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Unbalance in this microbial ecosystem has been shown to be associated with psychiatric disorders, and altered gut microbiome composition related to bacteria, viruses, and fungi has been well established in patients with alcohol use disorder. This review describes the gut microbiome\u2013brain communication pathways, including the ones related to the vagus nerve, the inflammatory cytokines, and the gut-derived metabolites. Finally, the potential benefits of microbiota-based therapies for the management of alcohol use disorder, such as probiotics, prebiotics, and fecal microbiota transplantation, are also discussed.<\/jats:p>","DOI":"10.1093\/alcalc\/agae050","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T21:33:36Z","timestamp":1721856816000},"source":"Crossref","is-referenced-by-count":4,"title":["2023 ESBRA Nordmann Award Lecture: Involvement of the gut microbiome-brain axis in alcohol use disorder"],"prefix":"10.1093","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-5220","authenticated-orcid":false,"given":"Sophie","family":"Leclercq","sequence":"first","affiliation":[{"name":"Laboratory of Nutritional Psychiatry, Institute of Neuroscience, Universit\u00e9 Catholique de Louvain , 1200 Brussels , 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