{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:20:30Z","timestamp":1779290430324,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T00:00:00Z","timestamp":1592006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970715"],"award-info":[{"award-number":["81970715"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770815"],"award-info":[{"award-number":["81770815"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Sichuan Province","award":["2019YFS0222"],"award-info":[{"award-number":["2019YFS0222"]}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["2018SCUH0065"],"award-info":[{"award-number":["2018SCUH0065"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYGD18014"],"award-info":[{"award-number":["ZYGD18014"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009564","name":"Health and Family Planning Commission of Sichuan Province","doi-asserted-by":"publisher","award":["18PJ158"],"award-info":[{"award-number":["18PJ158"]}],"id":[{"id":"10.13039\/501100009564","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Innovation and Entrepreneurship Project of Sichuan Province","award":["2018RZ0135"],"award-info":[{"award-number":["2018RZ0135"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Alcohol intake is a risk factor for cardiovascular diseases. This study was designed to investigate whether chronic alcohol intake affects myocardial infarction (MI)-induced cardiac remodeling and heart failure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Eight-week-old male C57BL\/6 mice were randomly divided into four groups: Sham group (Sham), MI plus drinking water group (MI\u00a0+\u00a0Vehicle), and MI plus daily alcohol intake for 6\u00a0weeks with or without gavage of additional alcohol every 3\u00a0days (MI\u00a0+\u00a0Alcohol and MI\u00a0+\u00a0Alcohol\u00a0+\u00a0G). The MI were induced by permanent left anterior descending (LAD) coronary artery ligation surgery before vehicle or alcohol treatment. The blood alcohol concentration (BAC), cardiac function, release of cardiac enzymes, pathological changes and mitochondrial function were measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>As expected, supplementation of alcohol in drinking water significantly increased random BAC in mice. Long-term exposure to alcohol further reduced body weight, ejection fraction and fractional shortening in comparison with the MI\u00a0+\u00a0Vehicle group. Histopathological data showed that alcohol increased fibrosis in infarct zone, which was well correlated with the functional decline. Also, as compared to the MI\u00a0+\u00a0Vehicle group, the adenosine diphosphate-supported respiratory function of freshly isolated cardiac mitochondria was inhibited in the MI\u00a0+\u00a0Alcohol\u00a0+\u00a0G group. Besides, upon MI-induced cardiac damage, we did not observe further changes in heart weight, cardiomyocyte enlargement in remote zone, exercise capacity, lung edema and the release of cardiac enzyme after chronic alcohol intake.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study demonstrated that chronic daily alcohol exposure exacerbated MI-induced cardiac dysfunction, which is related to promoted myocardial fibrosis and inhibited mitochondrial function.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agaa055","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T11:06:39Z","timestamp":1590404799000},"page":"524-530","source":"Crossref","is-referenced-by-count":8,"title":["Chronic Alcohol Intake Exacerbates Cardiac Dysfunction After Myocardial Infarction"],"prefix":"10.1093","volume":"55","author":[{"given":"Yu","family":"Liang","sequence":"first","affiliation":[{"name":"Laboratory of Mitochondrial Biology and Anesthesia, West China-Washington Mitochondria and Metabolism Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, No 37 Wainan Guoxue Road, Chengdu 610041, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, West China Hospital of Sichuan University, No 37 Wainan Guoxue Road, Chengdu 610041, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Mianyang Hospital of Traditional Chinese Medicine, No 14 Fucheng Road, Mianyang 621000, PR 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Mitochondria and Metabolism Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, No 37 Wainan Guoxue Road, Chengdu 610041, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Ou","sequence":"additional","affiliation":[{"name":"Laboratory of Mitochondrial Biology and Anesthesia, West China-Washington Mitochondria and Metabolism Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, No 37 Wainan Guoxue Road, Chengdu 610041, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinqin","family":"He","sequence":"additional","affiliation":[{"name":"Laboratory of Mitochondrial Biology and Anesthesia, West China-Washington Mitochondria and Metabolism Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, No 37 Wainan Guoxue Road, Chengdu 610041, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chengdu Woman\u2019s and Children\u2019s Central Hospital, No 1617 Riyue Avenue, Chengdu 610091, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The general hospital of western theater command, No 270 Rongdu Avenue, Chengdu 610083, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Mitochondrial Biology and Anesthesia, West China-Washington Mitochondria and Metabolism Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, No 37 Wainan Guoxue Road, Chengdu 610041, PR 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