{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:38:51Z","timestamp":1782902331327,"version":"3.54.5"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170608"],"award-info":[{"award-number":["82170608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shaanxi Science Foundation for Distinguished Young Scholars","award":["2021JC-36"],"award-info":[{"award-number":["2021JC-36"]}]},{"name":"Shaanxi Innovative Research Team for Science and Technology","award":["2022TD-53"],"award-info":[{"award-number":["2022TD-53"]}]},{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alcohol use is a major risk factor for the burden of mortality and morbidity. Alcoholic cirrhosis (AC) and alcoholic liver cancer (ALC) are most important and severe liver disease outcomes caused by alcohol use. The objectives of the current study were to investigate the global prevalence and burden of disease in disability-adjusted life years (DALYs) for AC and ALC, based on data from the Global Burden of Disease (GBD). Incidence, prevalence, death, and DALYs for GBDs in different locations, years, sex, and age groups were estimated using DisMod-MR 2.1 and a generic Cause of Death Ensemble Modeling approach. The correlations between the age-standardized incidence rate or age-standardized death rate and gender, sociodemographic index (SDI), and alcohol usage were conducted by Generalized Linear Models. Globally, the changes of age-standardized rates of indicators were not much significant over the 30-year period. However, the changes varied widely across regions. Central Asia and East Europe contributed the highest age-standardized incidence, prevalence, death, and DALYs and increased sharply by past 30\u00a0years. Generalized Linear Models (GLMs) showed male gender as a risk factor of AC, with the relative risk of incidence of 1.521 and relative risk of death of 1.503. Globally, there were improvements in overall health with regard to GBDs over the 30\u00a0years. However, the prevention of AC and ALC should be promoted in middle and middle-high SDI regions, especially Central Asia and East Europe, whereas more medical resources should be provided to improve treatment levels in low SDI region.<\/jats:p>","DOI":"10.1093\/alcalc\/agad046","type":"journal-article","created":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T05:36:55Z","timestamp":1689399415000},"page":"485-496","source":"Crossref","is-referenced-by-count":11,"title":["The global burden of alcoholic liver disease: a systematic analysis of the global burden of disease study 2019"],"prefix":"10.1093","volume":"58","author":[{"given":"Nan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering, The First Affiliated Hospital of Xi\u2019an Jiaotong University , 277 West Yanta Road, Xi\u2019an, Shaanxi Province , PR China"},{"name":"National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, The First Affiliated Hospital of Xi'an Jiaotong University , 277 West Yanta Road, Xi'an, Shaanxi Province , PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering, The First Affiliated Hospital of Xi\u2019an Jiaotong University , 277 West Yanta Road, Xi\u2019an, Shaanxi Province , PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ning","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering, The First Affiliated Hospital of Xi\u2019an Jiaotong University , 277 West Yanta Road, Xi\u2019an, Shaanxi Province , PR China"},{"name":"National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, The 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