{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:55:45Z","timestamp":1782842145932,"version":"3.54.5"},"reference-count":108,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Chronic alcohol consumption may result in liver injury and chronic liver disease, but other factors are likely to influence disease progression. Malnutrition, specifically micronutrient deficiency, is frequently associated with both alcohol use disorder and chronic liver disease. We hypothesize that micronutrient deficiencies may affect the progression of liver disease in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic integrative review of the medical literature; electronic search of MEDLINE 1950\u20132021; studies investigating role of any micronutrient in the acceleration of alcohol-related liver injury in humans or animals. Studies which specifically related to alcoholic hepatitis were excluded. Outcomes were extracted and recorded in tabulated form and discussed narratively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 46 studies investigating the role of micronutrient deficiencies in the pathogenesis of alcohol-related liver disease. Specific micronutrients which were identified included folic acid or related B vitamins (n\u2009=\u20099 studies), Vitamin D (n\u2009=\u20099 studies), magnesium (n\u2009=\u20098 studies), zinc (n\u2009=\u20098 studies) and selenium (n\u2009=\u200912 including one systematic review). Observational evidence suggests a potential role of magnesium deficiency in accelerating alcohol-related liver injury with weak or negative evidence for other micronutrients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Magnesium deficiency may increase the risk of alcohol-related liver injury and adverse liver outcomes. However, currently, there is insufficient evidence to support magnesium supplementation except for clinically relevant magnesium deficiency. Long-term prospective cohort studies assessing the impact of micronutrients on liver disease progression in patients with alcohol use disorder are lacking and may help determine whether there is a causal role for micronutrient deficiencies in alcohol-related liver injury.<\/jats:p><\/jats:sec>","DOI":"10.1093\/alcalc\/agab060","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T11:20:03Z","timestamp":1628076003000},"page":"275-282","source":"Crossref","is-referenced-by-count":18,"title":["The Role of Micronutrients in the Pathogenesis of Alcohol-Related Liver Disease"],"prefix":"10.1093","volume":"57","author":[{"given":"Ruairidh","family":"Nicoll","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Gerasimidis","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, New Lister Building, Glasgow Royal Infirmary, Glasgow G31 2ER, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewan","family":"Forrest","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"2022051008221320100_ref1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.21873\/invivo.11537","article-title":"Efficacy of ozone and selenium therapy for alcoholic liver injury: an experimental model","volume":"33","author":"Adali","year":"2019","journal-title":"In Vivo"},{"key":"2022051008221320100_ref2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/hep.510230121","article-title":"Role of cytochrome P4502E1-dependent 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