{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:17:06Z","timestamp":1790727426766,"version":"4.1.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institutes on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA019458"],"award-info":[{"award-number":["R01AA019458"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018786","name":"Al-Zaytoonah University, College of Pharmacy, Amman, Jordan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>Reinforcing properties of ethanol and cocaine are mediated in part through the glutamatergic system. Extracellular glutamate concentration is strictly maintained through several glutamate transporters, such as glutamate transporter 1 (GLT-1), cystine\/glutamate transporter (xCT) and glutamate aspartate transporter (GLAST). Previous findings revealed that cocaine and ethanol exposure downregulated GLT-1 and xCT, and that \u03b2-lactam antibiotics restored their expression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this study, we investigated the effect of ampicillin\/sulbactam (AMP\/SUL) (200\u00a0mg\/kg, i.p.), a \u03b2-lactam antibiotic, on cocaine-induced reinstatement and locomotor activity in male alcohol preferring (P) rats using free choice ethanol (15 and 30%, v\/v) and water. We also investigated the effect of co-exposure to ethanol and cocaine (20\u00a0mg\/kg, i.p.) on GLT-1, xCT and GLAST expression in the nucleus accumbens (NAc) core, NAc shell and dorsomedial prefrontal cortex (dmPFC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Cocaine exposure decreased ethanol intake and preference. Cocaine and ethanol co-exposure acquired place preference and increased locomotor activity compared to ethanol-exposed rats. GLT-1 and xCT expression were downregulated after cocaine and ethanol co-exposure in the NAc core and shell, but not in dmPFC. AMP\/SUL attenuated reinstatement to cocaine as well attenuated the decrease in locomotor activity and ethanol intake and preference. These effects were associated with upregulation of GLT-1 and xCT expression in the NAc core\/shell and dmPFC. GLAST expression was not affected after ethanol and cocaine co-exposure or AMP\/SUL treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings demonstrate that astrocytic glutamate transporters within the mesocorticolimbic area are critical targets in modulating cocaine-seeking behavior while being consuming ethanol.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agaa104","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T19:09:40Z","timestamp":1600542580000},"page":"210-219","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Modulation of the Astrocytic Glutamate Transporters\u2019 Expression on Cocaine-Induced Reinstatement in Male P Rats Exposed to Ethanol"],"prefix":"10.1093","volume":"56","author":[{"given":"Alaa M","family":"Hammad","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics , College of Pharmacy and Pharmaceutical Sciences, , Toledo, OH, USA"},{"name":"University of Toledo , College of Pharmacy and Pharmaceutical Sciences, , Toledo, OH, USA"},{"name":"Department of Pharmacy , , Al-Zaytoonah University of Jordan, Amman, Jordan"},{"name":"College of Pharmacy , , Al-Zaytoonah University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawaz","family":"Alasmari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics , College of Pharmacy and Pharmaceutical Sciences, , Toledo, OH, USA"},{"name":"University of Toledo , College of Pharmacy and Pharmaceutical Sciences, , Toledo, OH, USA"},{"name":"Department of Pharmacology and Toxicology , College of Pharmacy, , Riyadh, Saudi Arabia"},{"name":"King Saud University , College of Pharmacy, , Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6761-9786","authenticated-orcid":false,"given":"Youssef","family":"Sari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics , College of Pharmacy and Pharmaceutical Sciences, , Toledo, OH, USA"},{"name":"University of Toledo , College of Pharmacy and Pharmaceutical Sciences, , Toledo, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"2024041009291048000_ref1","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/jnr.23554","article-title":"Effects of (R)-(\u2212)-5-methyl-1-nicotinoyl-2-pyrazoline on glutamate transporter 1 and cysteine\/glutamate exchanger as well as ethanol drinking behavior in male, alcohol-preferring rats","volume":"93","author":"Aal-Aaboda","year":"2015","journal-title":"J Neurosci 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