{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:13:53Z","timestamp":1791728033518,"version":"4.3.4"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Department of Bio-technology, Government of India"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To investigate abnormalities in bone mineral density, trabecular bone score and vertebral fractures in male patients with alcohol use disorder to understand the impact on bone health.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study subjects included 134 male patients. Controls were 134 age matched healthy males. Assessments were made of the bone mineral density (BMD), trabecular bone score (TBS) and vertebral morphometry (VFA) for vertebral fractures. Biochemical measurements included serum total T4, thyroid stimulating hormone (TSH), parathyroid hormone (PTH) and 25- Hydroxyvitamin D 25(OH) D.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean BMD at total forearm, proximal forearm (or distal 1\/3) and mid forearm was significantly higher in the alcohol use disorders (AUD) group than the controls (P\u2009&amp;lt;\u20090.01). Around 15% of patients with AUD had VFs compared with 9.0% of the healthy controls (P\u2009=\u20090.19). For each kg\/m2 gain in body mass index (BMI), lumbar spine and total hip BMD increased by 0.009 and 0.014\u00a0g\/cm2, respectively. Lumbar and hip BMD decreased by 0.002 and 0.003\u00a0g\/cm2 per year increase in duration of alcohol used. For every 5\u00a0years increase in age of the patients the odds of having VFs increased by 39% (odds ratio 1.393 [95% confidence interval\u2009=\u20091.031\u20131.881, P\u2009=\u20090.03]).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The findings of the current study suggest that persons with AUD in third and fourth decades of life, with BMI in normal range and with alcohol use disorder duration of around one decade might have no major alteration in BMD and TBS. Impact of alcohol use in this population was manifest by marginal increase in the prevalence of mild grade of vertebral fractures, mostly in the thoracic region.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agab084","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T12:09:14Z","timestamp":1638187754000},"page":"552-558","source":"Crossref","is-referenced-by-count":8,"title":["Bone Mineral Density, Bone Microarchitecture and Vertebral Fractures in Male Patients with Alcohol Use Disorders"],"prefix":"10.1093","volume":"57","author":[{"given":"Yatan Pal Singh","family":"Balhara","sequence":"first","affiliation":[{"name":"National Drug Dependence Treatment Center and Department of Psychiatry , , New Delhi 110029, India"},{"name":"All India Institute of Medical Sciences , , New Delhi 110029, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Narang","sequence":"additional","affiliation":[{"name":"National Drug Dependence Treatment Center and Department of Psychiatry , , New Delhi 110029, India"},{"name":"All India Institute of Medical Sciences , , New Delhi 110029, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soma","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of and Endocrinology and Metabolism , , New Delhi 110029, India"},{"name":"All India Institute of Medical Sciences , , New Delhi 110029, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devasenathipathy","family":"Kandasamy","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis , , New Delhi 110029, India"},{"name":"All India Institute of Medical Sciences , , New Delhi 110029, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naibedya","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , , Lucknow 226031, India"},{"name":"CSIR-Central Drug Research Institute , , Lucknow 226031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of and Endocrinology and Metabolism , , New Delhi 110029, India"},{"name":"All India Institute of Medical Sciences , , New Delhi 110029, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"2022091207505089000_ref1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11657-020-00841-1","article-title":"Physical and lifestyle factors associated with trabecular bone score values","volume":"15","author":"Anderson","year":"2020","journal-title":"Arch Osteoporos"},{"key":"2022091207505089000_ref2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"Anon","year":"2013","edition":"5th"},{"key":"2022091207505089000_ref3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.drugalcdep.2019.01.025","article-title":"The effect of alcohol on osteoporosis: a systematic review and meta-analysis","volume":"197","author":"Cheraghi","year":"2019","journal-title":"Drug Alcohol Depend"},{"key":"2022091207505089000_ref4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s40139-020-00209-7","article-title":"Impact of alcohol on bone health, homeostasis and fracture repair","volume":"8","author":"Eby","year":"2020","journal-title":"Curr Pathobiol Rep"},{"key":"2022091207505089000_ref5","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/acer.13000","article-title":"Alcohol: a simple nutrient with complex actions on bone in the adult skeleton","volume":"40","author":"Gaddini","year":"2016","journal-title":"Alcohol Clin Exp Res"},{"key":"2022091207505089000_ref6","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/oxfordjournals.aje.a010277","article-title":"Effect of alcohol intake on bone mineral density in elderly women: the EPIDOS study. 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