{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:05:59Z","timestamp":1791137159120,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Psychological Sciences Undergraduate Research Fund"},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["P60 07611"],"award-info":[{"award-number":["P60 07611"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010249","name":"Indiana University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010249","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This study examined how adolescent social isolation affects adult binge-like alcohol drinking and stress\u2013axis function, via basal levels of circulating corticosterone (CORT), in male and female mice with a genetic predisposition toward high alcohol preference (HAP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Male and female HAP2 mice were randomly assigned to a group-housed or social isolation (ISO) group. Social isolation began at postnatal Days 40\u201342 and lasted for 21\u00a0days prior to assessment of binge-like alcohol drinking using a 4-day drinking-in-the-dark (DID) procedure. Blood samples to assess basal CORT were taken 6\u00a0days after social isolation ended and 24\u00a0h before DID started, and again 60\u00a0h after DID ended, during the light portion of the light cycle.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Adolescent social isolation increased adult binge-like alcohol drinking in male but not female mice. All groups showed significantly lower CORT after DID compared to before DID. Pearson bivariate correlation coefficients between the first 2\u00a0h of grams-per-kilogram alcohol intake on Day 4 and CORT levels indicated a significant positive correlation in ISO males only after DID and negative correlations in ISO females before and after DID.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings demonstrate that adolescent social isolation increased binge-like alcohol drinking in male but not female adult HAP2 mice. Stress\u2013axis adaptations in male HAP2 mice may be associated with the social-isolation-induced increase in binge-like alcohol drinking.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agae006","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T03:45:40Z","timestamp":1708141540000},"source":"Crossref","is-referenced-by-count":9,"title":["Adolescent social isolation increases binge-like alcohol drinking in male but not female high-alcohol-preferring mice"],"prefix":"10.1093","volume":"59","author":[{"given":"Eva C","family":"Cullins","sequence":"first","affiliation":[{"name":"Department of Psychological Sciences, Purdue University , 703 Third St., West Lafayette, IN 47907-2081 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A","family":"Chester","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences, Purdue University , 703 Third St., West Lafayette, IN 47907-2081 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