{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:50:24Z","timestamp":1784202624879,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Blue Cross Lade Addiction Treatment Centre"},{"name":"Clinic of Substance Use and Addiction Medicine"},{"name":"Medical and Health Research in Central Norway","award":["2016\/45"],"award-info":[{"award-number":["2016\/45"]}]},{"name":"Norwegian Medicines Agency","award":["2015-004463-37"],"award-info":[{"award-number":["2015-004463-37"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim of this study was to assess the efficacy of self-administered intranasal oxytocin on alcohol dependence after detoxification.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a double-blind, randomized, placebo-controlled trial, 38 patients fulfilling the criteria for ICD-10 diagnosis of alcohol dependence received either 8\u00a0IU oxytocin or placebo at their own discretion up to thrice daily for 4 weeks, after completing detoxification. Primary outcome was alcohol intake specified as the amount of alcohol consumed, the number of days to relapse into alcohol use and the proportion of subjects relapsing. Secondary outcomes were self-reported symptoms of craving, sleep and mental distress.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were no significant differences between the oxytocin group and the placebo group in daily alcohol intake in total (mean 1.3 \u00b1 2.9 vs. 2.0 \u00b1 5.0\u00a0units; P = 0.63) or on drinking days (mean 8.4 \u00b1 2.7 vs. 7.7 \u00b1 6.0\u00a0units; P = 0.76), in the number of days until relapse (P = 0.91) or in the proportion of subjects relapsing (37.5 vs. 41.2%; P = 0.84). Neither were there any statistically significant differences in any other outcomes, except a larger decrease in self-reported nervousness in the oxytocin group (P = 0.022).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The results were inconclusive as to whether intranasal oxytocin reduced the time to relapse, degree of craving or total amount of alcohol consumed after detoxification. However, the oxytocin group had a larger decrease in self-reported nervousness.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agaa133","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T12:09:03Z","timestamp":1605182943000},"page":"565-572","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy of Self-Administered Intranasal Oxytocin on Alcohol Use and Craving After Detoxification in Patients With Alcohol Dependence. A Double-Blind Placebo-Controlled Trial"],"prefix":"10.1093","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8367-9690","authenticated-orcid":false,"given":"Katrine","family":"Melby","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology \u2013 NTNU, Trondheim, Norway"},{"name":"Blue Cross Lade Addiction Treatment Centre, Trondheim, Norway"},{"name":"Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf W","family":"Gr\u00e5we","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology \u2013 NTNU, Trondheim, Norway"},{"name":"Department of Research and Development, Division of Psychiatry, St. Olav University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trond O","family":"Aamo","sequence":"additional","affiliation":[{"name":"Blue Cross Lade Addiction Treatment Centre, Trondheim, Norway"},{"name":"Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Skovlund","sequence":"additional","affiliation":[{"name":"Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology \u2013 NTNU, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav","family":"Spigset","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology \u2013 NTNU, Trondheim, Norway"},{"name":"Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, 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