{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:11:21Z","timestamp":1792793481443,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG006786"],"award-info":[{"award-number":["U01 AG006786"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG072898"],"award-info":[{"award-number":["R01 AG072898"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Samuel C. Johnson Genomics of Addiction Program at Mayo Clinic","id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ulm Foundation"},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01 AA029258"],"award-info":[{"award-number":["R01 AA029258"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R21 AA028968"],"award-info":[{"award-number":["R21 AA028968"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Excessive alcohol use is associated with an increased risk of cognitive impairment. Since increased amyloid plaque burden exacerbates cognitive decline, we sought to assess the potential impact of alcohol use disorder (AUD) on cognition, memory, and amyloid burden corresponding with age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted the retrospective analysis with 6036 subjects, including 269 AUD+ subjects. A four-item CAGE (C\u2014Cutting Down, A\u2014Annoyance by Criticism, G\u2014Guilty Feeling, E\u2014Eye-openers) alcohol questionnaire was given during the recruitment to determine AUD in each participant. We assessed cognitive function, focusing on memory using neuropsychological testing. For 1038 participants, including 57 AUD+ subjects, we measured amyloid burden using the 11C Pittsburgh Compound B tracer-based positron emission tomography imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AUD+ was significantly associated with lower scores of cognition and memory function relative to AUD\u2212 individuals. No significant association was found with AUD and elevated brain amyloid under the age of 65. However, further analysis showed that those aged \u226565 showed greater odds for abnormal amyloid in AUD+ compared to AUD\u2212 participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results underscore AUD as a risk factor for cognitive decline and diminished memory, particularly in aging populations. The role of AUD in brain amyloid accumulation requires further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/alcalc\/agae080","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T07:28:37Z","timestamp":1731396517000},"source":"Crossref","is-referenced-by-count":10,"title":["Impact of alcohol use disorder on cognition in correlation with aging: a community-based retrospective cohort study"],"prefix":"10.1093","volume":"60","author":[{"given":"Hesham","family":"Essa","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science , 200 First Street SW, Rochester, MN 55905 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam M","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science 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Medicine and Science ,","place":["200 First Street SW, Rochester, MN 55905, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic College of Medicine and Science ,","place":["200 First Street SW, Rochester, MN 55905, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S","family":"Knopman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic College of Medicine and Science ,","place":["200 First Street SW, Rochester, MN 55905, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S","family":"Lundt","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic College of Medicine and Science ,","place":["200 First Street SW, Rochester, MN 55905, United 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