{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:04:01Z","timestamp":1790298241240,"version":"4.1.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y desarrollo","doi-asserted-by":"crossref","award":["210009"],"award-info":[{"award-number":["210009"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1200227"],"award-info":[{"award-number":["1200227"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["ZIA-AA000218"],"award-info":[{"award-number":["ZIA-AA000218"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["ZIA-DA000635"],"award-info":[{"award-number":["ZIA-DA000635"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Readmission is frequent among patients with cirrhosis and is a complex multifactorial process. To examine the association of alcohol use disorder (AUD) and risk of readmission in patients with alcohol-associated cirrhosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Results<\/jats:title>\n                  <jats:p>National Readmission Dataset (2016\u20132017) was used to extract a retrospective cohort of 53,348 patients with primary or secondary discharge diagnosis code of alcohol-associated cirrhosis with their first admission (26,674 patients with vs. propensity matched 26,674 without a primary or secondary discharge diagnosis code of AUD). Readmission within 30-day was lower (43.9 vs. 48%, P\u00a0&amp;lt;\u20090.001) among patients identified to have AUD at the time of discharge. In a conditional logistic regression model, a diagnosis of AUD was associated with 15% reduced odds of 30-day readmission, 0.85 (0.83\u20130.88). Furthermore, the reason for readmission among patients identified vs. not identified to have AUD was less likely to be liver disease complication. The findings remained similar in a matched cohort of patients where the AUD diagnosis at discharge was listed as one of the secondary diagnoses only.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Although, our study findings suggest that identification of AUD at the time of discharge among patients hospitalized for alcohol-associated cirrhosis reduces the risk of 30-day readmission, unavailable information on patient counseling, referral for mental health specialist and treatment received for AUD limit the causality assessment. Future studies are needed overcoming the inherent limitations of the database to establish the role of identification and treatment of AUD in reducing readmission and liver decompensation in patients with alcohol-associated cirrhosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agac015","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T19:59:54Z","timestamp":1651780794000},"page":"576-580","source":"Crossref","is-referenced-by-count":15,"title":["Identifying Alcohol Use Disorder in Patients With Cirrhosis Reduces 30-Days Readmission Rate"],"prefix":"10.1093","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-3998","authenticated-orcid":false,"given":"Ashwani K","family":"Singal","sequence":"first","affiliation":[{"name":"Department of Medicine , University of South Dakota, Vermillion, SD, USA"},{"name":"Avera Transplant Institute and McKennan University Hospital , Sioux Falls, SD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"DiMartini","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Transplant Surgery , and the Clinical and Translational Science Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Leggio","sequence":"additional","affiliation":[{"name":"Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section , Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Bethesda, MD, USA"},{"name":"Medication Development Program , National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA"},{"name":"Center for Alcohol and Addiction Studies , Department of Behavioral and Social Sciences, Brown University, Providence, RI, USA"},{"name":"Division of Addiction Medicine , Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"},{"name":"Department of Neuroscience , Georgetown University Medical Center, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8561-396X","authenticated-orcid":false,"given":"Juan P","family":"Arab","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterolog\u00eda , Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Fang","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Biostatistics , University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay H","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"2022091207511298100_ref1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s10620-019-05759-4","article-title":"Readmission rates and associated outcomes for alcoholic hepatitis: a nationwide cohort study","volume":"65","author":"Adejumo","year":"2020","journal-title":"Dig Dis Sci"},{"key":"2022091207511298100_ref2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41575-021-00527-0","article-title":"Management of alcohol use disorder in patients with cirrhosis in the setting of liver transplantation","volume":"19","author":"Arab","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2022091207511298100_ref3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.15288\/jsa.1991.52.37","article-title":"Patient factors predicting early alcohol-related readmissions for alcoholics: role of alcoholism severity and psychiatric co-morbidity","volume":"52","author":"Booth","year":"1991","journal-title":"J Stud Alcohol"},{"key":"2022091207511298100_ref4","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/j.cgh.2019.12.035","article-title":"Coordination of care is associated with survival and health care utilization in a population-based study of patients with cirrhosis","volume":"18","author":"Cohen-Mekelburg","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2022091207511298100_ref5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S2468-1253(19)30349-8","article-title":"The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"5","author":"Collaborators","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2022091207511298100_ref6","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S2468-1253(21)00191-6","article-title":"Barriers to the management of alcohol use disorder and alcohol-associated liver disease: strategies to implement integrated care model","volume":"7","author":"DiMartini","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2022091207511298100_ref7","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.21037\/atm-20-1762","article-title":"Incidence and predictors of 30-day hospital readmissions for liver cirrhosis: insights from the United States National Readmissions Database","volume":"9","author":"Garg","year":"2021","journal-title":"Ann Transl Med"},{"key":"2022091207511298100_ref8","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1001\/jamapsychiatry.2021.1271","article-title":"Use of medications for alcohol use disorder in the US: results from the 2019 National Survey on Drug Use and Health","volume":"78","author":"Han","year":"2021","journal-title":"JAMA Psychiat"},{"key":"2022091207511298100_ref9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cgh.2015.07.047","article-title":"Efficacy of psychosocial interventions in inducing and maintaining alcohol abstinence in patients with chronic liver disease: a systematic review","volume":"14","author":"Khan","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2022091207511298100_ref10","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1001\/jama.2018.12086","article-title":"Screening and behavioral counseling interventions to reduce unhealthy alcohol use in adolescents and adults: updated evidence report and systematic review for the US preventive services task force","volume":"320","author":"O'Connor","year":"2018","journal-title":"JAMA"},{"key":"2022091207511298100_ref11","first-page":"E80","article-title":"Lifestyle of patients with alcoholic liver disease and factors leading to hospital readmission: a prospective observational study","volume":"65","author":"Park","year":"2019","journal-title":"Kobe J Med Sci"},{"key":"2022091207511298100_ref12","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cgh.2019.04.048","article-title":"Alcohol rehabilitation within 30 days of hospital discharge is associated with reduced readmission, relapse, and death in patients with alcoholic hepatitis","volume":"18","author":"Peeraphatdit","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2022091207511298100_ref13","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1002\/hep.31042","article-title":"Impact of alcohol use disorder treatment on clinical outcomes among patients with cirrhosis","volume":"71","author":"Rogal","year":"2019","journal-title":"Hepatology"},{"key":"2022091207511298100_ref14","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/apt.16461","article-title":"Alcohol-associated liver disease in the US is associated with severe forms of disease among young, females and Hispanics","volume":"54","author":"Singal","year":"2021","journal-title":"Alimenta Pharmacol Ther"},{"key":"2022091207511298100_ref15","first-page":"165\u201376","article-title":"Diagnosis and Management of Alcohol-associated Liver Disease: a review","volume":"326","author":"Singal","year":"2021","journal-title":"JAMA"},{"key":"2022091207511298100_ref16","doi-asserted-by":"crossref","first-page":"88","DOI":"10.14309\/ajg.0000000000000411","article-title":"Increasing burden of acute-on-chronic liver failure among alcohol-associated liver disease in the young population in the United States","volume":"115","author":"Singal","year":"2020","journal-title":"Am J Gastroenterol"}],"container-title":["Alcohol and Alcoholism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/alcalc\/article-pdf\/57\/5\/576\/45784855\/agac015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/alcalc\/article-pdf\/57\/5\/576\/45784855\/agac015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T07:52:48Z","timestamp":1662969168000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/alcalc\/article\/57\/5\/576\/6583206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,11]]},"references-count":16,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,11]]},"published-print":{"date-parts":[[2022,9,10]]}},"URL":"https:\/\/doi.org\/10.1093\/alcalc\/agac015","relation":{},"ISSN":["0735-0414","1464-3502"],"issn-type":[{"value":"0735-0414","type":"print"},{"value":"1464-3502","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9]]},"published":{"date-parts":[[2022,5,11]]}}}