{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T15:59:45Z","timestamp":1776959985542,"version":"3.51.4"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":45,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centers of Disease Control and Prevention, National Center of Immunization and Respiratory Diseases"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Alcohol consumption along with negative sequelae from excess alcohol intake increased during the COVID-19 pandemic. We evaluated the association between binge alcohol use and long-term functional outcomes among COVID-19-positive individuals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using a prospective, longitudinal, multisite cohort study design, we evaluated the association between binge alcohol use and mental and physical functional outcomes using Patient-Reported Outcomes Measurement Information System (PROMIS)-29 scores three and six months postinfection. Eligible patients were those who presented with COVID-19-like symptoms, tested positive for COVID-19, and completed a three-month survey. Binge drinking was identified at the time of infection using the Tobacco, Alcohol, Prescription medication and other Substance use screener. Generalized estimating equation models, adjusted for demographic characteristics, social determinants of health, substance use, comorbidities, and COVID-19 vaccine status, were used to assess the association between binge alcohol use and mental and physical functional outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 3529 individuals, 23.7% screened positive for binge drinking. At three\u00a0months, prior self-reported binge drinking was associated with differences in physical function [estimate:\u20091.08; 95% confidence interval (CI) 0.44, 1.71], pain interference (estimate: \u22120.86; 95% CI \u22121.57, \u22120.15), and physical health (estimate:\u20091.09; 95% CI 0.43, 1.75). At six\u00a0months, no associations were found between binge drinking and outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Binge alcohol use before COVID-19 infection was associated with statistically significant but clinically irrelevant improvements in function at three\u00a0months, which were not sustained at six\u00a0months. Postinfectious and postpandemic stressors may have played a larger impact on functional outcomes than binge alcohol use. A higher frequency of binge drinking and its association with functional outcomes, particularly among individuals with COVID-19 warrants further study.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agae086","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T17:23:27Z","timestamp":1735838607000},"source":"Crossref","is-referenced-by-count":1,"title":["Association of binge alcohol use with functional outcomes among individuals with COVID-19 infection"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2038-0250","authenticated-orcid":false,"given":"Sebastian T","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Family Medicine , , 4225 Roosevelt Way NE, Suite 308, Seattle, WA, 98105 ,","place":["United States"]},{"name":"University of Washington , , 4225 Roosevelt Way NE, Suite 308, Seattle, WA, 98105 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gottlieb","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Rush University Medical Center , Chicago, IL, 600 S. Paulina St, Chicago, IL, 60612 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imtiaz","family":"Ebna Mannan","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research and Evaluation (CORE) , Section of Cardiovascular Medicine, , 195 Church Street, 5th Floor, New Haven, CT, 06510 ,","place":["United States"]},{"name":"Yale School of Medicine , Section of Cardiovascular Medicine, , 195 Church Street, 5th Floor, New Haven, CT, 06510 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Family Medicine , , 4225 Roosevelt Way NE, Suite 308, Seattle, WA, 98105 ,","place":["United States"]},{"name":"University of Washington , , 4225 Roosevelt Way NE, Suite 308, Seattle, WA, 98105 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Family Medicine , , 4225 Roosevelt Way NE, Suite 308, Seattle, WA, 98105 ,","place":["United States"]},{"name":"University of Washington , , 4225 Roosevelt Way NE, Suite 308, Seattle, WA, 98105 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Santangelo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Rush University Medical Center , Chicago, IL, 600 S. Paulina St, Chicago, IL, 60612 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristyn","family":"Gatling","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Rush University Medical Center , Chicago, IL, 600 S. Paulina St, Chicago, IL, 60612 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efrat","family":"Kean","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University , 1020 Walnut Street, Philadelphia, PA, 19107 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Watts","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University , 1020 Walnut Street, Philadelphia, PA, 19107 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Wang","sequence":"additional","affiliation":[{"name":"University of California, San Francisco , 505 Parnassus Ave, San Francisco, CA, 94143 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Montoy","sequence":"additional","affiliation":[{"name":"University of California, San Francisco , 505 Parnassus Ave, San Francisco, CA, 94143 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahamed","family":"Idris","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd, Dallas, TX, 75390 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"MacDonald","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd, Dallas, TX, 75390 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Huebinger","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston, McGovern Medical School , 6431 Fannin St, Houston, TX, 77030 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Hill","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston, McGovern Medical School , 6431 Fannin St, Houston, TX, 77030 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelli N","family":"O\u2019Laughlin","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine , , 1705 NE Pacific Street, Seattle, WA, 98195 ,","place":["United States"]},{"name":"University of Washington , , 1705 NE Pacific Street, Seattle, WA, 98195 ,","place":["United States"]},{"name":"Department of Global Health , , 3980 15th Ave NE, Seattle, WA, 98105 ,","place":["United States"]},{"name":"University of Washington , , 3980 15th Ave NE, Seattle, WA, 98105 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole L","family":"Gentile","sequence":"additional","affiliation":[{"name":"Department of Family Medicine , , 4225 Roosevelt Way NE, Suite 308, Seattle, WA, 98105 ,","place":["United States"]},{"name":"University of Washington , , 4225 Roosevelt Way NE, Suite 308, Seattle, WA, 98105 ,","place":["United States"]},{"name":"Department of Laboratory Medicine and Pathology , , 9750 3rd Ave NE, Suite 400, Seattle, WA, 98115 ,","place":["United States"]},{"name":"University of Washington , , 9750 3rd Ave NE, Suite 400, Seattle, WA, 98115 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn","family":"Dorney","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine , , 333 Cedar Street, New Haven, CT, 06510 ,","place":["United States"]},{"name":"Yale School of Medicine , , 333 Cedar Street, New Haven, CT, 06510 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Malicki","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine , , 464 Congress Ave, New Haven, CT, 06519 ,","place":["United States"]},{"name":"Yale School of Medicine , , 464 Congress Ave, New Haven, CT, 06519 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joann G","family":"Elmore","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine and Health Services Research , , 1100 Glendon Avenue, Suite 850, Los Angeles, CA, 90024 ,","place":["United States"]},{"name":"David Geffen School of Medicine at the University of California, Los Angeles , , 1100 Glendon Avenue, Suite 850, Los Angeles, CA, 90024 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Diaz Roldan","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine and Health Services Research , , 1100 Glendon Avenue, Suite 850, Los Angeles, CA, 90024 ,","place":["United States"]},{"name":"David Geffen School of Medicine at the University of California, Los Angeles , , 1100 Glendon Avenue, Suite 850, Los Angeles, CA, 90024 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics , , 1705 NE Pacific St, Seattle, WA, 98195 ,","place":["United States"]},{"name":"University of Washington , , 1705 NE Pacific St, Seattle, WA, 98195 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenqiu","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research and Evaluation (CORE) , Section of Cardiovascular Medicine, , 195 Church Street, 5th Floor, New Haven, CT, 06510 ,","place":["United States"]},{"name":"Yale School of Medicine , Section of Cardiovascular Medicine, , 195 Church Street, 5th Floor, New Haven, CT, 06510 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases , Department of Internal Medicine, , 600 S Paulina St, Chicago, IL, 60612 ,","place":["United States"]},{"name":"Rush University Medical Center , Department of Internal Medicine, , 600 S Paulina St, Chicago, IL, 60612 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari A","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Family Medicine , , 4225 Roosevelt Way NE, Suite 308, Seattle, WA, 98105 ,","place":["United States"]},{"name":"University of Washington , , 4225 Roosevelt Way NE, Suite 308, Seattle, WA, 98105 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"2025030418133644300_ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/adb0000796","article-title":"Changes in alcohol use during COVID-19 and associations with contextual and individual difference variables: A systematic review and meta-analysis","volume":"36","author":"Acuff","year":"2022","journal-title":"Psychol Addict Behav"},{"key":"2025030418133644300_ref2","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1176\/appi.ps.202000534","article-title":"The impact of substance use disorder on COVID-19 outcomes","volume":"72","author":"Baillargeon","year":"2021","journal-title":"Psychiatr Serv"},{"key":"2025030418133644300_ref3","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1080\/10550887.2022.2058852","article-title":"A narrative review of the use of alcohol during the Covid-19 pandemic; effects and implications","volume":"41","author":"Bantounou","year":"2023","journal-title":"J Addict Dis"},{"key":"2025030418133644300_ref4","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/ADM.0000000000000767","article-title":"Alcohol consumption in response to the COVID-19 pandemic in the USA","volume":"15","author":"Barbosa","year":"2021","journal-title":"J Addict Med"},{"key":"2025030418133644300_ref5","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.pnpbp.2015.09.001","article-title":"Opposing effects of alcohol on the immune system","volume":"65","author":"Barr","year":"2016","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"2025030418133644300_ref6","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1056\/NEJMp2202740","article-title":"Research to move policy \u2014 Using evidence to advance health equity for substance use disorders","volume":"386","author":"Blanco","year":"2022","journal-title":"N Engl J Med"},{"key":"2025030418133644300_ref7","doi-asserted-by":"publisher","first-page":"26854","DOI":"10.17226\/26854","volume-title":"Achieving Whole Health: A New Approach for Veterans and the Nation","author":"Krist","year":"2023"},{"key":"2025030418133644300_ref8","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/j.dld.2022.07.007","article-title":"Covid-19 and alcohol associated liver disease","volume":"54","author":"Deutsch-Link","year":"2022","journal-title":"Dig Liver Dis"},{"key":"2025030418133644300_ref9","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/liv.15172","article-title":"Alcohol-related hepatitis admissions increased 50% in the first months of the COVID-19 pandemic in the USA","volume":"42","author":"Gonzalez","year":"2022","journal-title":"Liver Int"},{"key":"2025030418133644300_ref10","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1007\/s11606-017-4079-x","article-title":"Validation of the TAPS-1: A four-item screening tool to identify unhealthy substance use in primary care","volume":"32","author":"Gryczynski","year":"2017","journal-title":"J Gen Intern Med"},{"key":"2025030418133644300_ref11","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1007\/s11136-018-1842-3","article-title":"PROMIS\u00ae-29 v2.0 profile physical and mental health summary scores","volume":"27","author":"Hays","year":"2018","journal-title":"Qual Life Res"},{"key":"2025030418133644300_ref12"},{"key":"2025030418133644300_ref13"},{"key":"2025030418133644300_ref14","doi-asserted-by":"publisher","first-page":"e0264260","DOI":"10.1371\/journal.pone.0264260","article-title":"Study protocol for the innovative support for patients with SARS-COV-2 infections registry (INSPIRE): A longitudinal study of the medium and long-term sequelae of SARS-CoV-2 infection","volume":"17","author":"O\u2019Laughlin","year":"2022","journal-title":"PLoS One"},{"key":"2025030418133644300_ref15","doi-asserted-by":"publisher","first-page":"106532","DOI":"10.1016\/j.addbeh.2020.106532","article-title":"Drinking to cope with the pandemic: The unique associations of COVID-19-related perceived threat and psychological distress to drinking behaviors in American men and women","volume":"110","author":"Rodriguez","year":"2020","journal-title":"Addict Behav"},{"key":"2025030418133644300_ref16","doi-asserted-by":"publisher","first-page":"e210422","DOI":"10.1001\/jamanetworkopen.2021.0422","article-title":"Alcohol withdrawal rates in hospitalized patients during the COVID-19 pandemic","volume":"4","author":"Sharma","year":"2021","journal-title":"JAMA Netw Open"},{"key":"2025030418133644300_ref17","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1001\/jama.2022.4308","article-title":"Alcohol-related deaths during the COVID-19 pandemic","volume":"327","author":"White","year":"2022","journal-title":"JAMA"}],"container-title":["Alcohol and Alcoholism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/alcalc\/article-pdf\/60\/1\/agae086\/61318957\/agae086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/alcalc\/article-pdf\/60\/1\/agae086\/61318957\/agae086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T20:16:57Z","timestamp":1741119417000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/alcalc\/article\/doi\/10.1093\/alcalc\/agae086\/7939978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,11,18]]}},"URL":"https:\/\/doi.org\/10.1093\/alcalc\/agae086","relation":{},"ISSN":["0735-0414","1464-3502"],"issn-type":[{"value":"0735-0414","type":"print"},{"value":"1464-3502","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,1]]},"published":{"date-parts":[[2024,11,18]]},"article-number":"agae086"}}