{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:19:07Z","timestamp":1789172347589,"version":"build-2803163510"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Vincent van Gogh Institute for Psychiatry"},{"name":"Nijmegen Institute for Scientist-Practitioners in Addiction"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>In patients with a history of chronic alcohol abuse, neurocognitive disorders (NCD) are not uncommon. The current study aimed to explore the course of cognitive performance, as measured by the Montreal Cognitive Assessment (MoCA), and everyday cognitive functioning, as measured by the Patient Competency Rating Scale (PCRS), in a large group of patients with alcohol use disorder (AUD) admitted to the Center of Excellence for Korsakov and Alcohol-related Cognitive Impairments.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A multiple time-series design was used, in which the MoCA was administered at three time points of assessment, and the PCRS was completed by both the patient and a clinician at two time points, all during clinical treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 524 patients were included, 71 of whom were diagnosed with AUD only, 284 with AUD and mild NCD (ARCI) and 169 with AUD, major NCD and fulfilling criteria for Korsakoff\u2019s syndrome (KS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Cognitive performance improved for all three groups during treatment, sustained abstinence and recovery from AUD. A low memory performance on the MoCA without improvement over time was predictive for KS, while improvement on this domain did not differentiate between AUD and ARCI. Changes in overall cognitive performance and orientation in patients with KS were positively related to changes in everyday cognitive functioning.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agaa100","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T19:13:32Z","timestamp":1600283612000},"page":"89-100","source":"Crossref","is-referenced-by-count":19,"title":["The Course of Cognitive Performance during Inpatient Treatment in Patients with Alcohol Use Disorder with No, Mild or Major Neurocognitive Disorders"],"prefix":"10.1093","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4133-3165","authenticated-orcid":false,"given":"C J W H","family":"Bruijnen","sequence":"first","affiliation":[{"name":"Center of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, 5800 Venray, The Netherlands"},{"name":"Nijmegen Institute for Scientist-Practitioners in Addiction (NISPA), Radboud University, 6500 Nijmegen, The Netherlands"},{"name":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6500 Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5316-6299","authenticated-orcid":false,"given":"S J W","family":"Walvoort","sequence":"additional","affiliation":[{"name":"Center of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, 5800 Venray, The Netherlands"},{"name":"Nijmegen Institute for Scientist-Practitioners in Addiction (NISPA), Radboud University, 6500 Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1467-7808","authenticated-orcid":false,"given":"B A G","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Nijmegen Institute for Scientist-Practitioners in Addiction (NISPA), Radboud University, 6500 Nijmegen, The Netherlands"},{"name":"Novadic-Kentron, Addiction Care Center, 5260 Vught, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1824-7303","authenticated-orcid":false,"given":"C A J","family":"de Jong","sequence":"additional","affiliation":[{"name":"Nijmegen Institute for Scientist-Practitioners in Addiction (NISPA), Radboud University, 6500 Nijmegen, The Netherlands"},{"name":"Behavioural Science Institute, Radboud University, 6500 Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9500-9793","authenticated-orcid":false,"given":"R P C","family":"Kessels","sequence":"additional","affiliation":[{"name":"Center of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, 5800 Venray, The Netherlands"},{"name":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6500 Nijmegen, The Netherlands"},{"name":"Department of Medical Psychology, Radboud University Medical Center, 6500 Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"2021062212493005000_ref1","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/acer.12734","article-title":"MoCA as a screening tool of neuropsychological deficits in alcohol-dependent patients","volume":"39","author":"Alarcon","year":"2015","journal-title":"Alcohol Clin Exp Res"},{"key":"2021062212493005000_ref2","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"2021062212493005000_ref3","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.2147\/NDT.S130078","article-title":"Korsakoff's syndrome: a critical 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