{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:06:51Z","timestamp":1793171211413,"version":"4.5.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Elysium Privatstiftung"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>While clinical consequences of thiamine deficiency in alcohol use disorder (AUD) are severe, evidence-based recommendations on dosage, type of administration and duration of thiamine substitution (TS), and its\u2019 target levels remain sparse. This study aimed to compare the effect of two best practice TS regimens on thiamine blood levels (i.e. thiamine pyrophosphate, TPP) and cognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 50 patients undergoing in-patient alcohol-withdrawal treatment, TPP levels were determined at baseline and end of weeks 1, 2 and 8 following administration of oral TS (3\u2009\u00d7\u2009100\u00a0mg\/day for 7\u00a0days followed by 1\u2009\u00d7\u2009100\u00a0mg\/day thereafter) either with or without preceding intravenous TS (3\u2009\u00d7\u2009100\u00a0mg\/day for 5\u00a0days). An extensive psychiatric assessment was conducted at baseline, including an evaluation of AUD severity and depressive symptoms. Additionally, cognitive function and depressive symptoms were repeatedly evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Relevant increases (mean increase by 100.2\u00a0nmol\/l [CI 76.5\u2013123.8], P\u2009&amp;lt;\u20090.001) in peripheral blood TPP levels were observed in all patients at the end of weeks 1 and 2. Furthermore, no relevant difference between the intravenous and the oral group was found (average difference between increases: 2.3\u00a0nmol\/l, P\u2009=\u20090.912). Importantly, an association between the \u2018extent of the response\u2019 to TS and the performance in a memory task was revealed in secondary analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TS was associated with improving cognitive function in patients with AUD, independently of the substitution regime. Thus, in clinical practice, oral TS might be a sufficient but obligatory medication to prevent cognitive decline in AUD in the absence of Wernicke\u2013Korsakoff Syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/alcalc\/agad017","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T18:39:16Z","timestamp":1676745556000},"page":"315-323","source":"Crossref","is-referenced-by-count":18,"title":["Can thiamine substitution restore cognitive function in alcohol use disorder?"],"prefix":"10.1093","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-0420","authenticated-orcid":false,"given":"Stephan","family":"Listabarth","sequence":"first","affiliation":[{"name":"Clinical Division of Social Psychiatry , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"},{"name":"Medical University of Vienna , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1195-630X","authenticated-orcid":false,"given":"Benjamin","family":"Vyssoki","sequence":"additional","affiliation":[{"name":"Clinical Division of Social Psychiatry , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"},{"name":"Medical University of Vienna , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1772-6695","authenticated-orcid":false,"given":"Rodrig","family":"Marculescu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Medical University of Vienna , 1090 Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8010-7665","authenticated-orcid":false,"given":"Andreas","family":"Gleiss","sequence":"additional","affiliation":[{"name":"Center for Medical Statistics , Informatics and Intelligent Systems, Institute of Clinical Biometrics, , 1090 Vienna , Austria"},{"name":"Medical University of Vienna , Informatics and Intelligent Systems, Institute of Clinical Biometrics, , 1090 Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3703-0399","authenticated-orcid":false,"given":"Magdalena","family":"Groemer","sequence":"additional","affiliation":[{"name":"Clinical Division of Social Psychiatry , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"},{"name":"Medical University of Vienna , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0899-8947","authenticated-orcid":false,"given":"Armin","family":"Trojer","sequence":"additional","affiliation":[{"name":"Clinical Division of Social Psychiatry , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"},{"name":"Medical University of Vienna , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Harrer","sequence":"additional","affiliation":[{"name":"Clinical Division of Social Psychiatry , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"},{"name":"Medical University of Vienna , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0855-5066","authenticated-orcid":false,"given":"Sabine","family":"Weber","sequence":"additional","affiliation":[{"name":"Clinical Division of Social Psychiatry , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"},{"name":"Medical University of Vienna , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5741-834X","authenticated-orcid":false,"given":"Daniel","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Clinical Division of Social Psychiatry , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"},{"name":"Medical University of Vienna , Department of Psychiatry and Psychotherapy, , 1090 Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,18]]},"reference":[{"key":"2023050921473603400_ref1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/00952990.2021.1978474","article-title":"Thiamine administration to all patients with alcohol use disorder: why not?","volume":"47","author":"Agabio","year":"2021","journal-title":"Am J Drug Alcohol 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