{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:28:14Z","timestamp":1771946894036,"version":"3.50.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French national PHRC"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Alcohol withdrawal syndrome (AWS) is a frequent and potentially life-threatening condition experienced in alcohol use disorder. Since hypomagnesemia is involved in AWS\u2019s severity, we conducted a multicenter double-blind randomized placebo-controlled trial to examine the efficacy of oral magnesium supplementation as an adjuvant therapy of AWS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Material and Methods<\/jats:title>\n                  <jats:p>Inpatients were recruited in six different centers if they had a baseline score higher than eight on the Revised Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar). The experimental treatment was magnesium lactate dehydrate, administrated three times per day providing a total of 426.6\u00a0mg per day and up to 15\u00a0days. The primary endpoint was the significant between-group difference of the CIWA-Ar total score change from baseline to 3\u00a0days later. The treatment group and baseline score were introduced as covariables in an analysis of covariance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 98 inpatients were included {71.4% of men; mean age of 49.1\u00a0years [standard deviation (SD): 10.3]}. In the intention-to-treat population, the mean reduction of the CIWA-Ar score in the experimental group between baseline and 3\u00a0days later was 10.1 (SD: 5.2), whereas it was 9.2 (SD: 3.9) in the control group. The absolute difference of the adjusted mean in the experimental group compared with the control group was \u22120.69 (SD: 0.72), which did not correspond to a significant between-group difference (P\u2009=\u20090.34). Per-protocol analysis and sensitivity analyses also supported this result. Supplementary analyses found no significant difference regarding benzodiazepine consumption, magnesium blood concentration, and satisfaction to care.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The present study does not support the rationale of systematic oral magnesium supplementation in patients with AWS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agad021","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T04:01:35Z","timestamp":1680580895000},"page":"329-335","source":"Crossref","is-referenced-by-count":5,"title":["Magnesium in the treatment of alcohol withdrawal syndrome: a multicenter randomized controlled trial"],"prefix":"10.1093","volume":"58","author":[{"given":"Guillaume","family":"Airagnes","sequence":"first","affiliation":[{"name":"AP-HP, Centre-Universit\u00e9 Paris Cit\u00e9 Department of Psychiatry and Addictology, , 20 rue Leblanc, 75015 Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9 Facult\u00e9 de Sant\u00e9, UFR de M\u00e9decine, , 15 Rue de l'\u00c9cole de M\u00e9decine, 75006 Paris, France"},{"name":"INSERM UMS011, Population-based Epidemiological Cohorts , H\u00f4pital Paul Brousse B\u00e2t. 15\/16, 16 avenue Paul Vaillant-Couturier, 94807 Villejuif Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9mi","family":"Valter","sequence":"additional","affiliation":[{"name":"AP-HP, Centre-Universit\u00e9 Paris Cit\u00e9 Department of Psychiatry and Addictology, , 20 rue Leblanc, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9raldine","family":"Ducoutumany","sequence":"additional","affiliation":[{"name":"AP-HP, Centre-Universit\u00e9 Paris Cit\u00e9 Department of Psychiatry and Addictology, , 20 rue Leblanc, 75015 Paris, 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Psychiatry and Neuroscience of Paris (IPNP) , INSERM U1266, 1 rue Cabanis, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Dubertret","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Facult\u00e9 de Sant\u00e9, UFR de M\u00e9decine, , 15 Rue de l'\u00c9cole de M\u00e9decine, 75006 Paris, France"},{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP) , INSERM U1266, 1 rue Cabanis, 75014 Paris, France"},{"name":"AP-HP, Centre-Universit\u00e9 Paris Cit\u00e9, University Hospital Louis Mourier Department of Psychiatry and Addictology, , 178 Rue des Renouillers, 92700 Colombes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joane","family":"Matta","sequence":"additional","affiliation":[{"name":"INSERM UMS011, Population-based Epidemiological Cohorts , H\u00f4pital Paul Brousse B\u00e2t. 15\/16, 16 avenue Paul Vaillant-Couturier, 94807 Villejuif Cedex, 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