{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:55:27Z","timestamp":1762005327005,"version":"3.37.3"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Minimum unit price (MUP) of 50 pence per unit of alcohol was introduced in Scotland on the 1 May 2018. We assessed alcohol-related liver disease (ArLD) discharges from Glasgow Royal Infirmary (GRI) before and after the introduction of MUP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Medical records of all patients discharged from Gastroenterology wards at GRI in the fourth quarter (Q4) of the years 2015\u20132019 were reviewed. All patients with ArLD were identified, and detailed hospitalization data were collected retrospectively. Active drinking, severity scores, presence of alcoholic hepatitis (AH) and 90-day mortality and readmission rates were assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were fewer ArLD discharges per quarter after MUP than before (mean 80.3 pre-MUP; mean 68 post-MUP), and the proportion of active drinkers was lower post-MUP (64.7 vs. 70.5%). There was a significant fall in the mean number of weekly discharges of individual patients who were actively drinking (4.0\u2009\u00b1\u20092.0 pre-MUP, 2.8\u2009\u00b1\u20091.5 post-MUP, P\u00a0=\u20090.01). There were no differences in the proportion of patients presenting with ascites, encephalopathy or AH; however, there was a reduction in presentations with acute upper gastrointestinal bleeding from 15.8% pre-MUP to 7.4% post-MUP (P\u00a0=\u20090.02; odds ratio 0.42). Severity of liver disease remained unchanged. The 90-day mortality and readmission rates were not significantly different.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Since the introduction of MUP there has been a reduction in the absolute numbers of patients discharged with ArLD and the number of individual patients involved at GRI. The pattern of clinical presentation was largely unaffected with overall ArLD severity, readmission rates and 90-day mortality similar pre- and post-MUP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agab051","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T19:11:25Z","timestamp":1627585885000},"page":"477-482","source":"Crossref","is-referenced-by-count":6,"title":["Changes in Hospital Discharges with Alcohol-Related Liver Disease in a Gastroenterology and General Medical Unit Following the Introduction of Minimum Unit Pricing of Alcohol: The GRI Q4 Study"],"prefix":"10.1093","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7088-4257","authenticated-orcid":false,"given":"Sardar","family":"Chaudhary","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Glasgow Royal Infirmary , Glasgow G4 0SF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"MacKey","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Glasgow Royal Infirmary , Glasgow G4 0SF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Glasgow Royal Infirmary , Glasgow G4 0SF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewan H","family":"Forrest","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Glasgow Royal Infirmary , Glasgow G4 0SF, UK"},{"name":"College of Medical , Veterinary and Life Sciences, , Glasgow G12 8QQ, UK"},{"name":"University of Glasgow , Veterinary and Life Sciences, , Glasgow G12 8QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"2022070920571701600_ref1","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1016\/S0140-6736(09)60744-3","article-title":"Effectiveness and cost-effectiveness of policies and programmes to reduce the harm caused by alcohol","volume":"373","author":"Anderson","year":"2009","journal-title":"Lancet"},{"volume-title":"An adaptation of the Sheffield Alcohol Policy Model version 3","year":"2016","author":"Angus","key":"2022070920571701600_ref2"},{"key":"2022070920571701600_ref3","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-013497","article-title":"Evidence for the effectiveness of minimum pricing of alcohol: a systematic review and assessment using the Bradford Hill criteria for causality","volume":"7","author":"Boniface","year":"2017","journal-title":"BMJ Open"},{"key":"2022070920571701600_ref4","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/hec.3105","article-title":"The Sheffield alcohol policy model - 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