{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:33:13Z","timestamp":1772137993150,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"NSF-CAREER","award":["2235858"],"award-info":[{"award-number":["2235858"]}]},{"name":"NIH-NIDA","award":["R01DA058653"],"award-info":[{"award-number":["R01DA058653"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R25GM132959-05"],"award-info":[{"award-number":["1R25GM132959-05"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We sought to explore how acute alcohol exposure alters decision-making in rats performing an approach-avoid decision-making task. Increasing concentrations of alcohol were mixed with decreasing concentrations of sucrose to mimic mixed\/sweetened alcoholic beverages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats were trained on an apparatus in which different concentrations of sucrose were available in four different corners of the arena. During daily sessions, a tone signaled each trial start, followed by illumination (15\u00a0lux, blue LEDs) of a single corner port, indicating the potential availability of sucrose at that location. The rat (one rat per arena, both females and males) then chose to approach the lit corner to have the solution dispensed or avoid it, with no solution being dispensed. We examined how the decisions to pursue sucrose rewards shifted with the addition and subsequent removal of ethanol from the sucrose ports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Males were greatly affected by the introduction of alcohol into the task environment, shifting their approach preference to solutions containing higher alcohol concentrations rather than maintaining the prior preference for high-sucrose-concentration solutions. In contrast, females\u2019 choice patterns and task performance remained largely unchanged. We also explore a method for identifying changes in decision-making tendencies during and after alcohol consumption within individual subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This research explores the introduction of alcohol in varying concentrations with sucrose solutions during an approach-avoid task, with male decision-making and behavioral patterns significantly impacted. We also explore a novel approach for identifying individual adaptations of decision-making behavior when alcohol becomes available, which could be expanded upon in future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/alcalc\/agaf017","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T13:57:11Z","timestamp":1743429431000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of acute alcohol consumption in a novel rodent model of decision-making"],"prefix":"10.1093","volume":"60","author":[{"given":"Atanu","family":"Giri","sequence":"first","affiliation":[{"name":"Computational Science Program, University of Texas at El Paso , 500 W University Ave, El Paso, TX 79968 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cory N","family":"Heaton","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Texas at El Paso , 500 W University Ave, 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