{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:12:02Z","timestamp":1780657922416,"version":"3.54.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Clinical Pharmacology"},{"name":"Clinic of Laboratory Medicine"},{"name":"St. Olav University Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To investigate the association between alcohol consumption registered daily with a digital smartphone-based diary and concentration of phosphatidylethanol (PEth) 16:0\/18:1 in a population without a known alcohol use disorder (AUD), and evaluate whether prospective registration of alcohol consumption is better than retrospective registration and if the association between alcohol intake and PEth was affected by sex or body mass index (BMI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 41 women and 21 men without AUD-diagnosis registered their alcohol consumption prospectively with a digital diary for 14\u00a0days, and retrospectively with the Timeline Followback method in the same time interval. PEth was measured before and after the registration period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The correlation between alcohol consumption and PEth varied from 0.65 to 0.87. It did not depend significantly on the reporting method, and was not influenced by sex or BMI. Based on the regression coefficient, a reduction of alcohol consumption by two alcohol units (26\u00a0g of pure ethanol) per day would lead to a reduction of the PEth concentration of about 0.1\u00a0\u03bcmol\/l, and vice versa.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>There was a good correlation between PEth concentration and alcohol consumption, both when alcohol consumption was reported prospectively and retrospectively. The preferred cut-off for PEth should be adjusted to the level of alcohol consumption considered harmful and a purposeful trade-off between sensitivity and specificity. In order to identify persons with a daily alcohol consumption of more than two or three\u00a0units of alcohol with a sensitivity of 80% or 90%, we suggest a cut-off of around 0.1\u00a0\u03bcmol\/l.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agae040","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T09:35:04Z","timestamp":1718616904000},"source":"Crossref","is-referenced-by-count":13,"title":["Relationship between alcohol intake based on daily smartphone-reported consumption and PEth concentrations in healthy volunteers"],"prefix":"10.1093","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-6297","authenticated-orcid":false,"given":"Trine","family":"Finanger","sequence":"first","affiliation":[{"name":"Clinic of Substance Use and Addiction Medicine, St. Olav University Hospital , 7030 Trondheim , Norway"},{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology , 7030 Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8367-9690","authenticated-orcid":false,"given":"Katrine","family":"Melby","sequence":"additional","affiliation":[{"name":"Clinic of Blue Cross Lade Addiction Treatment Centre , 7041 Trondheim , Norway"},{"name":"Department of Clinical Pharmacology, St. Olav University Hospital , Trondheim, 7030 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav","family":"Spigset","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology , 7030 Trondheim , Norway"},{"name":"Department of Clinical Pharmacology, St. Olav University Hospital , Trondheim, 7030 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine N","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, St. Olav University Hospital , Trondheim, 7030 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stian","family":"Lydersen","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Norwegian University of Science and Technology , Trondheim, 7030 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnhild Bergene","family":"Skr\u00e5stad","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology , 7030 Trondheim , Norway"},{"name":"Department of Clinical Pharmacology, St. Olav University Hospital , Trondheim, 7030 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"2024062612561086100_ref1","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1111\/acer.13471","article-title":"Cut-point levels of phosphatidylethanol to identify alcohol misuse in a mixed cohort including 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