever-responding for alcohol, while SSB2 and SSB4 produced intermediate reductions. Only SSA and SSD reduced chocolate self-administration, with SSC, SSB2 and SSB4 being ineffective.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The wide spectrum of efficacy of saikosaponins in reducing alcohol and chocolate self-administration suggests that even relatively small structural differences are sufficient to produce remarkable changes in their in vivo pharmacological profile. Together, these results confirm that roots of B. falcatum may be an interesting source of compounds with anti-addictive potential.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agaa049","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T11:15:08Z","timestamp":1588763708000},"page":"367-373","source":"Crossref","is-referenced-by-count":4,"title":["Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats"],"prefix":"10.1093","volume":"55","author":[{"given":"Paola","family":"Maccioni","sequence":"first","affiliation":[{"name":"Neuroscience Institute, Section of Cagliari, National Research Council of Italy, Monserrato (CA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Lorrai","sequence":"first","affiliation":[{"name":"Neuroscience Institute, Section of Cagliari, National Research Council of Italy, Monserrato (CA), Italy"},{"name":"Department 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